Protein Alignment Nha1 and SLC9A6

DIOPT Version :10

• Sequence 1: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001425671.1
• Gene: SLC9A6 / 10479
• HGNCID: 11079
• Length: 731
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 114/555 - (20%)
• Similarity: 181/555 - (32%)
• Gaps: 161/555 - (29%)

  Fly   217 PTFRTVSRLISIIL-IGVLIWVTAFVIIGDSAAPGGQ---------------------------- 252
            |..|.:.|.:.::| :||..|.      |.|...||:
Human    19 PRARRLMRPLWLLLAVGVFDWA------GASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIF 77

  Fly   253 --LFGLVVLTV------AANFGGYLISLTTLPRLIGMLLVGILFQ----------NVGWA----- 294
              |..|.:||:      .|.|    :..|.|..:.| ||||::.:          ||..:
Human    78 ILLLTLTILTIWLFKHRRARF----LHETGLAMIYG-LLVGLVLRYGIHVPSDVNNVTLSCEVQS 137

  Fly   295 -------DIDGDF------SKVTAH----------LRK----------FALTIILTRAGLEMEPE 326
                   ::.|.|      .::::|          |||          ..|..|:..||..::..
Human   138 SPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR 202

  Fly   327 AFKKVYKTILK---LG----------IIPWCVEAVVMAVMSHFLLDLPWIWAFLLGSIIAAVSPA 378
            .|.:...:||.   ||          |:..||  .:|.|......|..:....|.|:|::|..|.
Human   203 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCV--TLMKVTGQLAGDFYFTDCLLFGAIVSATDPV 265

  Fly   379 VVVPCLFRLR--TKGYGVAKGIPTLVVAVAGVDDALSVA---------IFGIISTVMFSDKGLAY 432
            .|:.....|:  .:.|.:..|...|..|||.|..:..||         .|.:  |.||...|:..
Human   266 TVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDV--TAMFKSIGIFL 328

  Fly   433 QIAQAPVCILGGLGFGVVWGSLARIFPEKGDAYVVPLRTLLLFTGGLMAIYG------SEELGFE 491
            .|......:  |...|||...:.:.         ..||...|...||..:..      :|..||.
Human   329 GIFSGSFAM--GAATGVVTALVTKF---------TKLREFQLLETGLFFLMSWSTFLLAEAWGFT 382

  Fly   492 GAGPLAVVFSAFVSNLFWCKDGWDVEDNPVSTAFEIFWMIFEPILFGLTGATIKIRELDSH---- 552
            |.  :||:|.......:...:......:.....||:...:.|..:|...|.|  :....:|
Human   383 GV--VAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLT--LFTFQNHVFNP 443

  Fly   553 TVSIGA-ACIFTGAILRILTTAGIAFGDRLNTKEKFFVGLSWMAKATVQAALGPVALK-HLGDDA 615
            |..:|| ..||.|....|...:.:     ||...:..:|.::..........|.:|.. .:.|.|
Human   444 TFVVGAFVAIFLGRAANIYPLSLL-----LNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA 503

  Fly   616 TEEERNWAN-----IVQTICVFSIVLTAPLGAIMI 645
            |...:...:     :..|:.||....||.|..:.|
Human   504 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHI 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	103/488 (21%)
SLC9A6	NP_001425671.1	None