DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k09022 and Heatr1

DIOPT Version :9

Sequence 1:	NP_609079.2	Gene:	l(2)k09022 / 33960	FlyBaseID:	FBgn0086451	Length:	2096	Species:	Drosophila melanogaster
Sequence 2:	NP_001101888.1	Gene:	Heatr1 / 361262	RGDID:	1564769	Length:	2143	Species:	Rattus norvegicus

Alignment Length:	2284	Identity:	656/2284 - (28%)
Similarity:	1077/2284 - (47%)	Gaps:	334/2284 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQ 67
            |:||||||:||.||:..:|...|..||:|||||||||.||.:.:.||.|||:||...:|||::|:
  Rat     2 TSLAQQLQRLALPQTDSSLLSRREVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPAFEQFE 66

  Fly    68 LTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEV 132
            ..||.:...||||||:...:||.||..|:.||..||||.||:||....|||:.||.:|.||...:
  Rat    67 APLFSQLAKTLERSVQTKAVNKQLDENISLFLLHLSPYFLLKPAQKCLEWLIHRFHIHLYNPDSL 131

  Fly   133 MALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQST 197
            :|.:||||||.:||::::.:::.:....|:||.|:::.|||||:..::.....:..|:.|||...
  Rat   132 IACVLPYHETRVFVRVIQLLKIGNPKNKWFWLFPVKQSGVPLARGTLVTHCYKDLGFMDFICSLV 196

  Fly   198 QKAVK---ELGPRAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMAAA 259
            .::||   |....:.||:..:.|||:.:|.||..|:.|.|..:..:...:.:||.|...|:.||.
  Rat   197 TRSVKAFAECPGSSAQLRVLLAFYASTIVSALVAAENLSDNVVAKLFPYIQKGLKSSLADYRAAT 261

  Fly   260 YVIVAQLVSRTKLKSKVCNA----LLERVANCPFERLHSESLLLLVCIYGKQQAALPHFKPETI- 319
            |:|:.|:..:..::....|:    |::.:...|.:  ..:.|..|:.:..:|       ||||:
  Rat   262 YMIICQISVKVTMEDTFVNSLASQLIKTLTKVPSQ--VKDGLGCLIILLQRQ-------KPETLG 317

  Fly   320 ----LNLVGKKWLISTLSSLAKGNIAIQSICMPLMTGAVAAIRDDDASSNS-------CKLFLDN 373
                .:|.|...||..|..::: |..:..:...::...||::....|...:       .|..|:.
  Rat   318 KKPFPHLCGVPDLIGLLHGISE-NYDVSPLLRYMLPHLVASLVQHVAGEETEGIDGQIYKKHLEA 381

  Fly   374 LLSEVPMPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDTIVIDSDDEIETEKTT-FQAWY 437
            :|:::|:.......|.:...:.|:.                     ..|.:|.:..:.. ....:
  Rat   382 ILTKIPLTNNLDHLLASRLFEEYIS---------------------YSSQEETQANRVALLNEQF 425

  Fly   438 STYLEKLERRYPEAFDLSVKEALRSKSSTSNRQ---KALKLAL-GFRLNTTDEKAKHAYEKLYHY 498
            ...:..||.:||:..|:.::|.|:..:....::   :.:.|:. |.:....::........|.|.
  Rat   426 LPLVRLLESKYPKTLDVVLEEHLKEITGLKKQELFHQFISLSTSGGKYQFLEDSDTSLMLSLNHP 490

  Fly   499 SADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLGPLPL 563
            .|..||.||.. |:|:..|.|.......::|.:..|:.||:..|||..|| ......:..|....
  Rat   491 LAPVRLLAVNH-LKNIMKTSKEGIDETFIKEAILTRLGDDNVDVVSAALS-AFGSFQQHFGVEET 553

  Fly   564 AQTLCHLLYRAQSEKDEEWQPVVPLAVRHLTSALVSGSYD--TNLVLLALMPLLF--------PG 618
            ...:.:|..||:..|::.|..|:.||...|....:....|  :|.|:..|:|.:.        |.
  Rat   554 VSNILNLFQRAELSKNKGWYSVLELAANILVREEILSKNDQLSNQVVAQLLPFMVIIDNDVESPD 618

  Fly   619 EALAEHQHKALRILLGSDFVSKVPFLAELK------VSNKFSDFNVGEHRQHFLDIIASSNQELS 677
            ..:|.|       |..|...|..|.|...|      :.::.|...:|...|..:.::.|:   ||
  Rat   619 TKMAIH-------LSRSGICSLHPLLRGWKEALENVIKSRKSREIIGVGNQKMVQLLGSN---LS 673

  Fly   678 SQER-ALLQSVED----HGGELYIQKASQLTHLLL-----------------------LLTAYAK 714
            |.:| ::|:.|||    ...|.|..|.....|:::                       ||....|
  Rat   674 SGDRSSMLKLVEDLVCAGEKESYTVKQKVAFHVIVSVLVSCCSSLRETCFPFAIKVFSLLQKKIK 738

  Fly   715 R--------ELQPRESLHMLEKIGL-------YSRRLQFRVVNGSQN--TQNCAPLQLYVDFLLT 762
            :        |:.....|.::...||       |.::|     :|:|.  |::...|...:...:.
  Rat   739 KLKSIITAVEVPSEWHLELMLNRGLPEELWVHYVQQL-----HGAQRIATEDSVLLVFSLKSFIF 798

  Fly   763 LVKNTKWTALASTPWN--QMTDELR--LCL------RLLEIICAQVFSEKADQPERQEWTRALQQ 817
            .:|..|.....:..||  ::.::.|  |||      .|||:..|..|             |.|
  Rat   799 ALKAPKSFPTGAMWWNPERLDEDSRHYLCLLIGLFEMLLEVSGAMHF-------------RVL-- 848

  Fly   818 SLQLILP-EAQDRLEVLSNFYVFERLPELWPRDSDY---------AVFRLQGFIILEAVLSNPKS 872
             ::||:. ..||.|::...|.:      ||...|..         :..:.|...|..|:||:..:
  Rat   849 -MRLIVKVHLQDVLQLFKFFCI------LWTYGSSLSNPLSCTVKSELQTQALYIGSAMLSSQST 906

  Fly   873 QIDCGLVH-----VLRVANACGSPLQTLRVQAINILQLISNRKLVSHVEQLVRSLLQRKSELSMD 932
            |....|.|     |:.:....|||::.:|..|:..||.:|.  :.|..:.::..|:.:..|::.|
  Rat   907 QCKQNLAHPASPVVMSLLLNLGSPVKEVRRAAVQCLQALSG--VASKFQLVIDHLVPKAEEITSD 969

  Fly   933 HEQYALILYTIL------EPEKATAKERLVLSKLKRSVLALASDPKQSPICTA----SLLAALKH 987
            .......|.|:.      |.:|:..|    ||:..||:|....|      |.:    .|:..|:.
  Rat   970 ATYVVQDLATLFGELQNEEKQKSHHK----LSETLRSLLHCVYD------CPSYIAKDLMKVLQD 1024

  Fly   988 VNDENFLNELLPLGLDSLKTITAGEDNQNIKQLPWPHSEIYKSVIERFEGR---------VALNV 1043
            ||.|..|.:|||:                ::||           :|:.|..         :.|::
  Rat  1025 VNSEVVLAQLLPM----------------VEQL-----------LEKVEKEPTAVLKDEAIVLHL 1062

  Fly  1044 LLRK--DLAWKLFEDSFAQYDTYVQ---LEQKLQP-LPCV---LLNSLTPETFEQM-HAKHKIAL 1098
            .|.|  :.:..|.:......|.:::   ..::|.| :|.|   .|..:|...|..: ..|.:..|
  Rat  1063 TLGKYNECSASLLQKDSKSLDLFIKAMHTTKELHPGMPTVQITALEKITKPFFAAVSDGKVQQKL 1127

  Fly  1099 IKLIVESATNSDND-------SIFLASHRLLKRCRLDCQP--LVPILLEMANTKVEKKQPVKRRS 1154
            :.::.:...|..|.       |:|.......::.|::.:|  ....|..:..|:.:|.|..|.:.
  Rat  1128 LCVLFDLLVNCKNSHCVQTVGSVFKGISVDAEQIRIELEPRDKAKSLGTIQQTRRQKMQQKKSQD 1192

  Fly  1155 VQATQLDLTSPYWKQGMTLLELLEHKKQLVGAELLIPPLFELLQACL--TMEEHSAAEYPKQLIL 1217
            |:|.| ::..|||::...:||||:|||:|...::|||.||.||..||  ...|....||.|||||
  Rat  1193 VEAVQ-EVEGPYWQRVTLILELLQHKKKLKCPQILIPTLFNLLSRCLEPLSSEQGNMEYTKQLIL 1256

  Fly  1218 SSLLHCCQTAQSAGVQLVK-AMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLH 1281
            |.||:.||.....|.::.| .:.|..|.:||:||.:|.:..|||..||||.|...||::|.:|||
  Rat  1257 SCLLNICQKLSPDGGKIPKDVVDEEKFNVELIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVLH 1321

  Fly  1282 KIVEIFTFVGSTVARHDDAFSLHIIHNVVESIIPILL---------LNTGHNELVIPVLKVFADI 1337
            .|:.||||:|:.|.|.|||:|..:|...|:.:||.|:         :.....|:|:.::.||.|.
  Rat  1322 NIMSIFTFMGANVMRLDDAYSFQVISKTVKMVIPALIQSDNGDSIEVTRNVEEIVVKIIGVFVDA 1386

  Fly  1338 CTDVPVHRRLPLYATLFRVLEPKEHLWQFLCIIFE----SQVLLEQVPQKVSTDKSRLDF----A 1394
            ...||.|||||:...|...|..::.||..|.::||    ..||:....:|.:..::..:|    .
  Rat  1387 LPHVPEHRRLPILVQLINTLGAEKFLWILLALLFEQYVTKTVLVAAYGEKDAILEADTEFWISVC 1451

  Fly  1395 RELTLMFEDPTVAIQTCIRLLDYLAKLPATKSSLSGGSGSSVLSTEQQL---FDVRTRTFKQLRH 1456
            .|.::..:     :|:.:.:|.||.|||..|...:..:.|:.:..:.::   |.|.|.|.|||||
  Rat  1452 CEFSVQHQ-----VQSLMHILQYLEKLPEEKEEATSKAVSAKIEVQDEMLPVFKVDTHTSKQLRH 1511

  Fly  1457 YKYLIMDFLSGISSCNEWEKK-MKRPDPNELLPYYQEFILKTLAYVGVLNGALEAASETPSLEKF 1520
            :|||.:.|::.:.:.|.:.|| ::...|..|....|..:...|.|:..:..::|..::..: .||
  Rat  1512 FKYLSVSFMAQLLASNHFLKKVVESGGPKSLHGLEQSLLETVLGYINTVAQSMEKNADKLT-GKF 1575

  Fly  1521 WRVLANHAHDVLDNAIGLLAPQHFISVITELLKHDHVYVRIKVMDLLVTKLSPSSDYFQQSNAEH 1585
            ||.|.:.|:|:||....||..:.|||||..|:.:....||.|.:|||..||..|:  |.:....|
  Rat  1576 WRALLSKAYDMLDKVNALLPTETFISVIKGLVGNPLPSVRRKALDLLNNKLQHST--FWKKKMVH 1638

  Fly  1586 FGVLFAPLQEIINGILEGSSNSA--QQAKLQQTALHALQLLALRHGRDYIEECRSLLATLTKITK 1648
               .|..|..::..|::.....|  :||..:||||:.|:||....|....|....:|:|..|:..
  Rat  1639 ---RFLKLVPVLLAIVQHKKKEAEDEQAINRQTALYTLKLLCKNFGAQNREPFIPVLSTAVKLIA 1700

  Fly  1649 RRANVPKAVVGNVVLTLVEICASLKAHALAQLPKFAPQL-------TELLKEQVHQMASLKQGPD 1706
            ......|.|:|:.:|.:.|:.::|:|.|:.|||...|.|       :||::.:|..:::|
  Rat  1701 PEKKEEKNVLGSALLCIAEVTSTLEALAIPQLPSLMPSLLTAIKSTSELVRSEVCLLSAL----- 1760

  Fly  1707 YVCSTLVTALHKLFKALPLFLGPYLVDIIGGLARLSVQLENPQLLQDKRTQVLKQKLADVWSAVA 1771
                   |||||:.:.||.|:.|||    .||....:.||.........:|. ..:|..:...:|
  Rat  1761 -------TALHKVVETLPHFISPYL----EGLLTQVIHLEKITSEMGSASQA-NIRLTSLKKTLA 1813

  Fly  1772 QGVEVRILVPSCAKAFSSLLEQQAYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNF 1836
            .|:..|:|:|:.:|.|..:  |:.:..|......:|.:.:......:|...|..|:..||:||:|
  Rat  1814 TGLSPRVLLPAISKTFKQI--QKNWKNLMGPFMSILQEHIGVMKKEELLSHQSQLTTFFLEALDF 1876

  Fly  1837 RLQVRGLGLQRQLVSDVEASITETFVTWILKLSETSFRPMYSRVHKWA-LESTSRETRLTYFLLT 1900
            |.|.....|:.  |...|:.|.:..|..::||||.:|||::.::..|| .|...::..||::.|.
  Rat  1877 RAQHSEDDLEE--VGKTESWIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLA 1939

  Fly  1901 NRIAEALKSLFVLFASDFVEDSSRLLTEHNSIRPEFEVEEREDDVD----LLMAILNTLHHVFLY 1961
            :.|||.||.||.|||...|:..:..|.:.|..:.:....:.|.|.:    ||..|||.|:.:||:
  Rat  1940 DCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSEHDPEKCCLLLQFILNCLYKIFLF 2004

  Fly  1962 CSEDFINDHRFNVLMPPLVNQLENDLVLGNESLQQVLSN----CIAQFAVA-TNDVMWKQLNSQV 2021
            .:::|::..|...||.|||:||||.|. |.:..|:.::.    |||||:|| .:|.|||.||.|:
  Rat  2005 DTQNFMSKERAEALMMPLVDQLENRLG-GEDRFQERVTKHLVPCIAQFSVAMADDSMWKPLNYQI 2068

  Fly  2022 LLKTRTSNPEVRILAFNSCVAIARKLGESYAALLPETVPFIAELLEDEHQRVEKNTRTGVQELET 2086
            |||||.|:|:||..|..:.:|:|.||.|:|..||||::||:|||:|||.:.||...:|.:|:||.
  Rat  2069 LLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQTTIQQLEA 2133

  Fly  2087 ILGESVQKY 2095
            :|||.:|.|
  Rat  2134 VLGEPLQSY 2142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..350	CDD:289183	25/122 (20%)
l(2)k09022	NP_609079.2	BP28CT	1818..1966	CDD:214987	51/152 (34%)
Heatr1	NP_001101888.1	U3snoRNP10	238..354	CDD:289183	25/125 (20%)
		HEAT repeat	517..547	CDD:293787	9/30 (30%)
		HEAT repeat	1643..1678	CDD:293787	12/34 (35%)
		HEAT repeat	1687..1723	CDD:293787	8/35 (23%)
		HEAT repeat	1734..1762	CDD:293787	6/39 (15%)
		BP28CT	1856..2009	CDD:214987	51/154 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346782
Domainoid	1	1.000	379	1.000	Domainoid score	I811
eggNOG	1	0.900	-	-		E1_KOG1837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34562
Inparanoid	1	1.050	776	1.000	Inparanoid score	I503
OMA	1	1.010	-	-		QHG55386
OrthoDB	1	1.010	-	-		D50761at33208
OrthoFinder	1	1.000	-	-		FOG0004191
OrthoInspector	1	1.000	-	-		oto98298
orthoMCL	1	0.900	-	-		OOG6_102005
Panther	1	1.100	-	-	LDO	PTHR13457
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4007
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810