Protein Alignment Nha1 and Slc9a5

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_620213.1
• Gene: Slc9a5 / 192215
• RGDID: 620473
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 120/587 - (20%)
• Similarity: 199/587 - (33%)
• Gaps: 205/587 - (34%)

  Fly   196 EEPSASWEPP-------FWQKI-FPYPLCPTFRTVSRLISIIL-----IGVLIWVTAFVIIGDSA 247
            :||....|||       .|.:: .|| |...:..|:.|..|:.     :..|:..:..:|:
  Rat    25 QEPGPLGEPPGLALFRWQWHEVEAPY-LVALWILVASLAKIVFHLSRKVTSLVPESCLLIL---- 84

  Fly   248 APGGQLFGLVVLTVA--ANF----GGYLISLTTLPRLI---GMLLVG-ILFQNVGWADIDGDFSK 302
              .|...|.:||.||  |.:    |.:.:.|  ||.::   |..:.. :.|.|:|
  Rat    85 --LGLALGGIVLAVAKKAEYQLEPGTFFLFL--LPPIVLDSGYFMPSRLFFDNLG---------- 135

  Fly   303 VTAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVE--AVVMAVMSHFLLDLPWIWA 365
                       .|||.|.:.....||        ..|:..|.::  .:|...:...|||.
  Rat   136 -----------AILTYAVVGTLWNAF--------TTGVALWGLQQAGLVAPRVQAGLLDF----- 176

  Fly   366 FLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFGIISTVMFSD 427
            .|.||:|:||.|..|:.....:...        .||.:.|.|   ::||::..::.:.::  |.:
  Rat   177 LLFGSLISAVDPVAVLAVFEEVHVN--------ETLFIIVFGESLLNDAVTAVLYKVCNS--FVE 231

  Fly   428 KGLA--------YQIAQAPVCILGGLGFGVVWGSLARIFPE--KGDAYVVPLRTLLLFTGGLMAI 482
            .|.|        ..:|...|..|||...|:|:..|..:...  |....:.||...||    ..|.
  Rat   232 MGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLL----AYAA 292

  Fly   483 YGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDN-------PVSTAFEIFWMIFEPILFGLT 540
            |.:.|:     ..|:.:.:..:..| .||.  .||.|       .|....:......|.::|.|.
  Rat   293 YLTAEM-----ASLSAILAVTMCGL-GCKK--YVEANISHKSRTAVKYTMKTLASSAETVIFMLL 349

  Fly   541 GATIKIRELDSHTVSIGAACIFTGAILRILTTAGIAFGDRLNTKEKFFVGLSWMAKATV--QAAL 603
            |    |..:||...:..:..:. |.:..||                ||..|..:.:..|  |..|
  Rat   350 G----ISAVDSSKWAWDSGLVL-GTLFFIL----------------FFRALGVVLQTWVLNQFRL 393

  Fly   604 GPVALKHLGDDATEEERNWANIVQTICVFSIVLTAPLGAIMISVTGTKLLTKTKQP--------- 659
            .|:                ..|.|.:..:..:..|...|::|      ||.:||.|
  Rat   394 APL----------------DKIDQVVMSYGGLRGAVAFALVI------LLDRTKVPAKDYFVATT 436

  Fly   660 ---------------QDLSGW---RRS--HRPSIRDISIIDEEEEREDPEIPEDKETHDNTLNNA 704
                           :.|..|   :||  |:|::                   ::|.|::|.:
  Rat   437 IVVVFFTVIVQGLTIKPLVKWLRVKRSDYHKPTL-------------------NQELHEHTFD-- 480

  Fly   705 HI 706
            ||
  Rat   481 HI 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	94/465 (20%)
Slc9a5	NP_620213.1	Na_H_Exchanger	43..632	CDD:470090	115/569 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..692
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..888