Protein Alignment Nha1 and Slc9a5

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_006531127.1
• Gene: Slc9a5 / 277973
• MGIID: 2685542
• Length: 971
• Species: Mus musculus
• Alignment Length: 535
• Identity: 115/535 - (21%)
• Similarity: 186/535 - (34%)
• Gaps: 151/535 - (28%)

  Fly   177 GANYVEESWMYNFCLKCRGEEPSA----SWEPPFWQKI-FPYPLCPTFRTVSRLISIIL-----I 231
            ||...||....:..|   ||.|..    .|:   |.:: .|| |...:..|:.|..|:.     :
Mouse    16 GAGATEEPTQESGPL---GEPPPGLALFRWQ---WHEVEAPY-LVALWILVASLAKIVFHLSRKV 73

  Fly   232 GVLIWVTAFVIIGDSAAPGGQLFGLVVLTVA--ANF----GGYLISLTTLPRLI---GMLLVG-I 286
            ..|:..:..:|:      .|.:.|.:||.||  |.:    |.:.:.|  ||.::   |..:.. :
Mouse    74 TSLVPESCLLIL------LGLVLGGIVLAVAKKAEYQLEPGTFFLFL--LPPIVLDSGYFMPSRL 130

  Fly   287 LFQNVGWADIDGDFSKVTAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVE--AVV 349
            .|.|:|                     .|||.|.:.....||        ..|:..|.::  .:|
Mouse   131 FFDNLG---------------------AILTYAVVGTLWNAF--------TTGVALWGLQQAGLV 166

  Fly   350 MAVMSHFLLDLPWIWAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDA 411
            ...:...|||.     .|.||:|:||.|..|:.....:...        .||.:.:.|   ::||
Mouse   167 APRVQAGLLDF-----LLFGSLISAVDPVAVLAVFEEVHVN--------QTLFIIIFGESLLNDA 218

  Fly   412 LSVAIFGIISTVMFSDKGLA--------YQIAQAPVCILGGLGFGVVWGSLARIFPE--KGDAYV 466
            ::|.::.:.::  |.:.|.|        ..:|...|..|||...|:|:..|..:...  |....:
Mouse   219 VTVVLYKVCNS--FVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRII 281

  Fly   467 VPLRTLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDN-------PVSTA 524
            .||...||    ..|.|.:.|:     ..|:.:.:..:..| .||.  .||.|       .|...
Mouse   282 EPLLVFLL----AYAAYLTAEM-----ASLSAILAVTMCGL-GCKK--YVEANISHKSRTAVKYT 334

  Fly   525 FEIFWMIFEPILFGLTGATIKIRELDSHTVSIGAACIFTGAILRILTTAGIAFGDRLNTKEKFFV 589
            .:......|.::|.|.|    |..:||...:..:..:. |.:..||....:.....|.:...|
Mouse   335 MKTLASCAETVIFMLLG----ISAVDSSKWAWDSGLVL-GTLFFILFFRALGIAGALCSPVPF-- 392

  Fly   590 GLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAP---------LGA-IM 644
                         |.|:|..|....::...       |..|: ...||.|         ||| :.
Mouse   393 -------------LSPLAAPHPLSPSSHPH-------QFPCL-PAALTCPDPCQTLAQMLGAGLP 436

  Fly   645 ISVTGTKLLTKTKQP 659
            :|.|...||.....|
Mouse   437 VSSTPNSLLPLALPP 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	96/449 (21%)
Slc9a5	XP_006531127.1	Na_H_Exchanger	44..706	CDD:470090	106/501 (21%)