Protein Alignment Nha1 and SLC9A7

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001244220.1
• Gene: SLC9A7 / 84679
• HGNCID: 17123
• Length: 726
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 90/437 - (20%)
• Similarity: 150/437 - (34%)
• Gaps: 93/437 - (21%)

  Fly   221 TVSRLISIILIG---VLIWV-----------TAFVIIGDSAAPGGQLFGLVV------LTVAANF 265
            :||.|..|:|:.   :.||:           |...:|          :||:|      .|.|.:.
Human    71 SVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMI----------YGLIVGVILRYGTPATSG 125

  Fly   266 GGYLISLTTLPRLIGMLLV---GILFQNVGWADID-GDFSKVTAH--LRK----------FALTI 314
            ....:|.|...|....|||   |..|:.....:|. |..:.|..:  |||          ..|..
Human   126 RDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPP 190

  Fly   315 ILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFLLDLPWIWAFL-----------L 368
            |:..||..::...|.:...:||....:...|...::..:.:.::.|..|...|           .
Human   191 IIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFF 255

  Fly   369 GSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAGVDDALSVAIFGIISTVMFSDKGLAYQ 433
            |:||:|..|..|:.....|...     ..:..|:...:.::||:::.:..  |.|.:...||...
Human   256 GAIISATDPVTVLAIFNELHAD-----VDLYALLFGESVLNDAVAIVLSS--SIVAYQPAGLNTH 313

  Fly   434 IAQAPV----------CILGGLGFGVVWGSLARIFPEKGDAYVVP-LRTLLLFTGGLMAIYGSEE 487
            ...|..          ...|....|.|.|.:..:..:....:..| |.|.|.|.........:|.
Human   314 AFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEA 378

  Fly   488 LGFEGAGPLAVVFSAFVSNLFWCKDGWDVED-NPVSTAFEIFWMIFEPILFGLTGATIKIRELDS 551
            .||.|.  :||:|.. ::...:..:...||. :.....||:...:.|..:|...|  :.:.....
Human   379 CGFTGV--VAVLFCG-ITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMG--LALFTFQK 438

  Fly   552 HTVS----IGA-ACIFTGAILRILTTAGIAFGDRLNTKEKFFVGLSW 593
            |..|    ||| ..||.|....|..   ::|...|..:.|    :.|
Human   439 HVFSPIFIIGAFVAIFLGRAAHIYP---LSFFLNLGRRHK----IGW 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	81/391 (21%)
SLC9A7	NP_001244220.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Na_H_Exchanger	93..>552	CDD:470090	83/415 (20%)
		Required for trans-Golgi network localization. /evidence=ECO:0000269|PubMed:20364249	534..560
		Required for trans-Golgi network localization. /evidence=ECO:0000269|PubMed:20364249	564..569
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	568..591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	670..715