DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k09022 and heatr1

DIOPT Version :9

Sequence 1:	NP_609079.2	Gene:	l(2)k09022 / 33960	FlyBaseID:	FBgn0086451	Length:	2096	Species:	Drosophila melanogaster
Sequence 2:	XP_009304764.1	Gene:	heatr1 / 334446	ZFINID:	ZDB-GENE-030131-6378	Length:	2160	Species:	Danio rerio

Alignment Length:	2295	Identity:	662/2295 - (28%)
Similarity:	1067/2295 - (46%)	Gaps:	339/2295 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQ 67
            |:||.||::||.||:..:|...:...|:|||||:||:.||.:.:.:|.|||:||...:.||.|||
Zfish     2 TSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQ 66

  Fly    68 LTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEV 132
            .|||.:.:|||||||:..|:||.||.:|:.||..||||.||:||....||||.||.:|.||:..:
Zfish    67 ETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSL 131

  Fly   133 MALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQST 197
            :|.:||||||.:||::::..::......|:||..:|:||||||:..::.....:..|:.|:|...
Zfish   132 IACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMV 196

  Fly   198 QKAVKELGP-----RAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMA 257
            ..:||....     ...||:...:|||:.:|.||...:.:.:..|..:|..:..||.|:..|:.|
Zfish   197 TNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTA 261

  Fly   258 AAYVIVAQLVSRTKLKSKVCNAL---LER-VANCPFERLHSESLLLLVCIYGKQQAALPHFKPET 318
            |.|:||.|:..:..:::::.::|   |.| :...|  :|..|.|..::.:...|:.
Zfish   262 ATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTP--QLIREGLSCIIILLQNQKK--------- 315

  Fly   319 ILNLVGKK---------WLISTLSSLAKGN--IAIQSICMPLMTGAVAAIRDD---DASSNSCKL 369
              .::|:|         .|:|||.|::..:  ..:.|..:|.:..:|....|:   :..|:|..|
Zfish   316 --GVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGL 378

  Fly   370 FLDNLLSEVPMPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDTIVIDSDDEIETEKTTFQ 434
             |.::...:.:............|:.||....:.|                  .|.|.......|
Zfish   379 -LQSVFQNLQLSSNLENTAAKLLLEEYVVCGNELP------------------SDGISALNQRIQ 424

  Fly   435 AWYSTYLEKLERRYPEAFDLSVKEALRSKSSTSNRQK-----ALKLALGFRLNTTDEKAKHAYEK 494
            .....:    |.|||.|.|::::..:::.||.:.:..     :|.|:.| :.....|........
Zfish   425 PTVRLF----ESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCG-KYQILPESETSLMLS 484

  Fly   495 LYHYSADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLG 559
            |.|.....|..||..|.:.||...:.......|::.|.:||.|||..||.:.|    :.|...:|
Zfish   485 LNHPLPSVRNMAVDYLKEILNSEHQNSFDEAFLKDALLERIKDDSPEVVLSAL----KALQHHMG 545

  Fly   560 PLPLAQT---LCHLLYRAQSEKDEEWQPVVPLAVRHLTS-ALVSGSYDTN-LVLLALMPLLFPGE 619
            .:.:..|   |..||:|.:...|  |.||:..|||.|.. .::.|:.|.. .:...|:|.|....
Zfish   546 LMDVEDTVSSLISLLHRIKPSAD--WCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTR 608

  Fly   620 ALAE----------------HQH-------KALRILLG----SDFVSKVPFLAELKVSNKFSDFN 657
            |..|                .||       |.|:.:|.    ||.:.....:....:....::.:
Zfish   609 AAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMD 673

  Fly   658 VGEHR---QHFLDIIASSNQELSSQER--------ALLQSVEDHGGELYIQKASQLTHLL--LLL 709
            ....|   ::..||:  |.|..|.::|        |||||::......::..|..:..||  |||
Zfish   674 HATKRNTLENVCDIL--SRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLL 736

  Fly   710 TAYAKRELQPR--------ESLHMLEKIGLYSRRLQFRVVNGSQNTQNCAPLQLYVDFLLTL--- 763
            .||.   :||.        |.|.:...:|.:.:::...:  .::..|....|.|...|:.||
Zfish   737 QAYT---IQPEQVSDQPADECLPVCVALGEFLQKISCGL--SAEQEQGLLLLSLLRLFITTLKCP 796

  Fly   764 ---VKNTKWTALASTPWNQMTDELRLC--LRLLEIICAQVFSEKADQPERQEWTRALQQSLQLIL 823
               .|...|       ||....|...|  ||||..:...|.|..:..|....:...:|..||:.|
Zfish   797 DSTFKGEPW-------WNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHL 854

  Fly   824 PEAQDRLEVLSNFYVFERLPELWPRDSDY---------AVFRLQGFIILEAVLSNPKSQIDCGLV 879
            .|.         ..:|:.|..||..:|:.         |:.:.|...:.:|.||:..       |
Zfish   855 NEP---------MVLFKFLSLLWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQP-------V 903

  Fly   880 HVLRVANACGSPLQ------------TLRVQAINILQLISNRKLVSH-VEQLVRSLLQRKSELSM 931
            ..|.:..:..||:.            .:|..||.:||.:|.  |||. ...||..||:...|:..
Zfish   904 KTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSG--LVSSPYHPLVEKLLKSSEEIIA 966

  Fly   932 DHEQYALILYTILEPEKATAKERLVLSKLKRSVLALASDPKQSPIC----TASLLAALKHVNDEN 992
            |.......|....|...:...:...|:.:::.:..|     |||.|    :.:||.||:.|:.|.
Zfish   967 DSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCL-----QSPFCPSYTSKTLLRALQDVHGEP 1026

  Fly   993 FLNELLPLGLDSLKTITAGEDNQNIKQLPWPHSEIYKSVIERFEGRVALNVLLRK--DLAWKLFE 1055
            .|:.||| .::.|....|.:   :...||              :..:.|.:||.|  :::..|..
Zfish  1027 VLSVLLP-AVERLLEQCAPD---SCTFLP--------------DEALLLQLLLSKFSEMSAPLLV 1073

  Fly  1056 DSFAQYDTYVQ-LEQKLQPLPCV------LLNSLTPETF-----EQMHAKHKIALIKLIVESATN 1108
            ......:.::: |....:|.|.:      .|..:|...|     |::..|....|..|:|.:.:.
Zfish  1074 KDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSP 1138

  Fly  1109 SDNDSIFLASHRLLKRCRLDCQPLVPILLEMANTKVEKKQPVKRRSVQAT-----QLDLTSPYWK 1168
            :...||......:...|.|....|:|...:.....|::.:..|.|..|.|     :..:.|  |.
Zfish  1139 ACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVS--WP 1201

  Fly  1169 QGMTLLELLEHKKQLVGAELLIPPLFELLQACL--TMEEHSAAEYPKQLILSSLLHCCQTAQSAG 1231
            :...:||||:|||:|..|:.|:|.||.||..||  ...|....||.|||||..||:.||.....|
Zfish  1202 RVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEG 1266

  Fly  1232 VQLVK-AMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLHKIVEIFTFVGSTVA 1295
            ..:.| .:.|..|.:|||||.:|.:..|||..||||.|...||::|::|||.|:.||||:|:.:.
Zfish  1267 GPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIM 1331

  Fly  1296 RHDDAFSLHIIHNVVESIIPILL--------LNTGHNELVI-PVLKVFADICTDVPVHRRLPLYA 1351
            |.||.:|..:|:..|:::||.|:        .:.||.|.|: .::.||.|....||.|||||:.:
Zfish  1332 RLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILS 1396

  Fly  1352 TLFRVLEPKEHLWQFLCIIFESQVLLEQVPQKVSTDKSRLDFARELTLMFEDPTVAIQTC----- 1411
            .|...|.|...||..:.::|:         |.|:...:....|.:..::..|....|..|
Zfish  1397 QLMSTLGPSRFLWVLMLLLFK---------QHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEV 1452

  Fly  1412 -------IRLLDYLAKLPATKSSL---SGGSGSSVLSTEQQ----LFDVRTRTFKQLRHYKYLIM 1462
                   |::|.||..||..:...   ....|.|.:..::.    :|.|.|.:.|.|||:|::.:
Zfish  1453 KEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISI 1517

  Fly  1463 DFLSGISSCNEWEKKMKRPD---PNELLPYYQEFILKTLAYVGVLNGALEAASETPSLEKFWRVL 1524
            .|::.:.:.:.:..|:...:   .:.|....|:.:::.|.|:..:...:|..::.|: .||||.|
Zfish  1518 SFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPT-AKFWRAL 1581

  Fly  1525 ANHAHDVLDNAIGLLAPQHFISVITELLKHDHVYVRIKVMDLLVTKLSPSSDYFQQSNAEHFGVL 1589
            .:.::|.||....||....||:|:..|:.:....||.|.|:||..||...:.:.::.
Zfish  1582 LSKSYDTLDKVNALLPMDTFITVMRGLMGNQLASVRRKAMELLNNKLQQRTKWLKEQ-------- 1638

  Fly  1590 FAPLQEIINGILEGSSNSAQQAKLQ---------QTALHALQLLALRHGRDYIEECRSLLATLTK 1645
            ...|.|:|..:|.....|.:|...|         ||||::|:||....|.|:.||...:|....:
Zfish  1639 ITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVE 1703

  Fly  1646 ITKRRANVPKAVVGNVVLTLVEICASLKAHALAQLPKFAPQLTELLKEQVHQMASLKQGPDYVCS 1710
            :...: :..|.|:|:.:|.:.|:.::|||.|:.||.:..|.:.:.|||:    ..|.....|:.|
Zfish  1704 LVADK-DEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKER----KDLLNNEIYLLS 1763

  Fly  1711 TLVTALHKLFKALPLFLGPYLVDIIGGLARLSVQLENPQLLQDKRTQV--LKQKLADVWSAVAQG 1773
            . ||||.:..:.||.|:.|||:|.|..:.||:       ||..:.|..  |..:||.:.|.:|..
Zfish  1764 A-VTALQRASETLPHFISPYLLDTILQVTRLT-------LLARRLTSCPQLSVRLASLSSTLATK 1820

  Fly  1774 VEVRILVPSCAKAFSSLLEQQAYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNFRL 1838
            :..|:|:|:..|.:.|:::.| .:.|..|| .:|.:.:.|....||...|..|:..||.||:||.
Zfish  1821 LPPRVLIPTITKCYCSMVDAQ-QNRLSPLM-NILKEHISHMDKDQLNNHQSELTSFFLSALDFRA 1883

  Fly  1839 QVRGLGLQRQLVSDVEASITETFVTWILKLSETSFRPMYSRVHKWA-LESTSRETRLTYFLLTNR 1902
            |.....|::  .:::|..:.:..:..|:||||.:|||::.::..|: ::..|::..||::.|.:|
Zfish  1884 QHCQGDLKK--TAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADR 1946

  Fly  1903 IAEALKSLFVLFASDFVEDSSRLLTEHNSIRPE---FEVE-EREDDVD------------LLMAI 1951
            ||:.||.||||||...|:..|.||.:.|:...:   |:.| |.:||.|            ||..:
Zfish  1947 IADKLKGLFVLFAGQLVKPFSDLLHQLNTSHTDKAFFDSEDESDDDSDEEADDNVTKSSLLLQYV 2011

  Fly  1952 LNTLHHVFLYCSEDFINDHRFNVLMPPLVNQLENDLVLGNES-----LQQVLSNCIAQFAVA-TN 2010
            |:.||.:|||.::.|::..|.:.|:.|||:||||  :||.|.     :...|..|||||||| .:
Zfish  2012 LDCLHKIFLYDTQHFLSKERADALLCPLVDQLEN--ILGGEETYKSRITTHLVPCIAQFAVAMRD 2074

  Fly  2011 DVMWKQLNSQVLLKTRTSNPEVRILAFNSCVAIARKLGESYAALLPETVPFIAELLEDEHQRVEK 2075
            |..||.||.|:|||||.|:|:||..|....:.:|.||.|:|..|||||:||:|||:|||.:.||.
Zfish  2075 DSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEDECEEVEH 2139

  Fly  2076 NTRTGVQELETILGESVQKY 2095
            ..:..:||:||||||.:|.|
Zfish  2140 QVQKVIQEMETILGEPLQSY 2159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..350	CDD:289183	29/128 (23%)
l(2)k09022	NP_609079.2	BP28CT	1818..1966	CDD:214987	56/164 (34%)
heatr1	XP_009304764.1	U3snoRNP10	240..356	CDD:289183	29/128 (23%)
		HEAT repeat	476..506	CDD:293787	8/29 (28%)
		HEAT repeat	515..542	CDD:293787	11/30 (37%)
		HEAT repeat	553..580	CDD:293787	11/28 (39%)
		BP28CT	1861..2026	CDD:214987	56/166 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588232
Domainoid	1	1.000	319	1.000	Domainoid score	I1224
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34562
Inparanoid	1	1.050	713	1.000	Inparanoid score	I626
OMA	1	1.010	-	-		QHG55386
OrthoDB	1	1.010	-	-		D50761at33208
OrthoFinder	1	1.000	-	-		FOG0004191
OrthoInspector	1	1.000	-	-		otm25028
orthoMCL	1	0.900	-	-		OOG6_102005
Panther	1	1.100	-	-	LDO	PTHR13457
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1613
SonicParanoid	1	1.000	-	-		X4007
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940