Protein Alignment Nha1 and Slc9a8

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001020452.2
• Gene: Slc9a8 / 311651
• RGDID: 1308193
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 113/528 - (21%)
• Similarity: 187/528 - (35%)
• Gaps: 158/528 - (29%)

  Fly   254 FGLVVLTVAANFGGYLI--SLTTLPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRKFA----- 311
            |.|:||.:.......||  .|..||..:.::.:|||.         |...|| ...:|.|
  Rat    58 FSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILM---------GAVIKV-IEFKKLANWKEE 112

  Fly   312 ------------LTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFL------- 357
                        |..|:..:|..:....|.:...:|....:....:.|.|:....:||
  Rat   113 EMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVIS 177

  Fly   358 -LDLPWIWAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFG 418
             |::...:||  ||:|:||.|...:.....|...        |.|.:.|.|   ::||:|:.:..
  Rat   178 KLNMTDSFAF--GSLISAVDPVATIAIFNALHVD--------PVLNMLVFGESILNDAVSIVLTN 232

  Fly   419 I---ISTVMFSD--------KGLAYQIAQAPVCILGGLGFGVVWGSLARIFPEKGDAYVVPLRTL 472
            .   ::....||        :.|.|.:..    ..|....|.:.|.::.:..:.     :.||..
  Rat   233 TAEGLTRKHMSDVSGWQTFSQALGYFLKM----FFGSAALGTLTGLISALVLKH-----IDLRKT 288

  Fly   473 LLFTGGLMAI-----YGSEELGFEGAGPLAVVFSAFV------SNL----------------FWC 510
            .....|:|.|     ||..| |...:|.:|::||..|      .||                |.|
  Rat   289 PSLEFGMMIIFAYLPYGLAE-GISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLC 352

  Fly   511 KD------GWDVEDNPVSTAFEIFWMIFEPILFGLTGATIKIRELDSHTVSIGAACIFTGAILRI 569
            :.      |..:...|  ..|||.::|: .|:..|.|..:.|..| |:.::.
  Rat   353 ETCVFAFLGLSIFSFP--HKFEISFVIW-CIVLVLFGRAVNIFPL-SYLLNF------------- 400

  Fly   570 LTTAGIAFGDRLNTKEKFFVGLSWMAKATVQAALGPVALK-HLGDDATEEERNWANIVQTICVFS 633
                   |.|...|.:..|:  .|.  :.::.|: |.||. |||.:..|:.:........|.:|:
  Rat   401 -------FRDHKITPKMMFI--MWF--SGLRGAI-PYALSLHLGLEPMEKRQLIGTTTIIIVLFT 453

  Fly   634 IVLTAPLGAIMISVTGTKLLTKTKQPQDLSGWRRSHRPSIRDISI---------IDEEEEREDPE 689
            |:|   ||.      .|..|.:....:|    .|:.|.|.:|:::         |:.|...|..|
  Rat   454 ILL---LGG------STMPLIRLVDIED----ARARRRSKKDVNLSKTEKMGNAIESEHLSELTE 505

  Fly   690 IPEDKETH 697
              |:.|.|
  Rat   506 --EEYEAH 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	101/481 (21%)
Slc9a8	NP_001020452.2	Na_H_Exchanger	58..>482	CDD:470090	105/495 (21%)