Protein Alignment Nha1 and Nhe2

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 133/678 - (19%)
• Similarity: 226/678 - (33%)
• Gaps: 189/678 - (27%)

  Fly    69 ESQPKRRVSIISD-----------PPMIGGNGGLGTGYDNPAYEQNPRRKISQTSTHSHTDIGPA 122
            ||..|...|:|:|           ||                    ||.|   |.|.....|.||
  Fly    36 ESLFKTYASVITDTSANEIDAEAPPP--------------------PRDK---TKTRIEPQIAPA 77

  Fly   123 RRKSILKDT----------------------------------APHDNESDRVSTHSYENYRQNA 153
            :|.|....:                                  ||.....|.|...:..|..|:|
  Fly    78 KRNSSCTSSDWRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSA 142

  Fly   154 -LDVLNAKYNGHQMGHNGGGSSNGGANYVEESWMYNFCLKCRGEEPSASWEPPFWQKIFPYPLCP 217
             :|.::.           |......|.......:.:.....:|:|         ..|:..|||..
  Fly   143 PIDAVDV-----------GLDPTPSARVPRPEPLKSGDENAKGDE---------GHKMERYPLSS 187

  Fly   218 TFRTVSRLISIILIGVLIWVTAFVIIGDSAAPGGQLFGLVVLTVAANFGGYLISLTTLPRLIGML 282
            .  ..:|:.:..:||:.|...:...||....|...|.                    .|....::
  Fly   188 V--DFARVKTPFIIGIWILSASIAKIGFHMTPKLHLI--------------------FPESCLLI 230

  Fly   283 LVGILFQNVGWADIDGDFSKVTAHLRKF-ALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVE 346
            :||::...|.:...|...|.:|.:...| .|..|:..||..|....|.....|||.:.::.....
  Fly   231 VVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFN 295

  Fly   347 AVV----------MAVMSHF----LLDLPWIWAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKG 397
            ...          |.:....    |:|:     ||..|:|:||.|..|:.....:...
  Fly   296 IATIGGSLYACGKMGIYGESETPGLMDV-----FLFASLISAVDPVAVLAVFEEIHVN------- 348

  Fly   398 IPTLVVAVAG---VDDALSVAIFGIISTV--MFSDKGLAYQIAQAP----VCILGGLGFGVVWGS 453
             ..|.:.|.|   ::||::|.::.::.:.  :..||.:|..||...    |..|||...|::||.
  Fly   349 -EILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGF 412

  Fly   454 LARIFPEKGDAYVVPLRTLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVED 518
            |..:.....| :|..:..:.:|....:|...:|.  |..:|.||:.|.......:       ||.
  Fly   413 LTGLVTRFTD-HVRVIEPIFIFVMAYLAYLNAEI--FHMSGILAITFCGITMKNY-------VES 467

  Fly   519 N-------PVSTAFEIFWMIFEPILFGLTG-ATIKIRELDSH-------TVSIGAACIFTGAILR 568
            |       .|..|.::.....|.|:|...| ||:.    :.|       .::|....:|  .::.
  Fly   468 NISQKSHTTVKYALKMLSSSAETIIFMFLGVATVN----NMHVWNTWFVVLTIAFCSVF--RVIG 526

  Fly   569 ILTTAGIAFGDRLNTKEKF--FVGLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTICV 631
            ::..:.:|...||:...:.  ||    |:...::.|:. .||..|.|:...:::|.. :..||.|
  Fly   527 VILLSALANRFRLHKLSRVDQFV----MSYGGLRGAVA-FALVLLVDENVVKQKNMF-VTTTIAV 585

  Fly   632 --FSIVLTAPLGAIMISVTGTKLLTKTK 657
              |::.|.......::.:...|...|.|
  Fly   586 IYFTVFLQGITIKPLVKILNVKRANKRK 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	92/448 (21%)
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	99/480 (21%)