DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nha1 and SLC9A3

DIOPT Version :10

Sequence 1:NP_723224.2 Gene:Nha1 / 33961 FlyBaseID:FBgn0031865 Length:715 Species:Drosophila melanogaster
Sequence 2:NP_004165.2 Gene:SLC9A3 / 6550 HGNCID:11073 Length:834 Species:Homo sapiens


Alignment Length:588 Identity:107/588 - (18%)
Similarity:192/588 - (32%) Gaps:197/588 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 VVLTVAANFGGYLISLTT--LPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRKFALT------ 313
            :::...|..|.:|....|  :|....::::|::...:.||         ..|:..|.||      
Human    62 ILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWA---------ADHIASFTLTPTVFFF 117

  Fly   314 -----IILTRAGLEMEPEAFKKVYKTILKLGII--PWCVEAVVMAVMSHFL------LDLPWIWA 365
                 |:|. ||..|....|.....|||...::  .|......:::...||      |.:..:..
Human   118 YLLPPIVLD-AGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDF 181

  Fly   366 FLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFGIIST--VMF 425
            .|.||::|||.|..|:.....:...        ..|.:.|.|   ::||::|.::.:..:  .:.
Human   182 LLFGSLMAAVDPVAVLAVFEEVHVN--------EVLFIIVFGESLLNDAVTVVLYNVFESFVALG 238

  Fly   426 SD--------KGLAYQIAQAPVCILGGLGFGVVWGSL----------ARIFPEKGDAYVVP---- 468
            .|        ||    |....|..|||...|||:..|          .||. |.|..:::.    
Human   239 GDNVTGVDCVKG----IVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRII-EPGFVFIISYLSY 298

  Fly   469 LRTLLLFTGGLMAI---------YGSEELGFEGAGPL------------AVVFS----AFVSNLF 508
            |.:.:|....::||         |....:..:.|..:            .::|.    :.|:...
Human   299 LTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFI 363

  Fly   509 WCKDGWDVEDNPVSTAFEIFWMIFEPI--LFGLTGAT--------IKIRELDSHTVSIGAACIFT 563
            |.   |       :|||.:..::|..:  ..|:...|        :::..:|...:|.|.   ..
Human   364 WT---W-------NTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGG---LR 415

  Fly   564 GAILRILTTAGIAFGDRLNTKEKF-------------FVGLS------WM--------------- 594
            ||:...|..  :..||::..|..|             |.||:      |:               
Human   416 GAVAFALVV--LLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEK 478

  Fly   595 --------AKATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAPLGAIMISVTGTK 651
                    ..:.::...|.:...:|.|..:..:|.:.:.|                         
Human   479 LHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRV------------------------- 518

  Fly   652 LLTKTKQPQDLSGWRRSHRPSIRD-ISIIDEEEEREDPEIPEDKETHDNTLNNAHIP-------S 708
            |:.::.|..........|..:::| ||.:.|.|.|..........| ||.:|....|       |
Human   519 LMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPST-DNVVNVDFTPRSSTVEAS 582

  Fly   709 ISY 711
            :||
Human   583 VSY 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nha1NP_723224.2 NhaP 253..>661 CDD:439796 92/528 (17%)
SLC9A3NP_004165.2 b_cpa1 48..646 CDD:273294 107/588 (18%)
Interaction with EZR. /evidence=ECO:0000250|UniProtKB:P26432 575..589 3/11 (27%)
Interaction with NHERF4. /evidence=ECO:0000250|UniProtKB:P26432 590..667
Interaction with AHCYL1. /evidence=ECO:0000250|UniProtKB:P26432 591..695
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 679..728
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..834
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.