DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k09022 and UTP10

DIOPT Version :9

Sequence 1:	NP_609079.2	Gene:	l(2)k09022 / 33960	FlyBaseID:	FBgn0086451	Length:	2096	Species:	Drosophila melanogaster
Sequence 2:	NP_012426.1	Gene:	UTP10 / 853335	SGDID:	S000003645	Length:	1769	Species:	Saccharomyces cerevisiae

Alignment Length:	2267	Identity:	466/2267 - (20%)
Similarity:	838/2267 - (36%)	Gaps:	673/2267 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALAQQLQKLAAPQSSVTLADARSR-----ASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPA 62
            ::|:.||.::|:..::|.| |.:.|     ||::::.|.|||:|...|:|.....|:||:...|.
Yeast     2 SSLSDQLAQVASNNATVAL-DRKRRQKLHSASLIYNSKTAATQDYDFIFENASKALEELSQIEPK 65

  Fly    63 FKEFQLTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEY 127
            |..|..|||.|::::|:|:|:..|..|.||.||..:|.|.|....|.|...|.|||:||||:|..
Yeast    66 FAIFSRTLFSESSISLDRNVQTKEEIKDLDNAINAYLLLASSKWYLAPTLHATEWLVRRFQIHVK 130

  Fly   128 NRSEVMALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPL----------QRPGVPLAKTAIINR 182
            |...::...|.|::|.:|.:|:..::          |.||          ::|  |.|.|.|  :
Yeast   131 NTEMLLLSTLNYYQTPVFKRILSIIK----------LPPLFNCLSNFVRSEKP--PTALTMI--K 181

  Fly   183 AASNPAFLGFICQSTQKAVKELGPRAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRG 247
            ..::..||........:.:|......:||......:..||.......:.|... :..:||...:.
Yeast   182 LFNDMDFLKLYTSYLDQCIKHNATYTNQLLFTTCCFINVVAFNSNNDEKLNQL-VPILLEISAKL 245

  Fly   248 LISDNIDFMAAAYVIVAQLVSRTKLKSKVCNALLERVANCPFERLHSESLLLLVC-IYG--KQQA 309
            |.|.:.|...||:.|:....:...||..:..|.:|.:.:....:....|.||.:| ::.  |.|.
Yeast   246 LASKSKDCQIAAHTILVVFATALPLKKTIILAAMETILSNLDAKEAKHSALLTICKLFQTLKGQG 310

  Fly   310 ALPHFKPETILNLVGKKW-LISTLSSLAKGNIAIQSICMPLMTGAVAAI-RDDDASSN------- 365
            .:... |..|..|...|: .:|.|:.|.|.:   :.:|...:|....:| |.|.:..|
Yeast   311 NVDQL-PSKIFKLFDSKFDTVSILTFLDKED---KPVCDKFITSYTRSIARYDRSKLNIILSLLK 371

  Fly   366 -------SCKLFLDNL--LSEVPMPKPTAQQLINCFLDTYVETAIDAPEPME------------- 408
                   ..:|.:.:|  |||:...|....:|...|:....:..:...:.:.
Yeast   372 KIRLERYEVRLIITDLIYLSEILEDKSQLVELFEYFISINEDLVLKCLKSLGLTGELFEIRLTTS 436

  Fly   409 --TNSNEDDDTIVIDSDDEIETEKTTFQAWYSTYLEK---------------LERRYPEAFDL-- 454
              ||::.:.| ||....|.:||.|.. .|.:.|:|:|               ...||.:...|
Yeast   437 LFTNADVNTD-IVKQLSDPVETTKKD-TASFQTFLDKHSELINTTNVSMLTETGERYKKVLSLFT 499

  Fly   455 -SVKEALRSKSSTSNRQKALKLALGFRLNTTDEKAKHAYEKLYHYSADWRLSAVQKLLQNLNVTK 518
             ::.:..::.|..::....|:..:.|.|..|...|.....||.      .|:.:.|.:.::
Yeast   500 EAIGKGYKASSFLTSFFTTLESRITFLLRVTISPAAPTALKLI------SLNNIAKYINSI---- 554

  Fly   519 KRERSVKLLQECLPDRINDDSGAV---VSTLLSLPTEELAEMLGPLPLAQTLCHLLYRAQSEKDE 580
            ::|.::..|..||...:.|.|..|   |..:|||
Yeast   555 EKEVNIFTLVPCLICALRDASIKVRTGVKKILSL------------------------------- 588

  Fly   581 EWQPVVPLAVRHLTS--ALVSGSYDTNLVLLALMPLLFPGEALAEHQHKALRILLGSDFVSKVPF 643
                   :|.|..|.  .|....|..|:.:    |:|.|.:
Yeast   589 -------IAKRPSTKHYFLSDKLYGENVTI----PMLNPKD------------------------ 618

  Fly   644 LAELKVSNKFSDFNVGEHRQHFLDIIASSNQELS------SQERALLQSVEDHGGELYIQKASQL 702
             :|..:|.             ||:...:.|.::|      ..|:..|.        .:..:|
Yeast   619 -SEAWLSG-------------FLNEYVTENYDISRILTPKRNEKVFLM--------FWANQA--- 658

  Fly   703 THLLLLLTAYAKRELQPRESLHMLEKIGLYSRRLQFRVVNGSQNTQNCAPLQLYVDFLLTLVKNT 767
               ||:.:.|||..|     |..|.|...|:....                .|:.:|:...::|
Yeast   659 ---LLIPSPYAKTVL-----LDNLNKSPTYASSYS----------------SLFEEFISHYLEN- 698

  Fly   768 KWTALASTPWNQMTDELRLCLRLLEIICAQVFSEKADQPERQEWTRALQQSLQLILPEAQDRLEV 832
                                                    |..|.::.              :..
Yeast   699 ----------------------------------------RSSWEKSC--------------IAN 709

  Fly   833 LSNFYVFERLPELWPRDSDYAVFRLQGFIILEAVLSNPKSQIDCGLVHVLRVANACGSPLQTLRV 897
            .:||..|||
Yeast   710 KTNFEHFER-------------------------------------------------------- 718

  Fly   898 QAINILQLISNRKLVSHVEQLVRSLLQRKSELSMDHEQYALILYTILEPEKATAKERLVLSKLKR 962
               :::.|:|.::..|.:...|      .|.|:.|:||.|.|           |.|||:
Yeast   719 ---SLVNLVSPKEKQSFMIDFV------LSALNSDYEQLANI-----------AAERLI------ 757

  Fly   963 SVLALASDPKQSPICTASLLAALKHVNDENFLNELLPLGLDSLKTITAGEDNQNIKQ-LPWPHSE 1026
                             |:.|:|.:......:..:    :||...:.:..|...:.| ||. .|:
Yeast   758 -----------------SIFASLNNAQKLKIVQNI----VDSSSNVESSYDTVGVLQSLPL-DSD 800

  Fly  1027 IYKSVIERFEGRVALNVLLRKDLAWKLFEDSFAQYDTYVQLEQKLQPLPCVLLNSLTPETFEQMH 1091
            |:.|::.:                                             ||::.|..:...
Yeast   801 IFVSILNQ---------------------------------------------NSISNEMDQTDF 820

  Fly  1092 AKHKIALIKLIVESATNSDNDSIFLASHRLLKRCRLDCQPLVPILLEMANTKVEKKQPVKRRSVQ 1156
            :|.:         ...:|.:.:.||                                  |....|
Yeast   821 SKRR---------RRRSSTSKNAFL----------------------------------KEEVSQ 842

  Fly  1157 ATQLDLTSPYWKQGMTLLELLEHKKQLVGAELLIPPLFELLQACLTMEEHSAAE--YPKQLILSS 1219
            ..:|.|     ::...:||.|: |.:.||:|.|:..|..||....|:::.....  |.::.::|.
Yeast   843 LAELHL-----RKLTIILEALD-KVRNVGSEKLLFTLLSLLSDLETLDQDGGLPVLYAQETLISC 901

  Fly  1220 LLHCCQTAQSAGVQLVKAMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLHKIV 1284
            .|:.....:..|...:     ::.|.:::|.::||:.:||.|...||.:...|.:..:.:||.::
Yeast   902 TLNTITYLKEHGCTEL-----TNVRADILVSAIRNSASPQVQNKLLLVIGSLATLSSEVILHSVM 961

  Fly  1285 EIFTFVGSTVARHDDAFSLHIIHNVVESIIPILLLNTGHNEL--VIPVLKVFADICTDVPVHRRL 1347
            .||||:|:...|.||.|:..::...:.:::|.|:.|:..||.  :..:|..|......||.|||:
Yeast   962 PIFTFMGAHSIRQDDEFTTKVVERTILTVVPALIKNSKGNEKEEMEFLLLSFTTALQHVPRHRRV 1026

  Fly  1348 PLYATLFRVLEPKEHLWQFLCIIFESQVLLEQVPQKVSTDKSRLDFAREL--TLMFEDPTVAIQT 1410
            .|::||.:.|:|.:.|..||.:|.: |.....|..|:...:..::|.:.|  .|...:....:..
Yeast  1027 KLFSTLIKTLDPVKALGSFLFLIAQ-QYSSALVNFKIGEARILIEFIKALLVDLHVNEELSGLND 1090

  Fly  1411 CIRLLDYLAKLPATKSS------------LSGG----SGSSVLS---------------TEQQLF 1444
               |||.:..|.::|||            .|.|    |.|..|:               |:|..:
Yeast  1091 ---LLDIIKLLTSSKSSSEKKKSLESRVLFSNGVLNFSESEFLTFMNNTFEFINKITEETDQDYY 1152

  Fly  1445 DVRTRTFKQLRHYKY-LIMDFLSGISSCNEWEKKMKRPDPNE---LLPYYQEFILKT-LAYVGVL 1504
            |||    :.||...| :::|..|        :||:.|....|   ||.....||... |.:..:.
Yeast  1153 DVR----RNLRLKVYSVLLDETS--------DKKLIRNIREEFGTLLEGVLFFINSVELTFSCIT 1205

  Fly  1505 NGALEAASETPSLEKFWRVLANHAHD-------VLDNAIGLLAPQHFISVITELLK-HDHVYVRI 1561
            :...|.||::.:      .|::|..:       ||.|.:.:|....|::.:..||. ..:..:|.
Yeast  1206 SQENEEASDSET------SLSDHTTEIKEILFKVLGNVLQILPVDEFVNAVLPLLSTSTNEDIRY 1264

  Fly  1562 KVMDLLVTKLSPSSDYFQQSNAEHFGVLFAPLQEIINGILEGSSNSAQQAKLQQTALHALQLLAL 1626
            .:..::.:|       |:...:|...:    :..::..:|:.....::...:.|..|:.:..|..
Yeast  1265 HLTLVIGSK-------FELEGSEAIPI----VNNVMKVLLDRMPLESKSVVISQVILNTMTALVS 1318

  Fly  1627 RHGRDYIEECRSLLATLTKITKR-RANVPKAVVGNVVLTLVEICAS-LKAHALAQLPKFAPQLTE 1689
            ::|:..  |...|...||..|:: .:::.:..:.:  |.|:..|.. |...::|..||..|...:
Yeast  1319 KYGKKL--EGSILTQALTLATEKVSSDMTEVKISS--LALITNCVQVLGVKSIAFYPKIVPPSIK 1379

  Fly  1690 L-----------LKEQVHQMASL-------KQGPDYVCSTLVTALHKLFKALPLFLGPYLVDIIG 1736
            |           ||||: |:|.|       |:.|.::.|.::..||.::.:..       ||...
Yeast  1380 LFDASLADSSNPLKEQL-QVAILLLFAGLIKRIPSFLMSNILDVLHVIYFSRE-------VDSSI 1436

  Fly  1737 GLARLSVQLENPQLLQDKRTQVLKQKLADVWSAVAQGVEVRILVPSCAKAFSSLLEQQAYDELGH 1801
            .|:.:|:.:||..|     .:||| .|..:||.........:.|    ..|.|.||.
Yeast  1437 RLSVISLIIENIDL-----KEVLK-VLFRIWSTEIATSNDTVAV----SLFLSTLES-------- 1483

  Fly  1802 LMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNFRLQVRGLGLQRQLVSDVEASITETFVTWIL 1866
                 .::::...||....|:   ..:|.|....||   .........:|.:|||:.|...:::|
Yeast  1484 -----TVENIDKKSATSQSPI---FFKLLLSLFEFR---SISSFDNNTISRIEASVHEISNSYVL 1537

  Fly  1867 KLSETSFRPMYSRVHKWALES--------TSRETRLTYFLLTNRIAEALKSLFVLFASDFVEDSS 1923
            |:::..|||::..:.:||.:.        |..|..|.:|...|::.|.|:.:...:.:..:|...
Yeast  1538 KMNDKVFRPLFVILVRWAFDGEGVTNAGITETERLLAFFKFFNKLQENLRGIITSYFTYLLEPVD 1602

  Fly  1924 RLLTEHNSIRPEFEVEEREDDVDLLMAILNTLHHVFLYCSEDF-INDHRFNVLMPPLVNQLENDL 1987
            .||...        :.:..::|:|...::|:|.....:..::: .:..||.::...|||||.|
Yeast  1603 MLLKRF--------ISKDMENVNLRRLVINSLTSSLKFDRDEYWKSTSRFELISVSLVNQLSN-- 1657

  Fly  1988 VLGNESLQQVLSNCIAQF------AVATN----DVMWKQLNSQVL--LKTRTSNPEVRILAFNSC 2040
                      :.|.|.::      |:|:|    |...:.||..::  :|...|:.| ::.|..:.
Yeast  1658 ----------IENSIGKYLVKAIGALASNNSGVDEHNQILNKLIVEHMKASCSSNE-KLWAIRAM 1711

  Fly  2041 VAIARKLGESYAALLPETVPFIAELLEDEHQRVEKNTRTG-VQELETILGESVQKYL 2096
            ..|..|:|||:..|||:.||.|||||||:.:.:|:..||| |:.:|.:|||...:||
Yeast  1712 KLIYSKIGESWLVLLPQLVPVIAELLEDDDEEIEREVRTGLVKVVENVLGEPFDRYL 1768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..350	CDD:289183	27/117 (23%)
l(2)k09022	NP_609079.2	BP28CT	1818..1966	CDD:214987	31/155 (20%)
UTP10	NP_012426.1	U3snoRNP10	231..355	CDD:403559	29/128 (23%)
UTP10	NP_012426.1	BP28CT	1490..1637	CDD:214987	33/160 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344923
Domainoid	1	1.000	95	1.000	Domainoid score	I1659
eggNOG	1	0.900	-	-		E1_KOG1837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004191
OrthoInspector	1	1.000	-	-		oto100135
orthoMCL	1	0.900	-	-		OOG6_102005
Panther	1	1.100	-	-	LDO	PTHR13457
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1613
SonicParanoid	1	1.000	-	-		X4007
TreeFam	1	0.960	-	-
	12	11.870