Protein Alignment Nha1 and NHX1

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_010744.3
• Gene: NHX1 / 852066
• SGDID: S000002864
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 554
• Identity: 99/554 - (17%)
• Similarity: 197/554 - (35%)
• Gaps: 140/554 - (25%)

  Fly   253 LFGLVVLTVAANFGGYLISL--------TTLPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRK 309
            ||.:::|.::|.:..|.::.        |.|....|| ::|::.:......|....:..:::...
Yeast    64 LFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGM-VIGLIIRMSPGHYIQDTVTFNSSYFFN 127

  Fly   310 FALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFLLDLPWIWAFL------- 367
            ..|..|:..:|.|:....|.....:||...|....:.|||:.:       :.:||.||
Yeast   128 VLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGI-------ILYIWTFLGLESIDI 185

  Fly   368 -------LGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAGVDDALSVAIF-------G 418
                   :|:.::|..|..::...     ..|.|...:.|::...:.::||:|:.:|       |
Yeast   186 SFADAMSVGATLSATDPVTILSIF-----NAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHG 245

  Fly   419 IISTVMFSDKGLAYQIAQAPVCILGGLGFGVVWGSL-----ARIFPEKGDAYVVPLR-------- 470
            ..:|.....:|....:....|.:|.|:..|::...|     .|.:|:.....::.:.
Yeast   246 QPATFSSVFEGAGLFLMTFSVSLLIGVLIGILVALLLKHTHIRRYPQIESCLILLIAYESYFFSN 310

  Fly   471 -------TLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFV---SNLFWCKDGWDVEDNPVSTAF 525
                   ..|||.|..:..|....:.......:..:|....   .|..:           :....
Yeast   311 GCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARLSENFIF-----------IYLGL 364

  Fly   526 EIFW---MIFEPILFGLTGATIKIRELDSHTVSIGAACIFTGAILRILT---TAGIAFGDRLNTK 584
            |:|.   ::::|:|..:...:|.:    :...::.....|...|.|:.|   .:||. |:.::..
Yeast   365 ELFTEVELVYKPLLIIVAAISICV----ARWCAVFPLSQFVNWIYRVKTIRSMSGIT-GENISVP 424

  Fly   585 EK---------FFVGLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAPL 640
            ::         |:.||        :.|:| |||. ||... |.:......|..:.|.::::....
Yeast   425 DEIPYNYQMMTFWAGL--------RGAVG-VALA-LGIQG-EYKFTLLATVLVVVVLTVIIFGGT 478

  Fly   641 GAIMISVTGTK-----------------------LLTKTKQPQDLSGWRRSHRPSIRDISIIDEE 682
            .|.|:.|...|                       ||..:....||..:..::.|   ||| ||:.
Yeast   479 TAGMLEVLNIKTGCISEEDTSDDEFDIEAPRAINLLNGSSIQTDLGPYSDNNSP---DIS-IDQF 539

  Fly   683 EEREDPEIPED-KETHDNTLNNAHIPSISYTYNT 715
            ....:..:|.: ..|..||..     .::.|.||
Yeast   540 AVSSNKNLPNNISTTGGNTFG-----GLNETENT 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	84/497 (17%)
NHX1	NP_010744.3	Na_H_Exchanger	55..611	CDD:470090	99/554 (18%)