Protein Alignment Nha1 and SLC9C1

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_898884.1
• Gene: SLC9C1 / 285335
• HGNCID: 31401
• Length: 1177
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 96/523 - (18%)
• Similarity: 205/523 - (39%)
• Gaps: 129/523 - (24%)

  Fly   256 LVVLTVAANFGGYL---ISLTTLPRLIGMLLVGILFQ--------------NVGWADIDGDFSKV 303
            ::.|::.::.|.:|   :....:|..:.:.|:|..|:              .:.|...|..|
Human    19 ILTLSLISSIGAFLNRHLEDFPIPVPVILFLLGCSFEVLSFTSSQVQRYANAIQWMSPDLFF--- 80

  Fly   304 TAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVV----MAVMSHFLLDLPWIW 364
                |.|...:..|.| .:|:....:|::..||.:.|..:.|..::    :|.::..||. |..|
Human    81 ----RIFTPVVFFTTA-FDMDTYMLQKLFWQILLISIPGFLVNYILVLWHLASVNQLLLK-PTQW 139

  Fly   365 AFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAGVDDALSVAIFGIISTVMFSDKG 429
             .|..:|:.:..|.:....:     :..|:::.:.:|:...:.:...:|:..|   :::|..|:.
Human   140 -LLFSAILVSSDPMLTAAAI-----RDLGLSRSLISLINGESLMTSVISLITF---TSIMDFDQR 195

  Fly   430 LA----YQIAQ---APVC--ILGGLGFGVV-------WGSLARIFPEKGDAYVVPLRTLLLFTGG 478
            |.    :.:|:   ..:|  |:....||::       |  ::.:|.:  |...:.|...:|:
Human   196 LQSKRNHTLAEEIVGGICSYIIASFLFGILSSKLIQFW--MSTVFGD--DVNHISLIFSILY--- 253

  Fly   479 LMAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDNPVSTAFEIFW---------MIFEP 534
             :..|..|.:|..|...||:|.....|..|...    :|:    |....||         |:|
Human   254 -LIFYICELVGMSGIFTLAIVGLLLNSTSFKAA----IEE----TLLLEFWTFLSRIAFLMVF-- 307

  Fly   535 ILFGLTGATIKIRELDSHT--------VSIGAACIFTGAILRILTTAGIA-----FGDRLNTKEK 586
            ..|||.        :.:||        :........|..:||.||...|:     .|...:.:..
Human   308 TFFGLL--------IPAHTYLYIEFVDIYYSLNIYLTLIVLRFLTLLLISPVLSRVGHEFSWRWI 364

  Fly   587 FFVGLSWM-AKATVQAALGPVALKHL--GDDATEEERNWANIVQTICVFSIVLTAPLGAIMISVT 648
            |.:..|.| ....:..|| .:|...|  |.|..:.:..:..::  :|:.::|:...:..:.:::.
Human   365 FIMVCSEMKGMPNINMAL-LLAYSDLYFGSDKEKSQILFHGVL--VCLITLVVNRFILPVAVTIL 426

  Fly   649 GTKLLTKTKQP---------QDLSGWRRSHRPSIR--------DISIIDEEEEREDPEIPEDKET 696
            |.:..|.||..         |:|:   :|...:::        |.::|::....|:|.:..::||
Human   427 GLRDATSTKYKSVCCTFQHFQELT---KSAASALKFDKDLANADWNMIEKAITLENPYMLNEEET 488

  Fly   697 HDN 699
            .::
Human   489 TEH 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	87/475 (18%)
SLC9C1	NP_898884.1	NhaP	17..538	CDD:439796	96/523 (18%)
		Transport core domain. /evidence=ECO:0000250|UniProtKB:A3RL54	104..191		16/96 (17%)
		Transport core domain. /evidence=ECO:0000250|UniProtKB:A3RL54	325..426		18/103 (17%)
		Ion transport-like	598..678
		Ion_trans	613..>726	CDD:459842
		CAP_ED	882..998	CDD:237999