Protein Alignment Nha1 and Nha2

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_061505099.1
• Gene: Nha2 / 1273645
• VectorBaseID: AGAMI1_004398
• Length: 572
• Species: Anopheles gambiae
• Alignment Length: 673
• Identity: 201/673 - (29%)
• Similarity: 306/673 - (45%)
• Gaps: 134/673 - (19%)

  Fly     8 MTATGEPEAREDPSVGGAPATITTPTTIIAPT--PIPVPS-DVPMPNS--NGSGNGAGNHRSTIV 67
            :|:..||||   |:..|..:..|.|.: .|||  |.|:|| |:.|..|  ..:.:||......:|
Mosquito    12 ITSVEEPEA---PARNGGSSVPTEPDS-RAPTTVPAPIPSIDLAMALSKREATTDGALPLTGMVV 72

  Fly    68 IESQ--------PKRRVSIISDPPMIGGNGGLGTGYDNPAYEQNPRRKISQTSTHSHTDIGPARR 124
            :.::        |.|..|     |.: ||||..:|...|          .:|:..:.
Mosquito    73 VTAETADTGDWHPVRTTS-----PSV-GNGGTISGSPTP----------GRTAAFAR-------- 113

  Fly   125 KSILKDTAPHDNESDRVSTHSYENYRQNALDVLNAKYNGHQMGHNGGGSSNGGANYVEESWMYNF 189
                                               ||..|
Mosquito   114 -----------------------------------KYISH------------------------- 118

  Fly   190 CLKCRGEEPSASWEPPFWQKIFPYPLCP----TFRTVSRLISIILIGVLIWVTAFVII-GDSAAP 249
                                     :||    ::.|.|:.::::|:...:|..|:.|: .:.:.|
Mosquito   119 -------------------------VCPSLVRSWPTTSQPLALLLLFAFLWAIAYAILPPELSEP 158

  Fly   250 GGQLFGLVVLTVAANFGGYLISLTTLPRLIGMLLVGILFQNVGWADIDGDFSKVTAHLRKFALTI 314
            .|.|..|..|.|.|...|.|:|||.||.::|||..|:|:.||||||..| :.:|...||:.||..
Mosquito   159 AGGLMRLAFLFVGAQACGVLVSLTGLPDMLGMLFWGVLYANVGWADFAG-YERVEVFLREMALVN 222

  Fly   315 ILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFLLDLPWIWAFLLGSIIAAVSPAV 379
            |:..|||.::.:|.:.:::.|::|.::|...|...:||:||:||.|||:|..|||.::.|:||.|
Mosquito   223 IMLLAGLGLDYDALRSLFRFIMQLTLVPTVAEVAAVAVLSHYLLALPWLWGVLLGLVVTAISPNV 287

  Fly   380 VVPCLFRLRTKGYGVAKGIPTLVVAVAGVDDALSVAIFGIISTVMFSDKGLAYQIAQAPVCILGG 444
            ||..|.|||.:..|:.|||.||::|:...:|.|::.:||:|..|:||...|..||.|.|:.|:.|
Mosquito   288 VVTVLLRLREERLGLNKGIHTLIIAMTSCNDVLAIFLFGVILGVIFSTGDLTSQILQGPIGIVIG 352

  Fly   445 LGFGVVWGSLARIFPEKGDAYVVPLRTLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFVSNLFW 509
            |.:|.:.|......|.....|...||..:....|.:::.||:::|:..||.|..:.:|||:...|
Mosquito   353 LVYGSLCGLALLYLPSYQAKYTNGLRFAMTALAGTLSVVGSKKVGYPSAGALGCIVTAFVAGTGW 417

  Fly   510 CKDGWDVEDNPVSTAFEIFWMIFEPILFGLTGATIKIRELDSHTVSIGAACIFTGAILRILTTAG 574
            .|.. ..|.|.||...::.|...:|:.|.|.|..:|...|:..||..|...:....:||::.:..
Mosquito   418 RKRP-PTECNEVSMYLDLLWKFLKPVSFSLIGKEVKFSVLEGETVLYGFVTLLVAVLLRLIASYL 481

  Fly   575 IAFGDRLNTKEKFFVGLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTICVFSIVLTAP 639
            ...|..||.|||.:|.|:...||||||||||.||.........:|...|..|..:.|.:|:||||
Mosquito   482 STVGSELNWKEKAYVTLAGFPKATVQAALGPAALDLARSVNATDEYGRAQTVLIVTVLAIILTAP 546

  Fly   640 LGA-IMISVTGTKLLTKTKQPQD 661
            ||| :||.:....|...|.:..|
Mosquito   547 LGALLMIKLAPRWLKRSTDERTD 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	154/408 (38%)
Nha2	XP_061505099.1	None