Protein Alignment Nha1 and nhx-2

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_495614.4
• Gene: nhx-2 / 174242
• WormBaseID: WBGene00003730
• Length: 644
• Species: Caenorhabditis elegans
• Alignment Length: 595
• Identity: 119/595 - (20%)
• Similarity: 204/595 - (34%)
• Gaps: 173/595 - (29%)

  Fly   192 KCRGEE-------PSASWEPPFWQKI-FPYPLCPTFRTVSRLISIILIGVLIWVTAFVIIGDSAA 248
            :|..||       |.|.:|   |:.: .|..:|                  :|
 Worm    24 ECEEEEKEYPSRYPIAYFE---WENVKIPMTIC------------------LW------------ 55

  Fly   249 PGGQLFGLVVLTVAANFGGYLISL---TTLPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRK- 309
                |.|..:..:..|...:|..|   :.|..:|| |::||:|:.:|       .:|....|..
 Worm    56 ----LIGASIAKIIFNLIPHLNELFPDSALLIMIG-LIIGIIFKLIG-------VNKNAFFLESE 108

  Fly   310 ----FALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMA-------VMSHFLLDLPWI 363
                :.|..::..||..|....|...:.:||...:|......|.:|       :...|.::.|.:
 Worm   109 VFMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAIALSLWAISLTGLFSVETPLM 173

  Fly   364 WAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFGIISTVMF 425
            ...|.||:.|.|.|..|:.....|:..        ..|.:||.|   ::|.::|.::.:..|  |
 Worm   174 HMLLFGSVAADVDPVAVIVIFEELKVN--------EVLFIAVFGESLLNDGVAVVLYRMFLT--F 228

  Fly   426 SDKGLAYQI--------AQAPVCILGGLGFGVVWG---SLARIFPEKGDAYVVPLRTLLLFTGGL 479
            |:.|....|        ....|...||:|.|:::.   ||...|....:..|:....:|:..
 Worm   229 SEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLNSVFILILP--- 290

  Fly   480 MAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDNPVSTAF-EIFWMIFEPILFGLTGAT 543
            ...|...|| |..:..:|:||.......: |::..|.:....:.:| ::..:..|.::|...|.:
 Worm   291 YTCYLCGEL-FGLSSIMAIVFCGAAMRQY-CRENVDPDTVKATESFIKVLSLASETVIFVFLGLS 353

  Fly   544 IKIRELDSHTVSIG-----AACIFTGAILRILTTAGIAF------GDRLN--TKEKFFVGLSWMA 595
                     |||..     :..:.|.....|..|.|:..      ..|||  ||...|:    ||
 Worm   354 ---------TVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFI----MA 405

  Fly   596 KATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAPLGAI----------------- 643
            ...::.|:....:..:.|....:     |:..|.|:..|..|..|..|
 Worm   406 YGGLRGAIAYGLVVAIPDFIPGK-----NMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKKNVH 465

  Fly   644 ---MISVTGTKLLTKTKQ-PQDLSGWRRSHRPSIRDISIIDEEEEREDPEIPEDKETHDNTLNNA 704
               ||....::|:..|.. .:|::|::..|  .|||                     ..|.|||.
 Worm   466 SKNMIEHIYSELIDTTMAGMEDIAGFKGHH--WIRD---------------------SWNALNNN 507

  Fly   705 HIPSISYTYN 714
            ::..|....|
 Worm   508 YLRPILVNKN 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	97/471 (21%)
nhx-2	NP_495614.4	Na_H_Exchanger	42..549	CDD:470090	114/577 (20%)