Protein Alignment Nha1 and SLC9A5

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_004585.1
• Gene: SLC9A5 / 6553
• HGNCID: 11078
• Length: 896
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 118/585 - (20%)
• Similarity: 203/585 - (34%)
• Gaps: 200/585 - (34%)

  Fly   196 EEPSASWEPPFWQKIF---------PYPLCPTFRTVSRLISIIL-----IGVLIWVTAFVIIGDS 246
            ::|.:..|||...::|         || |...:..|:.|..|:.     :..|:..:..:|:
Human    22 QKPESPGEPPPGLELFRWQWHEVEAPY-LVALWILVASLAKIVFHLSRKVTSLVPESCLLIL--- 82

  Fly   247 AAPGGQLFGLVVLTVA--ANF----GGYLISLTTLPRLI---GMLLVG-ILFQNVGWADIDGDFS 301
               .|.:.|.:||.||  |.:    |.:.:.|  ||.::   |..:.. :.|.|:|
Human    83 ---LGLVLGGIVLAVAKKAEYQLEPGTFFLFL--LPPIVLDSGYFMPSRLFFDNLG--------- 133

  Fly   302 KVTAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVE--AVVMAVMSHFLLDLPWIW 364
                        .|||.|.:.....||        ..|...|.::  .:|...:...|||.
Human   134 ------------AILTYAVVGTLWNAF--------TTGAALWGLQQAGLVAPRVQAGLLDF---- 174

  Fly   365 AFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFGIISTVMFS 426
             .|.||:|:||.|..|:.....:...        .||.:.|.|   ::||::|.::.:.::  |.
Human   175 -LLFGSLISAVDPVAVLAVFEEVHVN--------ETLFIIVFGESLLNDAVTVVLYKVCNS--FV 228

  Fly   427 DKGLA--------YQIAQAPVCILGGLGFGVVWGSLARIFPE--KGDAYVVPLRTLLLFTGGLMA 481
            :.|.|        ..:|...|..|||...|:|:..|..:...  |....:.||...||    ..|
Human   229 EMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLL----AYA 289

  Fly   482 IYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDN-------PVSTAFEIFWMIFEPILFGL 539
            .|.:.|:     ..|:.:.:..:..| .||.  .||.|       .|....:......|.::|.|
Human   290 AYLTAEM-----ASLSAILAVTMCGL-GCKK--YVEANISHKSRTTVKYTMKTLASCAETVIFML 346

  Fly   540 TGATIKIRELDSHTVSIGAACIFTGAILRILTTAGIAFGDRLNTKEKFFVGLSWMAKATVQAALG 604
            .|    |..:||...:..:..:. |.::.||                ||            .|||
Human   347 LG----ISAVDSSKWAWDSGLVL-GTLIFIL----------------FF------------RALG 378

  Fly   605 PVALKHLGDDATEEERNWANIVQTICVFSIVLTAPLGAIMISVTGTK---------LLTKTKQP- 659
            .|.            :.|     .:..|.:|....:..:::|..|.:         ||.:||.|
Human   379 VVL------------QTW-----VLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPA 426

  Fly   660 ------------------QDLSGWRRSHRPSIRDISIIDEEEEREDPEIPEDKETHDNTLNNAHI 706
                              |.|     :.:|.::.:.:  :..|...|.:  ::|.|::|.:  ||
Human   427 KDYFVATTIVVVFFTVIVQGL-----TIKPLVKWLKV--KRSEHHKPTL--NQELHEHTFD--HI 480

  Fly   707  706
            Human   481  480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	94/467 (20%)
SLC9A5	NP_004585.1	Na_H_Exchanger	41..630	CDD:470090	113/566 (20%)
		Required for interaction with ARRB2. /evidence=ECO:0000269|PubMed:21296876	576..721
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..686
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..720
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..864