DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and nlgn2b

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001159808.1	Gene:	nlgn2b / 100002407	ZFINID:	ZDB-GENE-090918-3	Length:	860	Species:	Danio rerio

Alignment Length:	1060	Identity:	298/1060 - (28%)
Similarity:	444/1060 - (41%)	Gaps:	268/1060 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EACALLVLLLLTSLWPDCCECLHGGSNTVK-----TKYGLLRGI--VVRSSPL--VEAFLGIPYA 212
            :.|  ||.||..:|......|......|.|     |.||.|||:  .:.:..|  ||.:||:|||
Zfish    23 DTC--LVWLLGLALRLALSSCQRADLTTAKHPMVTTGYGKLRGVRKELNNEILGPVEQYLGVPYA 85

  Fly   213 SPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNG--PEALLEVPRARLAQLRRLLPLL 275
            :||||..||.||..|.:|:.:|:|.:|:|||||||    :|  ||.:|  |......|......:
Zfish    86 TPPVGERRFQPPEAPGSWQEIRNATQFAPVCPQNI----HGVLPEIML--PVWFTDNLDAAAAYV 144

  Fly   276 KNQSEDCLYLNIYVPYETRRQRRNTDDTT-GEP-------KTKLSTVVFIHGESYDWNSGNPYDG 332
            :||||||||||:|||.|.....:..|::: ..|       :.|...::||||.|:...:||.:|.
Zfish   145 QNQSEDCLYLNVYVPTEDGPLTKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSFMEGTGNMFDA 209

  Fly   333 SELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLL 397
            |.|||:|||||||:|:|||:.||| :.|.:||:||:||:|.:..|.||.||:..|||||:.||:.
Zfish   210 SVLAAYGNVIVVTMNYRLGVLGFL-SSGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIF 273

  Fly   398 GYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGC-HGDMLYDDL 461
            |.|.||...|:|::|..:..|.||.:..||||:|.|::...||...:.:|::.|| :.|..  ||
Zfish   274 GSGAGASCVNLLILSHHSEGLFQRAIAQSGSAISSWSVNYRPLMYTKILAKKVGCSYSDTA--DL 336

  Fly   462 APCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFP 526
            ..|||.||..||:...|...|:.:.|.|.|||.|:            |....|:...| |:.|:
Zfish   337 VDCLRRKSYRELVDQDVQPARYHIAFGPVVDGDVV------------PDDPEILMQQG-EFLNY- 387

  Fly   527 KRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYH-----LNEIFAVLKNEYTD 586
              |::..:...|....:...:.|.|.:....|..:..||.|.:.|.     |.|   .:|..|||
Zfish   388 --DILLGVNQGEGLKFVDDNEGEEGISAASFDYTISNFVDNLYGYPEGKDILRE---TIKFMYTD 447

  Fly   587 WEKAIRNPLSSRDATLQFL-SDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVR 650
            |  |.|:....|..||..| :|....:|.:....:|:......||..|.|....|..|:.:.:..
Zfish   448 W--ADRDNGDMRRKTLLALFTDHQWVAPAVATAKLHAEFQSPVYFYTFHHHCQTEARPEWADAAH 510

  Fly   651 GEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLET 712
            |:::|:..|:||   :.|||.|::..:..:..:::.|.:||||||:||       :|.|.:.  .
Zfish   511 GDEIPYVFGVPMVGATELFPCNFSKNDIMLSAVVMTYWTNFAKTGDPN-------IPVPQDT--K 566

  Fly   713 ALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVG 777
            .:|         |.||..|.:
Zfish   567 FIH---------TKPNRFEEV-------------------------------------------- 578

  Fly   778 SYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQ 842
                    .|..:...::.|:.:|.|..|:.:||.:|::.||.|:|.||   .|:|:
Zfish   579 --------IWTKFSSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHLH---TIHDE-------- 624

  Fly   843 DDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNAT-QALNPLGTGTPTTT 906
                                         :....|..||.....|....| |:.....|..||.:
Zfish   625 -----------------------------IPTYTTQLPPGAPHRPGWKGTAQSPGTRSTRHPTVS 660

  Fly   907 ECGIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALI 971
            ....|..:..||....:.|..:.|                                 :.|:|.|.
Zfish   661 TYPPDPDLEGSEHPPERFPFPSNT---------------------------------RDYSTELS 692

  Fly   972 ATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSILKLNALMGGGGACGSGP 1036
            .|||||..||.||||.||.:|::|:||      .|.||.    ::..:......:.|.|..|..|
Zfish   693 VTVAVGASLLFLNVLAFAALYYKRDKR------HELLQR----RHRRLSPQRGAVPGVGIVGGPP 747

  Fly  1037 -GDIADAYTLSGSVVDSKGGVGVVFGEYSCYDEKTKQLKEEKLLVELPPSSSTGQTSLMIDNWGA 1100
             .|:|    ||                           :||:|:     |....|..:.:|:...
Zfish   748 HNDLA----LS---------------------------QEEELM-----SLQMKQQRVELDHGTP 776

  Fly  1101 CSTSTL--DLLKTKPGDPIEMVTYS-ALPSVMESTSAMSSKRGSFVDTTLQFNSPQQFDYAVQSS 1162
            ..|..|  ||...:|  |:....|: ||....|....|::...|.:.:|:....|..
Zfish   777 LPTRGLHGDLEPLRP--PVCPPDYTLALRRAPEDVPLMTANTLSMIPSTITGMQPLH-------- 831

  Fly  1163 DQMSFKAIEDAVKAAAGHDS 1182
               :|.....|...:|||.:
Zfish   832 ---AFNTYPPAPAPSAGHSN 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	200/558 (36%)
nlgn2b	NP_001159808.1	COesterase	47..611	CDD:278561	213/663 (32%)
nlgn2b	NP_001159808.1	Aes	<181..>279	CDD:223730	49/98 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880