Protein Alignment Nha1 and Nhe1

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_061515684.1
• Gene: Nhe1 / 1269244
• VectorBaseID: AGAMI1_006232
• Length: 678
• Species: Anopheles gambiae
• Alignment Length: 740
• Identity: 145/740 - (19%)
• Similarity: 240/740 - (32%)
• Gaps: 243/740 - (32%)

  Fly     3 SSHKKMTATGEPEA----REDPSV-------GGAPATITTPTTIIAPTPIPVPSDVPMPNSNGSG 56
            :::::.|..|.|.|    ...|||       |.|..:.:|..|:.:.:|.|.|:     .:||:.
Mosquito    34 AANQRPTVPGSPGATGTTAASPSVVLAAIHHGNASVSASTVATVPSASPAPAPA-----TANGTA 93

  Fly    57 NGAGNHRSTIVIESQPKRRVSIISDPPMIGGNGGLGTGYDNPAYEQNPRRKISQTSTHSHTDIGP 121
            ..|                    :.||    |||                   .|||.|.| :.|
Mosquito    94 ATA--------------------TAPP----NGG-------------------NTSTSSAT-MSP 114

  Fly   122 ARRKSILKDTAPHDNESDRVSTHSYENYRQNALDVLNAKYNGHQMGHNGGGSSNGGANYVEESWM 186
                           |...|....|.:
Mosquito   115 ---------------EKSAVEQEHYSS-------------------------------------- 126

  Fly   187 YNFCLKCRGEEPSASWEPPFWQKIFPYPLCPTFRTVSRLISIILIGVLI----WVTAFVIIGDSA 247
                                 ..|| :.||           :|.:|:|:    ..|.|..:.:|
Mosquito   127 ---------------------MSIF-FVLC-----------VIALGILLIHMMLQTGFQYLPES- 157

  Fly   248 APGGQLFGLVVLTVAANFGGYLISLTTLPRLIGMLL-VGILFQNVGWADIDGDFSKVTAHLRKFA 311
                    :||:.:.|              |||::| |..:.....| :.:..||.....|  ..
Mosquito   158 --------IVVVFLGA--------------LIGLILNVSSVKHIANW-EREEVFSPTAFFL--VL 197

  Fly   312 LTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVMAVMSHFLLDLP-------WIWAFLLG 369
            |..|:..:|..:....|.:...:||...||...:.|:|:. ...:||.|.       ::.:|..|
Mosquito   198 LPPIIFESGYNLHKGNFFQNIGSILVFAIIGTTISALVIG-SGVYLLGLAEVAYRLNFVESFAFG 261

  Fly   370 SIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG---VDDALSVAIFGIISTV--MFSDKG 429
            |:|:||.|...|.....|...        |.|.:.|.|   ::||:|:.   :.:||  |.||.|
Mosquito   262 SLISAVDPVATVAIFHALDVD--------PVLNMLVFGESILNDAISIV---LTTTVMPMVSDSG 315

  Fly   430 --LAYQIAQA--PVCIL--GGLGFGVVWGSLARIFPEKGDAYVVP---LRTLLLFTGGLMAIYGS 485
              ....|..|  ..|::  ...|.|||:..::.:..:..|....|   ...:|:||   .|.|..
Mosquito   316 SSTGESIFSALNTFCMMFFASAGIGVVFALMSALLLKHVDLRKHPSLEFGLMLVFT---YAPYVL 377

  Fly   486 EELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDNPVSTAFEIFWMIFEPILFGLTGATI---KIR 547
            .| |...:|.:|::|...|.:.:...:...|....:.........|.|..:|...|..|   |.|
Mosquito   378 AE-GIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHR 441

  Fly   548 ELDSHTVSIGAACIFTGAILRILTTAGIA--FGDRLNTKEKFFVGLSWMAKATVQAALGPVALKH 610
            ...|..:.....|:. |....|...|.:.  |.:...|....|:  .|.  :.::.|:......|
Mosquito   442 CELSFVIWAIVLCLI-GRACNIFPLAWLVNRFREHKITNRMAFI--MWF--SGLRGAISYALSLH 501

  Fly   611 LGDDATEEERNWANIVQTICVFSIVLTAPLGA----IMISVTGTKLLTKTKQPQDLSGWRRSHRP 671
            : ..:|||.|:  .::.|..:..:..|...|.    :|..:.|.|.:.:|.:.......|:....
Mosquito   502 M-QFSTEESRH--VVITTTLIIVLFTTLFFGGSTMPLMKYLQGGKKVKRTARAGRAGRKRKEKAL 563

  Fly   672 SI------------RDISIIDEEEE 684
            |:            ..:|.:.||||
Mosquito   564 SLSKTREWGQAIDSEHLSELTEEEE 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	97/438 (22%)
Nhe1	XP_061515684.1	None