Protein Alignment Nlg2 and Ces1f

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001096829.2
• Gene: Ces1f / 100125372
• RGDID: 1642419
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 722
• Identity: 172/722 - (23%)
• Similarity: 274/722 - (37%)
• Gaps: 220/722 - (30%)

  Fly   162 LVLLLLTSLWPDCCECLHGGS-------NTVK----TKYGLLRGIVVRSSPLVEAFLGIPYASPP 215
            |..|.|.||    ..|:..|:       :|.|    .||..|.|:    :..|..|||:|:|.||
  Rat     3 LSFLFLVSL----ATCVVYGNPSSPPVVDTTKGKVLGKYVSLEGV----TQSVAVFLGVPFAKPP 59

  Fly   216 VGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQ-- 278
            :|||||.||.....|..|::...:.|:|.|:                  .|:.:|:..||.|:
  Rat    60 LGSLRFAPPQPAEPWSFVKNTTTYPPMCSQD------------------AAKGQRMNDLLTNRKE 106

  Fly   279 ------SEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAA 337
                  ||||||||||.|.:..:..|            |..:|:|||........:.|||..|:|
  Rat   107 KIHLEFSEDCLYLNIYTPADFTKNSR------------LPVMVWIHGGGMTLGGASTYDGRVLSA 159

  Fly   338 HGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTG 402
            :.||:||.|.:||||:||..| |.|.::||:|.:|.||.|||:::|:..|||||.|:|:.|...|
  Rat   160 YENVVVVAIQYRLGIWGFFST-GDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAG 223

  Fly   403 AVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRT 467
            ....::||:||:..:|..|.:..||....|..:.|:.....:::|:..||. ......:..|||.
  Rat   224 GFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCE-TTTSAIIVHCLRQ 287

  Fly   468 KSVAELL-------AVKVDHPR-------FLVGFAPFVDGTVISPGANPL----GSTTLP----- 509
            |:..|||       .:|:...|       ||   :..||..|:......:    ...|:|
  Rat   288 KTEEELLEIMKKMNLIKLSSQRDNKESYHFL---STVVDNVVLPKDPKEILAEKNFNTVPYIVGI 349

  Fly   510 ----LGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFH 570
                .|..:.:..|...|:. :.|....:|.:|.:..|      :|..|
  Rat   350 NKQECGWLLPTMMGFVPADV-ELDKKMAITLLEKFASL------YGIPE---------------- 391

  Fly   571 YHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKH 635
                :|..|...:|   .|...:.:..||..|.|:.|...:.|.:.:...|...|...|...:::
  Rat   392 ----DIIPVAIEKY---RKGSDDSIKIRDGILAFIGDVSFSIPSVMVSRDHRDAGAPTYMYEYQY 449

  Fly   636 KTIEEEY-----PQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPN 695
                  |     |||...|.|:.......:..:|:.....:.:|.::.::::::.:|||:.||||
  Rat   450 ------YPSFSSPQRPKHVVGDHADDLYSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPN 508

  Fly   696 QSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRS 760
                                                                             
  Rat   509 ----------------------------------------------------------------- 508

  Fly   761 NDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLI--- 822
                                |..||.|..||...: |:::|.........:..:::.|..|:
  Rat   509 --------------------GRGLPHWPQYDQKEE-YLQIGATTQQSQRLKAEEVAFWTQLLAKR 552

  Fly   823 -PQLHRH 828
             ||.|.:
  Rat   553 QPQPHHN 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	152/597 (25%)
Ces1f	NP_001096829.2	COesterase	22..545	CDD:395084	160/683 (23%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	558..561		0/2 (0%)