Protein Alignment Nlg2 and Nlgn4l

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001423254.1
• Gene: Nlgn4l / 100113365
• MGIID: 3775191
• Length: 945
• Species: Mus musculus
• Alignment Length: 1004
• Identity: 267/1004 - (26%)
• Similarity: 399/1004 - (39%)
• Gaps: 309/1004 - (30%)

  Fly   185 VKTKYGLLRGIVVRSS-------PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242
            |.|.||.|||  ||::       |:.: |||:|||:||.|..||.||..||:|..||.|.||:||
Mouse    31 VATNYGKLRG--VRAALPGDVLGPVTQ-FLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPV 92

  Fly   243 CPQNIPIPPNGPEALL--EVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTG 305
            |||::     ...|||  .:|....|.|..:...:::|||||||||:||| .....::..||.||
Mouse    93 CPQHL-----DERALLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVP-GGANGKKMADDVTG 151

  Fly   306 ----------EP--------KTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGI 352
                      :|        ..:...:|:|||.||...:.|..|||.||::|:|||||:|:|||:
Mouse   152 NDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLGV 216

  Fly   353 FGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASD 417
            .|||.| |.::|:||:||:|.:..|.|::||..||||||..:|:.|.|.||...::|.:|..:..
Mouse   217 LGFLST-GDQAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVSLLTLSHYSEG 280

  Fly   418 LIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGC------------HGDMLYD--DLAPCLRTK 468
            |.|:.::.||:|||.||:...|....|.:.|:.||            .|   :|  .|..|||.|
Mouse   281 LFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPG---WDSASLVSCLRGK 342

  Fly   469 SVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFC 533
            :..||...:|....:.|.|.|.|||.||            |....|:...| |:.|:   |::..
Mouse   343 AAGELARARVTPATYHVAFGPTVDGDVI------------PDDPQILMEQG-EFLNY---DIMLG 391

  Fly   534 LTSVES--YLD-------------------------------------LSAQDLE---------- 549
            :...|.  ::|                                     :||.:.:
Mouse   392 VNQGEGARFVDGLGGGHDGGYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDL 456

  Fly   550 FGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFL-SDGHTASP 613
            :|..|.|.|.:..|                :|..||||  |.|:...:|..||..| :|....:|
Mouse   457 YGRPEGRGDALRET----------------VKFMYTDW--ADRDSPEARRKTLVALFTDHQWVAP 503

  Fly   614 LIKLGYMHSLRGGRAYFLHFKHKTI----------------------EEEYPQRSGSVRGEDVPF 656
            .:....:|:..|...||..|.|:..                      ||..|..:.:..|::||:
Mouse   504 AVATADLHARYGSPTYFYAFYHRCHGGGGGGGGVDGVAGGVAGGVGGEEARPAWADAAHGDEVPY 568

  Fly   657 WLGLPMS---PLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKS---VLPNPNEVLETALH 715
            ..|:||:   .:|..|::..:..:..:::.|.:||||||:|||..|:.   |...||...|.|
Mouse   569 VFGVPMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPNQPVAQDTRFVHTRPNRFEEVA-- 631

  Fly   716 QQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYD 780
                                                                             
Mouse   632 ----------------------------------------------------------------- 631

  Fly   781 GDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDM 845
                  |..||...|||:.:|.:..::.|||..|::.||.|:|.||
Mouse   632 ------WAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLH------------------- 671

  Fly   846 NNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPL-GTGTP---TTT 906
                   |:.        |:....:....:|......|.::|.........|. .|..|   |::
Mouse   672 -------GLA--------ADPGAYLSAAATRAAPSGDPDRDPGGGGGGRRRPRPATRRPAVMTSS 721

  Fly   907 ECGIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALI 971
            .......|:.|..:...|...:....|.:||::|                         |:|.|.
Mouse   722 SMASGSGMTSSSGSGMTSSSGSSASAVLIETRRD-------------------------YSTELS 761

  Fly   972 ATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSIL-----KLNALMGG--G 1029
            .|:|||..||.||||.||.:|::::||..:...:........:..|:..     :.:....|  |
Mouse   762 VTIAVGASLLFLNVLAFAALYYKKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAGRRG 826

  Fly  1030 GACGSGPGDIADAYTLSGSVVDSKGGVGV 1058
            |.||:....:|...:..|...|..|||||
Mouse   827 GECGAVVTAMAAEASAGGLGHDGVGGVGV 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	202/662 (31%)
Nlgn4l	NP_001423254.1	COesterase	30..663	CDD:395084	213/751 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..167		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..742		10/56 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..828		5/40 (13%)