DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)k09022 and heatr1

DIOPT Version :10

Sequence 1:NP_609079.2 Gene:l(2)k09022 / 33960 FlyBaseID:FBgn0086451 Length:2096 Species:Drosophila melanogaster
Sequence 2:XP_073773536.1 Gene:heatr1 / 334446 ZFINID:ZDB-GENE-030131-6378 Length:2192 Species:Danio rerio


Alignment Length:2277 Identity:650/2277 - (28%)
Similarity:1052/2277 - (46%) Gaps:346/2277 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQ 67
            |:||.||::||.||:..:|...:...|:|||||:||:.||.:.:.:|.|||:||...:.||.|||
Zfish     2 TSLAHQLKRLALPQNDSSLLGRKEVVSVLFDPKDAASMDRSTFHALGCTGLEELMGIDAAFSEFQ 66

  Fly    68 LTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEV 132
            .|||.:.:|||||||:..|:||.||.:|:.||..||||.||:||....||||.||.:|.||:..:
Zfish    67 ETLFSQGSLTLERSVQSKEVNKKLDKSISLFLTRLSPYFLLKPALKCIEWLLHRFHIHLYNQDSL 131

  Fly   133 MALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQST 197
            :|.:||||||.:||::::..::......|:||..:|:||||||:..::.....:..|:.|:|...
Zfish   132 IACVLPYHETKVFVRVIQLFKIEDPTHKWHWLHGIQKPGVPLARGTLLTHCYKDLGFMDFVCSMV 196

  Fly   198 QKAVKELGP-----RAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMA 257
            ..:||....     ...||:...:|||:.:|.||...:.:.:..|..:|..:..||.|:..|:.|
Zfish   197 TNSVKAYSELTRDGNCPQLRVIFSFYASTIVSALDAVEKITNSIIAKLLPFVQLGLKSNLSDYTA 261

  Fly   258 AAYVIVAQLVSRTKLKSKVCNAL---LER-VANCPFERLHSESLLLLVCIYGKQQAALPHFKPET 318
            |.|:||.|:..:..:::::.::|   |.| :...|  :|..|.|..::.:...|:.         
Zfish   262 ATYMIVCQMAVKVVMEAQLVDSLSVQLSRSLGRTP--QLIREGLSCIIILLQNQKK--------- 315

  Fly   319 ILNLVGKK---------WLISTLSSLAKGN--IAIQSICMPLMTGAVAAIRDD---DASSNSCKL 369
              .::|:|         .|:|||.|::..:  ..:.|..:|.:..:|....|:   :..|:|..|
Zfish   316 --GVIGQKTYGYLCAVPTLVSTLQSISTVHDISPLLSYLLPHLIHSVMTQNDEQQNEGLSDSTGL 378

  Fly   370 FLDNLLSEVPMPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDTIVIDSDDEIETEKTTFQ 434
             |.::...:.:............|:.||....:.|                  .|.|.......|
Zfish   379 -LQSVFQNLQLSSNLENTAAKLLLEEYVVCGKELP------------------SDGISALNQRIQ 424

  Fly   435 AWYSTYLEKLERRYPEAFDLSVKEALRSKSSTSNRQK-----ALKLALGFRLNTTDEKAKHAYEK 494
            .....:    |.|||.|.|::::..:::.||.:.:..     :|.|:.| :.....|........
Zfish   425 PTVRLF----ESRYPCALDMALENHVKNVSSDNEKNLLHQFISLTLSCG-KYQILPESETSLMLS 484

  Fly   495 LYHYSADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLG 559
            |.|.....|..||..|.:.|| ::........|::.|.:||.|||..||.:.|    :.|...:|
Zfish   485 LNHPLPSVRNMAVDYLKEILN-SEHNSFDEAFLKDALLERIKDDSPEVVLSAL----KALQHHMG 544

  Fly   560 PLPLAQT---LCHLLYRAQSEKDEEWQPVVPLAVRHLTS-ALVSGSYDTN-LVLLALMPLLFPGE 619
            .:.:..|   |..||:|.:...|  |.||:..|||.|.. .::.|:.|.. .:...|:|.|....
Zfish   545 LMDVEDTVSSLISLLHRIKPSAD--WCPVLKEAVRVLDDPRIIEGNPDLKAYISWELLPFLVMTR 607

  Fly   620 ALAE----------------HQH-------KALRILLG----SDFVSKVPFLAELKVSNKFSDFN 657
            |..|                .||       |.|:.:|.    ||.:.....:....:....::.:
Zfish   608 AAPECVELQMTSAITETTLISQHPLTQGWAKVLKAVLAKTSESDLLGVANEMLTTTLIKNLANMD 672

  Fly   658 VGEHR---QHFLDIIASSNQELSSQER--------ALLQSVEDHGGELYIQKASQLTHLL--LLL 709
            ....|   ::..||:  |.|..|.::|        |||||::......::..|..:..||  |||
Zfish   673 HATKRNTLENVCDIL--SRQGSSVRDRAAFVVFSSALLQSLQSMTESQHLHTAQSVYKLLEPLLL 735

  Fly   710 TAYAKRELQPR--------ESLHMLEKIGLYSRRLQFRVVNGSQNTQNCAPLQLYVDFLLTL--- 763
            .||.   :||.        |.|.:...:|.:.:::...:  .::..|....|.|...|:.||   
Zfish   736 QAYT---IQPEQVSDQPADECLPVCVALGEFLQKISCGL--SAEQEQGLLLLSLLRLFITTLKCP 795

  Fly   764 ---VKNTKWTALASTPWNQMTDELRLC--LRLLEIICAQVFSEKADQPERQEWTRALQQSLQLIL 823
               .|...|       ||....|...|  ||||..:...|.|..:..|....:...:|..||:.|
Zfish   796 DSTFKGEPW-------WNPEKMETTTCCYLRLLCRLFDVVISGASQGPLAPCFRSLMQPLLQVHL 853

  Fly   824 PEAQDRLEVLSNFYVFERLPELWPRDSDY---------AVFRLQGFIILEAVLSNPKSQIDCGLV 879
            .|.         ..:|:.|..||..:|:.         |:.:.|...:.:|.||:..       |
Zfish   854 NEP---------MVLFKFLSLLWGYNSNLGDQLDCRVSAILQTQALYVGKAFLSSQP-------V 902

  Fly   880 HVLRVANACGSPLQ------------TLRVQAINILQLISNRKLVSH-VEQLVRSLLQRKSELSM 931
            ..|.:..:..||:.            .:|..||.:||.:|.  |||. ...||..||:...|:..
Zfish   903 KTLNLLASDSSPVVPSLLVCVCSGVCEVRRAAIAVLQCLSG--LVSSPYHPLVEKLLKSSEEIIA 965

  Fly   932 DHEQYALILYTILEPEKATAKERLVLSKLKRSVLALASDPKQSPIC----TASLLAALKHVNDEN 992
            |.......|....|...:...:...|:.:::.:..|     |||.|    :.:||.||:.|:.|.
Zfish   966 DSSYLTQALSKFYEEAVSRKDKNKKLASVEQLLQCL-----QSPFCPSYTSKTLLRALQDVHGEP 1025

  Fly   993 FLNELLPLGLDSLKTITAGEDNQNIKQLPWPHSEIYKSVIERFEGRVALNVLLRK--DLAWKLFE 1055
            .|:.||| .::.|....|.:   :...||              :..:.|.:||.|  :::..|..
Zfish  1026 VLSVLLP-AVERLLEQCAPD---SCTFLP--------------DEALLLQLLLSKFNEMSAPLLV 1072

  Fly  1056 DSFAQYDTYVQ-LEQKLQPLPCV------LLNSLTPETF-----EQMHAKHKIALIKLIVESATN 1108
            ......:.::: |....:|.|.:      .|..:|...|     |::..|....|..|:|.:.:.
Zfish  1073 KDPRCLEVFIRALHTSARPYPTIPSFQITALEQITKPFFTAIGDEKIQQKILSILFDLLVGNKSP 1137

  Fly  1109 SDNDSIFLASHRLLKRCRLDCQPLVPILLEMANTKVEKKQPVKRRSVQAT-----QLDLTSPYWK 1168
            :...||......:...|.|....|:|...:.....|::.:..|.|..|.|     :..:.|  |.
Zfish  1138 ACAQSINSVFKTIAVDCELVANELIPADKQRVTATVQQTRRSKMRKTQDTSGAVPEESVVS--WP 1200

  Fly  1169 QGMTLLELLEHKKQLVGAELLIPPLFELLQACL--TMEEHSAAEYPKQLILSSLLHCCQTAQSAG 1231
            :...:||||:|||:|..|:.|:|.||.||..||  ...|....||.|||||..||:.||.....|
Zfish  1201 RVTLILELLQHKKKLKRAQYLVPALFNLLSRCLEPAAAEQENIEYTKQLILICLLNVCQKLSPEG 1265

  Fly  1232 VQLVK-AMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAGMYPQQVLHKIVEIFTFVGSTVA 1295
            ..:.| .:.|..|.:|||||.:|.:..|||..||||.|...||::|::|||.|:.||||:|:.:.
Zfish  1266 GPISKDVLEEDKFNMELVVQCVRVSEMPQTHHHALLLLGALAGIFPEKVLHNIMPIFTFMGANIM 1330

  Fly  1296 RHDDAFSLHIIHNVVESIIPILL--------LNTGHNELVI-PVLKVFADICTDVPVHRRLPLYA 1351
            |.||.:|..:|:..|:::||.|:        .:.||.|.|: .::.||.|....||.|||||:.:
Zfish  1331 RLDDTYSFQVINKTVQAVIPALIKAHEGGSSQSEGHMETVVAQIIHVFVDALPHVPEHRRLPILS 1395

  Fly  1352 TLFRVLEPKEHLWQFLCIIFESQVLLEQVPQKVSTDKSRLDFARELTLMFEDPTVAIQTC----- 1411
            .|...|.|...||..:.::|:         |.|:...:....|.:..::..|....|..|     
Zfish  1396 QLMSTLGPSRFLWVLMLLLFK---------QHVTQTSAGATGAEKEAVVERDQDFWILVCCEFEV 1451

  Fly  1412 -------IRLLDYLAKLPATKSSL---SGGSGSSVLSTEQQ----LFDVRTRTFKQLRHYKYLIM 1462
                   |::|.||..||..:...   ....|.|.:..::.    :|.|.|.:.|.|||:|::.:
Zfish  1452 KEQLTSLIKILQYLMTLPQDREEAPEKKKPRGRSAVKKDETVSDLIFSVETHSGKDLRHFKFISI 1516

  Fly  1463 DFLSGISSCNEWEKKMKRPD---PNELLPYYQEFILKTLAYVGVLNGALEAASETPSLEKFWRVL 1524
            .|::.:.:.:.:..|:...:   .:.|....|:.:::.|.|:..:...:|..::.|: .||||.|
Zfish  1517 SFMAQLLASDGFVGKVADCEDITESTLQALQQDLLVEVLRYIQAVARCVEDNADKPT-AKFWRAL 1580

  Fly  1525 ANHAHDVLDNAIGLLAPQHFISVITELLKHDHVYVRIKVMDLLVTKLSPSSDYFQQSNAEHFGVL 1589
            .:.::|.||....||....||:|:..|:.:....||.|.|:||..||...:.:.::.        
Zfish  1581 LSKSYDTLDKVNALLPMDTFITVMRGLMGNQLASVRRKAMELLNNKLQQRTKWLKEQ-------- 1637

  Fly  1590 FAPLQEIINGILEGSSNSAQQAKLQ---------QTALHALQLLALRHGRDYIEECRSLLATLTK 1645
            ...|.|:|..:|.....|.:|...|         ||||::|:||....|.|:.||...:|....:
Zfish  1638 ITALLELIGTLLSIVGRSHRQVTAQEEEELAINRQTALYSLKLLCRNFGSDHKEEFVPVLNKAVE 1702

  Fly  1646 ITKRRANVPKAVVGNVVLTLVEICASLKAHALAQLPKFAPQLTELLKEQVHQMASLKQGPDYVCS 1710
            :...: :..|.|:|:.:|.:.|:.::|||.|:.||.:..|.:.:.|||:    ..|.....|:.|
Zfish  1703 LVADK-DEEKNVMGSALLCVAEVTSTLKALAIPQLHRLMPAVLDTLKER----KDLLNNEIYLLS 1762

  Fly  1711 TLVTALHKLFKALPLFLGPYLVDIIGGLARLSVQLENPQLLQDKRTQV--LKQKLADVWSAVAQG 1773
            . ||||.:..:.||.|:.|||:|.|..:.||:       ||..:.|..  |..:||.:.|.:|..
Zfish  1763 A-VTALQRASETLPHFISPYLLDTILQVTRLT-------LLARRLTSCPQLSVRLASLSSTLATK 1819

  Fly  1774 VEVRILVPSCAKAFSSLLEQQAYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSELFLQALNFRL 1838
            :..|:|:|:..|.:.|:::.| .:.|..|| .:|.:.:.|....||...|..|:..||.||:||.
Zfish  1820 LPPRVLIPTITKCYCSMVDAQ-QNRLSSLM-NILKEHISHMDKDQLNNHQSELTSFFLSALDFRA 1882

  Fly  1839 QVRGLGLQRQLVSDVEASITETFVTWILKLSETSFRPMYSRVHKWA-LESTSRETRLTYFLLTNR 1902
            |.....|::  .:::|..:.:..:..|:||||.:|||::.::..|: ::..|::..||::.|.:|
Zfish  1883 QHCQGDLKK--TAEIEGCVIDCLLVMIMKLSEVTFRPLFFKLFDWSKIDGASKDRLLTFYRLADR 1945

  Fly  1903 IAEALKSLFVLFASDFVEDSSRLLTEHNSIRPE---FEVE-EREDDVD------------LLMAI 1951
            ||:.||.||||||...|:..|.||.:.|:...:   |:.| |.::|.|            ||..:
Zfish  1946 IADKLKGLFVLFAGQLVKPFSDLLHQLNTSHTDKAFFDSEDESDEDSDEEADDNVTKSSLLLQYV 2010

  Fly  1952 LNTLHHVFLYCSEDFINDHRFNVLMPPLVNQLENDLVLGNES-----LQQVLSNCIAQFAVA-TN 2010
            |:.||.:|||.::.|::..|.:.|:.|||:||||  :||.|.     :...|..|||||||| .:
Zfish  2011 LDCLHKIFLYDTQHFLSKERADALLCPLVDQLEN--MLGGEETYKSRITTHLVPCIAQFAVAMRD 2073

  Fly  2011 DVMWKQLNSQVLLKTRTSNPEVRILAFNSCVAIARKLGESYAALLPETVPFIAELLEDEHQRVEK 2075
            |..||.||.|:|||||.|:|:||..|....:.:|.||.|:|..|||||:||:|||:|.      |
Zfish  2074 DSQWKVLNYQILLKTRHSSPKVRFSALVMLLELAGKLRENYMVLLPETIPFLAELMEG------K 2132

  Fly  2076 NT 2077
            ||
Zfish  2133 NT 2134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)k09022NP_609079.2 U3snoRNP10 236..353 CDD:463559 29/131 (22%)
BP28CT 1818..1966 CDD:214987 55/164 (34%)
heatr1XP_073773536.1 None

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