DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k09022 and HEATR1

DIOPT Version :9

Sequence 1:	NP_609079.2	Gene:	l(2)k09022 / 33960	FlyBaseID:	FBgn0086451	Length:	2096	Species:	Drosophila melanogaster
Sequence 2:	NP_060542.4	Gene:	HEATR1 / 55127	HGNCID:	25517	Length:	2144	Species:	Homo sapiens

Alignment Length:	2261	Identity:	637/2261 - (28%)
Similarity:	1061/2261 - (46%)	Gaps:	287/2261 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQ 67
            |:||||||:||.|||..:|......||:|||||||||.||.:.:.||.|||:||...:|:|::|:
Human     2 TSLAQQLQRLALPQSDASLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFE 66

  Fly    68 LTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEV 132
            ..||.:...||||||:...:||.||..|:.||..||||.||:||....|||:.||.:|.||:..:
Human    67 APLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSL 131

  Fly   133 MALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQST 197
            :|.:||||||.|||::::.:::.:|...|:||.|:::.||||||..:|.....:..|:.|||...
Human   132 IACVLPYHETRIFVRVIQLLKINNSKHRWFWLLPVKQSGVPLAKGTLITHCYKDLGFMDFICSLV 196

  Fly   198 QKAVK---ELGPRAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMAAA 259
            .|:||   |....:.||:..:.|||:.:|.||..|:.:.|..|..:...:.:||.|...|:.||.
Human   197 TKSVKVFAEYPGSSAQLRVLLAFYASTIVSALVAAEDVSDNIIAKLFPYIQKGLKSSLPDYRAAT 261

  Fly   260 YVIVAQLVSRTKLKSKVCNALLERVAN--CPFERLHSESLLLLVCIYGKQ------QAALPHF-- 314
            |:|:.|:..:..:::...|:|..::..  .....|..:.|..|:.:..:|      :...||.
Human   262 YMIICQISVKVTMENTFVNSLASQIIKTLTKIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCN 326

  Fly   315 KPE--TILNLVGKKWLISTLSSLAKGNIAIQSICMPLMTGAVAAIRDDDASSNSCKLFLDNLLSE 377
            .|:  |||:.:.:.:.:|.|......::.:..|      ..|.....:.......|..|:.:|::
Human   327 VPDLITILHGISETYDVSPLLHYMLPHLVVSII------HHVTGEETEGMDGQIYKRHLEAILTK 385

  Fly   378 VPMPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDTIVIDSDDEIETEKTT-FQAWYSTYL 441
            :.:.......|.:...:.|:.                     ..|.:|:::.|.: ....:...:
Human   386 ISLKNNLDHLLASLLFEEYIS---------------------YSSQEEMDSNKVSLLNEQFLPLI 429

  Fly   442 EKLERRYPEAFDLSVKEALRSKSSTSNRQKALKLALGFRLNTTDEKAKHAYE-------KLYHYS 499
            ..||.:||...|:.::|.|:..:....::...:..   .|:|:..|.:...:       .|.|..
Human   430 RLLESKYPRTLDVVLEEHLKEIADLKKQELFHQFV---SLSTSGGKYQFLADSDTSLMLSLNHPL 491

  Fly   500 ADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLGPLPLA 564
            |..|:.|:.. |:.:..|.|.......::|.:..|:.||:..||.:.:| ..|...|........
Human   492 APVRILAMNH-LKKIMKTSKEGVDESFIKEAVLARLGDDNIDVVLSAIS-AFEIFKEHFSSEVTI 554

  Fly   565 QTLCHLLYRAQSEKDEEWQPVVPLAVRHLTSALVSGSYD--TNLVLLALMPLLFPGEALAEHQHK 627
            ..|.:|..||:..|:.||..|:.:|...|....:....|  :|.|::.|:|.:.......|....
Human   555 SNLLNLFQRAELSKNGEWYEVLKIAADILIKEEILSENDQLSNQVVVCLLPFMVINNDDTESAEM 619

  Fly   628 ALRILLG-SDFVSKVPFLA--ELKVSNKFSDFN----VGEHRQHFLDIIASSNQELSSQERALLQ 685
            .:.|.|. |...|..|.|.  |..:.|......    :|...|..::::| .|..|.... ::|:
Human   620 KIAIYLSKSGICSLHPLLRGWEEALENVIKSTKPGKLIGVANQKMIELLA-DNINLGDPS-SMLK 682

  Fly   686 SVED---HGGELYIQKASQLT-HLLLLLTAYAKRELQPRESLHMLEKIGLYSRRLQ--FRVVNGS 744
            .|||   .|.|.......::| |::|.:.......|:.......:....|..::::  ..|:...
Human   683 MVEDLISVGEEESFNLKQKVTFHVILSVLVSCCSSLKETHFPFAIRVFSLLQKKIKKLESVITAV 747

  Fly   745 QNTQNCAPLQLYVDFLLTL-VKNTKWT----ALASTPWNQMTDELRLCLRLLEIICAQVFSEKAD 804
            :     .|.:.:::.:|.. :....|.    .|.||....:.|.:.|...|.:.|    ::.||.
Human   748 E-----IPSEWHIELMLDRGIPVELWAHYVEELNSTQRVAVEDSVFLVFSLKKFI----YALKAP 803

  Fly   805 Q--PERQEWTRALQQSLQLILPEAQDRLEVLSN-----------------------------FYV 838
            :  |:...|....|     :..:::|.|.:|..                             |.:
Human   804 KSFPKGDIWWNPEQ-----LKEDSRDYLHLLIGLFEMMLNGADAVHFRVLMKLFIKVHLEDVFQL 863

  Fly   839 FERLPELWPRDSDYA---------VFRLQGFIILEAVLSNPKSQ-------IDCGLVHVLRVANA 887
            |:....||...|..:         |.:.|...:..|:||:.|:|       |...:|..|.:  .
Human   864 FKFCSVLWTYGSSLSNPLNCSVKTVLQTQALYVGCAMLSSQKTQCKHQLASISSPVVTSLLI--N 926

  Fly   888 CGSPLQTLRVQAINILQLISNRKLVSHVEQLVRSLLQRKSELSMDHE---QYALILYTILEPEKA 949
            .|||::.:|..||..||.:|.  :.|....::..|:.:..|::.|..   |....|:..|:.||.
Human   927 LGSPVKEVRRAAIQCLQALSG--VASPFYLIIDHLISKAEEITSDAAYVIQDLATLFEELQREKK 989

  Fly   950 TAKERLVLSKLKRSVLALASDPKQSPICTASLLAALKHVNDENFLNELLPLGLDSLKTITAGEDN 1014
            ....:.:...||..:..:.|.|.   .....|:..|:.||.|..|::|||:....|
Human   990 LKSHQKLSETLKNLLSCVYSCPS---YIAKDLMKVLQGVNGEMVLSQLLPMAEQLL--------- 1042

  Fly  1015 QNIKQLPWPHSEIYKSVIERFEGRVALNVLLRK--DLAWKLFEDSFAQYDTYV-------QLEQK 1070
            :.|::.|        :.:.:.|..| |::.|.|  :.:..|..:.....|.::       :|...
Human  1043 EKIQKEP--------TAVLKDEAMV-LHLTLGKYNEFSVSLLNEDPKSLDIFIKAVHTTKELYAG 1098

  Fly  1071 LQPLPCVLLNSLTPETF-----EQMHAKHKIALIKLIVESATNSDN-------DSIFLASHRLLK 1123
            :..:....|..:|...|     |::..|    |::::.:...|..|       .|:|.......:
Human  1099 MPTIQITALEKITKPFFAAISDEKVQQK----LLRMLFDLLVNCKNSHCAQTVSSVFKGISVNAE 1159

  Fly  1124 RCRLDCQPLVPILLEMANT----KVEKKQPVKRRSVQATQLDLTSPYWKQGMTLLELLEHKKQLV 1184
            :.|::.:|  |...:...|    :.:|.|..|.:.:::.| ::...||::...:||||:|||:|.
Human  1160 QVRIELEP--PDKAKPLGTVQQKRRQKMQQKKSQDLESVQ-EVGGSYWQRVTLILELLQHKKKLR 1221

  Fly  1185 GAELLIPPLFELLQACL--TMEEHSAAEYPKQLILSSLLHCCQTAQSAGVQLVK-AMPESSFRIE 1246
            ..::|:|.||.||..||  ..:|....||.||||||.||:.||.....|.::.| .:.|..|.:|
Human  1222 SPQILVPTLFNLLSRCLEPLPQEQGNMEYTKQLILSCLLNICQKLSPDGGKIPKDILDEEKFNVE 1286

  Fly  1247 LVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLHKIVEIFTFVGSTVARHDDAFSLHIIHNVVE 1311
            |:||.:|.:..|||..||||.|...||::|.:|||.|:.||||:|:.|.|.||.:|..:|:..|:
Human  1287 LIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVK 1351

  Fly  1312 SIIPILL-------LNTGHN--ELVIPVLKVFADICTDVPVHRRLPLYATLFRVLEPKEHLWQFL 1367
            .:||.|:       :....|  |:|:.::.||.|....||.|||||:...|...|..::.||..|
Human  1352 MVIPALIQSDSGDSIEVSRNVEEIVVKIISVFVDALPHVPEHRRLPILVQLVDTLGAEKFLWILL 1416

  Fly  1368 CIIFE----SQVLLEQVPQKVSTDKSRLDF----ARELTLMFEDPTVAIQTCIRLLDYLAKLPAT 1424
            .::||    ..||.....:|.:..::..:|    ..|.::..:     ||:.:.:|.||.|||..
Human  1417 ILLFEQYVTKTVLAAAYGEKDAILEADTEFWFSVCCEFSVQHQ-----IQSLMNILQYLLKLPEE 1476

  Fly  1425 KSSLSGGSGSSVLSTEQ----QLFDVRTRTFKQLRHYKYLIMDFLSGISSCNEWEKKMKRPDPNE 1485
            |......:.|...|..|    |:|:|.|.|.|||||:|:|.:.|:|.:.|.|.:.||:......|
Human  1477 KEETIPKAVSFNKSESQEEMLQVFNVETHTSKQLRHFKFLSVSFMSQLLSSNNFLKKVVESGGPE 1541

  Fly  1486 LLPYYQEFILKT-LAYVGVLNGALEAASETPSLEKFWRVLANHAHDVLDNAIGLLAPQHFISVIT 1549
            :|...:|.:|:| |.|:..:..::|..::..:: ||||.|.:.|:|:||....||..:.||.||.
Human  1542 ILKGLEERLLETVLGYISAVAQSMERNADKLTV-KFWRALLSKAYDLLDKVNALLPTETFIPVIR 1605

  Fly  1550 ELLKHDHVYVRIKVMDLLVTKLSPSSDYFQQSNAEHFGVLFAPLQEIINGILEGSSNSAQQAKLQ 1614
            .|:.:....||.|.:|||..||..:..: :::....|..|...|..|:.  .:......:||..:
Human  1606 GLVGNPLPSVRRKALDLLNNKLQQNISW-KKTIVTRFLKLVPDLLAIVQ--RKKKEGEEEQAINR 1667

  Fly  1615 QTALHALQLLALRHGRDYIEECRSLLATLTKITKRRANVPKAVVGNVVLTLVEICASLKAHALAQ 1679
            ||||:.|:||....|.:..:....:|.|..|:........|.|:|:.:|.:.|:.::|:|.|:.|
Human  1668 QTALYTLKLLCKNFGAENPDPFVPVLNTAVKLIAPERKEEKNVLGSALLCIAEVTSTLEALAIPQ 1732

  Fly  1680 LPKFAPQL-------TELLKEQVHQMASLKQGPDYVCSTLVTALHKLFKALPLFLGPYLVDIIGG 1737
            ||...|.|       :||:..:|:.:::|            .||.|:.:.||.|:.|||..|:..
Human  1733 LPSLMPSLLTTMKNTSELVSSEVYLLSAL------------AALQKVVETLPHFISPYLEGILSQ 1785

  Fly  1738 LARL--------SVQLENPQLLQDKRTQVLKQKLADVWSAVAQGVEVRILVPSCAKAFSSLLEQQ 1794
            :..|        |....|.:|...|:|             :|..:..|:|:|:..|.:.. :|:.
Human  1786 VIHLEKITSEMGSASQANIRLTSLKKT-------------LATTLAPRVLLPAIKKTYKQ-IEKN 1836

  Fly  1795 AYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNFRLQVRGLGLQRQLVSDVEASITE 1859
            ..:.:|..| .:|.:.:......:|...|..|:..||:||:||.|.....|:.  |...|..|.:
Human  1837 WKNHMGPFM-SILQEHIGVMKKEELTSHQSQLTAFFLEALDFRAQHSENDLEE--VGKTENCIID 1898

  Fly  1860 TFVTWILKLSETSFRPMYSRVHKWA-LESTSRETRLTYFLLTNRIAEALKSLFVLFASDFVEDSS 1923
            ..|..::||||.:|||::.::..|| .|...::..||::.|.:.|||.||.||.|||...|:..:
Human  1899 CLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFA 1963

  Fly  1924 RLLTEHNSIRPEFEVEEREDDVD----LLMAILNTLHHVFLYCSEDFINDHRFNVLMPPLVNQLE 1984
            ..|.:.|..:.:....:.|:|.:    ||..|||.|:.:||:.::.||:..|...||.|||:|||
Human  1964 DTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFISKERAEALMMPLVDQLE 2028

  Fly  1985 NDLVLGNESLQQVLSN----CIAQFAVA-TNDVMWKQLNSQVLLKTRTSNPEVRILAFNSCVAIA 2044
            |.|. |.|..|:.::.    |||||:|| .:|.:||.||.|:|||||.|:|:||..|..:.:|:|
Human  2029 NRLG-GEEKFQERVTKHLIPCIAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALA 2092

  Fly  2045 RKLGESYAALLPETVPFIAELLEDEHQRVEKNTRTGVQELETILGESVQKY 2095
            .||.|:|..||||::||:|||:|||.:.||...:..:|:|||:|||.:|.|
Human  2093 EKLKENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETVLGEPLQSY 2143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..350	CDD:289183	25/125 (20%)
l(2)k09022	NP_609079.2	BP28CT	1818..1966	CDD:214987	51/152 (34%)
HEATR1	NP_060542.4	U3snoRNP10	238..354	CDD:289183	24/115 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191		4/20 (20%)
		BP28CT	1857..2010	CDD:214987	51/154 (33%)
		HEAT	2106..2142		17/35 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153171
Domainoid	1	1.000	314	1.000	Domainoid score	I1294
eggNOG	1	0.900	-	-		E1_KOG1837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34562
Inparanoid	1	1.050	713	1.000	Inparanoid score	I646
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55386
OrthoDB	1	1.010	-	-		D50761at33208
OrthoFinder	1	1.000	-	-		FOG0004191
OrthoInspector	1	1.000	-	-		oto91211
orthoMCL	1	0.900	-	-		OOG6_102005
Panther	1	1.100	-	-	LDO	PTHR13457
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770