DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)k09022 and Heatr1

DIOPT Version :9

Sequence 1:	NP_609079.2	Gene:	l(2)k09022 / 33960	FlyBaseID:	FBgn0086451	Length:	2096	Species:	Drosophila melanogaster
Sequence 2:	NP_659084.3	Gene:	Heatr1 / 217995	MGIID:	2442524	Length:	2143	Species:	Mus musculus

Alignment Length:	2292	Identity:	666/2292 - (29%)
Similarity:	1074/2292 - (46%)	Gaps:	350/2292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAFKEFQ 67
            |:||||||:||.||:..:|...|..||:|||||||||.||.:.:.||.|||:||...:|||::|:
Mouse     2 TSLAQQLQRLALPQTDPSLLSRREVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPAFEQFE 66

  Fly    68 LTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNRSEV 132
            ..||.:....|||||:...:||.||..|:.||..||||.||:||....|||:.||.:|.||...:
Mouse    67 APLFSQLAKGLERSVQTKAVNKQLDENISSFLLHLSPYFLLKPAQKCLEWLIHRFHIHLYNADSL 131

  Fly   133 MALILPYHETMIFVQIVKTMRLRSSDGDWYWLRPLQRPGVPLAKTAIINRAASNPAFLGFICQST 197
            :|.:||||||.:||::::.:::.:....|:||.|::..|||||:..::.....:..|:.|||...
Mouse   132 IACVLPYHETRVFVRVIQLLKISNPKHKWFWLSPVKHSGVPLARGTLVTHCYKDLGFMDFICSLV 196

  Fly   198 QKAVKELGP---RAHQLQAQINFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNIDFMAAA 259
            .::||....   .:.:|:..:.|||:.:|.||..|:.|.|..:..:...:.:||.|...|:.||.
Mouse   197 TRSVKAFAEDPGSSTRLRVLLAFYASTIVSALVAAENLSDNVVAKLFPYIQKGLKSSLPDYRAAT 261

  Fly   260 YVIVAQL-----VSRTKLKSKVCNALLERVANCPFERLHSESLLLLVCIYGKQQAALPHFKPETI 319
            |:|:.|:     :..|.:|| :.:.|::.:...|.:  .::.|..|:.:..:|       |||.:
Mouse   262 YMIICQISVKVTMEDTFVKS-LASQLIKTLTKVPSQ--VNDGLGCLIILLQRQ-------KPENL 316

  Fly   320 -----LNLVGKKWLISTLSSLAKG-NIAIQSICM--PLMTGAVAAIRDDDASSNSCKLF---LDN 373
                 |:|.|...||..|..:::. :::....||  .|:...|..|..::|.....:::   |:.
Mouse   317 GEKPFLHLCGVPDLIGLLHGISESYDVSPLLRCMLPHLVASVVQHIAGEEAEGIDGQIYKNHLEE 381

  Fly   374 LLSEVPMPKPTAQQLINCFLDTYVETAIDAPEPMETNS----NEDDDTIVIDSDDEIETEKTTFQ 434
            :|.::|:.......|.:...:.|:  :..:.|..:.|.    ||.
Mouse   382 ILIKIPLTNNLDHLLASHLFEEYI--SYSSQEETQANGVALLNEQ-------------------- 424

  Fly   435 AWYSTYLEKLERRYPEAFDLSVKEALRSKSSTSNRQ---KALKLAL-GFRLNTTDEKAKHAYEKL 495
              :...:..||.:||.|.|..::|.|:..:....::   :.:.|:. |.:....::........|
Mouse   425 --FLPLIRLLESKYPRALDAVLEEHLKEITGLKKQELFHQFISLSTSGGKYQFLEDSDTSLMLSL 487

  Fly   496 YHYSADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLGP 560
            .|..|..||.||.. |:....|.|.......::|.:..|:.||:..||...|| ..|...:..|.
Mouse   488 NHPLAPVRLLAVNH-LKTFMKTSKEGIDETFIKEAILTRLGDDNVDVVLATLS-AFEIFQQHFGV 550

  Fly   561 LPLAQTLCHLLYRAQSEKDEEWQPVVPLAVRHLTSALVSGSYD--TNLVLLALMPLLF------- 616
            .....:|.:|..||...|:|.|..|:.||...|....:....|  .|.|::.|:|.:.
Mouse   551 EETVSSLLNLFQRADLSKNEGWFRVLELAANILIKEEILSKNDQLANQVVVQLLPFMVITSNDIE 615

  Fly   617 -PGEALAEHQHKALRILLGSDFVSKVPFLAELK------VSNKFSDFNVGEHRQHFLDIIASSNQ 674
             |...:|.|..|       |...|..|.|...|      :.::.|...:|...|..:.::.|:
Mouse   616 SPDMKIAIHLSK-------SGICSLHPLLRGWKEALENVIKSRKSREIIGVGNQKMVQLLGSN-- 671

  Fly   675 ELSSQERA-LLQSVEDHGGELYIQKASQLTHLLLLLTAYAKRELQPRESLHMLEKIGLYSRRLQF 738
             ||..||: :|:.|||                  |:.|..|      ||..:.:|:..:. .:..
Mouse   672 -LSLGERSTVLKLVED------------------LVCAGEK------ESYSLKQKVAFHV-TVSV 710

  Fly   739 RVVNGSQNTQNCAPLQLYVDFLL-----------TLVK-NTKW-------TALASTPWNQMTDEL 784
            .:...|...:.|.|..|.|..||           |.|: .::|       ..|....|.:...||
Mouse   711 LISCCSSFQETCFPFALRVFSLLQKKIRKLKSVITAVEIPSEWHLELMLNRGLPEELWVRYVQEL 775

  Fly   785 RLCLR-LLEIICAQVFSEK----ADQPERQEWTRALQQSLQLILPEAQDRLEVLSNFYVFERLPE 844
            ....| ::|.....|||.|    |.:..:...|.|:..:.:.:..:::..|.:|..  :||.|.|
Mouse   776 HGAQRVVMEDAILLVFSMKCFIFAMKAPKSFPTGAMWWNPEQLDEDSRHYLHLLIG--IFEMLLE 838

  Fly   845 LWPRDSDYAVFRLQGFIILE--------------------AVLSNP-----KSQIDCGLVHVLRV 884
            :    ||...||:...:|::                    :.||||     ||::.   ...|.:
Mouse   839 V----SDAMHFRVLIRLIMKVHLQDVLQLFKFFCVLWTYGSSLSNPLNCTVKSELQ---TQALYI 896

  Fly   885 ANACGSPLQTLRVQAIN------ILQLISNRKLVSHVEQLVRSLLQ---------RKSELSMDHE 934
            .:|..|...|...|.:.      ::.|:.|  |.||::::.|:.:|         .|.||.:||
Mouse   897 GSAMLSSQNTQYKQKLASTASPVVMSLLLN--LGSHIKEVRRAAVQCLQALRGVPSKFELVIDH- 958

  Fly   935 QYALILYTILEPEKATAKERLVLSKLKRSVLALASDPKQS-------------------PICTA- 979
                   .|.:.|:.|:....||..|......|.::.||.                   |...|
Mouse   959 -------LIPKAEEITSDATYVLQDLATLFDELQNEEKQKSHQKLSETLRSLLHCVYGCPSYIAK 1016

  Fly   980 SLLAALKHVNDENFLNELLPLGLDSLKTITAGEDNQNIKQLPWPHSEIYKSVIERFEGR------ 1038
            .|:..|:.||.|..|.:|||:                ::||           :|:.|..
Mouse  1017 GLMKVLQGVNSEMVLAQLLPM----------------VEQL-----------LEKVEKEPTAVLK 1054

  Fly  1039 ---VALNVLLRK--DLAWKLFEDSFAQYDTYVQ---LEQKLQP-LPCV---LLNSLTPETFE--- 1088
               |.|::.|.|  :.:..|.:......|.:::   ..::|.| :|.|   .|..:|...|.
Mouse  1055 DEAVVLHLTLGKYNEYSASLLQKDPKSLDLFIKAMHTTKELHPGMPTVRITALEKITKPFFAAVS 1119

  Fly  1089 --QMHAKHKIALIKLIV---ESATNSDNDSIFLASHRLLKRCRLDCQP--LVPILLEMANTKVEK 1146
              |:..|....|..|:|   ::.......|:|.......::.|::.:|  ....|..:..|:.:|
Mouse  1120 DGQVQQKLLCVLFDLLVNCKDAHCVQTVGSVFKGISVDAEQIRIELEPRDKAKSLGTIQQTRRQK 1184

  Fly  1147 KQPVKRRSVQATQLDLTSPYWKQGMTLLELLEHKKQLVGAELLIPPLFELLQACL--TMEEHSAA 1209
            .|..|.:.|::.| ::..|||::...:||||:|||:|...::||||||.||..||  ...|....
Mouse  1185 MQQKKSQDVESVQ-EVEGPYWQRVTLILELLQHKKKLKCPQILIPPLFNLLSRCLEPLSSEQGNM 1248

  Fly  1210 EYPKQLILSSLLHCCQTAQSAGVQLVK-AMPESSFRIELVVQSLRNTRNPQTQQHALLFLTHCAG 1273
            ||.||||||.||:.||.....|.::.| .:.|..|.:||:||.:|.:..|||..||||.|...||
Mouse  1249 EYTKQLILSCLLNICQKLSPDGGRIPKDVVDEEKFNVELIVQCIRLSEMPQTHHHALLLLGTVAG 1313

  Fly  1274 MYPQQVLHKIVEIFTFVGSTVARHDDAFSLHIIHNVVESIIPILL-LNTGHN--------ELVIP 1329
            ::|.:|||.|:.||||:|:.|.|.|||:|..:|...|:.:||.|: .:||.:        ::|:.
Mouse  1314 IFPDKVLHNIMSIFTFMGANVMRLDDAYSFQVISKTVKMVIPALIQSDTGDSVEVTRNVEQIVVK 1378

  Fly  1330 VLKVFADICTDVPVHRRLPLYATLFRVLEPKEHLWQFLCIIFE----SQVLLEQVPQKVSTDKSR 1390
            ::.||.|....||.|||||:...|...|..|:.||..|.::||    ..||:....:|.:..::.
Mouse  1379 IIGVFVDALPHVPEHRRLPILVQLVTTLSAKKFLWILLVLLFEQYVTKTVLVAAYGEKDAILEAD 1443

  Fly  1391 LDF----ARELTLMFEDPTVAIQTCIRLLDYLAKLPATKSSLSGGSGSSVLSTEQQ-------LF 1444
            .:|    ..|.::..:     :|:.:.:|.||.|||..|...:    |..:||:.:       :|
Mouse  1444 TEFWISVCCEFSVQHQ-----VQSLMHILHYLEKLPEEKEEAT----SKTVSTKSEVQDEMLPVF 1499

  Fly  1445 DVRTRTFKQLRHYKYLIMDFLSGISSCNEWEKKMKRPDPNELLPYYQEFILKT-LAYVGVLNGAL 1508
            .|...|.|||||:|||.:.|:|.:.:.|.:.||:......:.|...::.:|:| |:|:..:..::
Mouse  1500 KVDAHTSKQLRHFKYLSVSFMSQLLASNHFLKKVVGSGGPKSLHGLEQGLLETVLSYINTVAQSM 1564

  Fly  1509 EAASETPSLEKFWRVLANHAHDVLDNAIGLLAPQHFISVITELLKHDHVYVRIKVMDLLVTKLSP 1573
            |..::..: .||||.|.:.|:|:||....||..:.|||||..|:.:....||.|.:|||..||..
Mouse  1565 EKNADKLT-GKFWRALLSKAYDMLDKVNALLPTETFISVIRGLVGNPLPSVRRKALDLLNNKLQQ 1628

  Fly  1574 SSDYFQQSNAEHFGVLFAPLQEIINGILEGSSNSA--QQAKLQQTALHALQLLALRHGRDYIEEC 1636
            .:  |.:....|   .|..|..::..|::.....|  :||..:||||:.|:||....|....|..
Mouse  1629 HT--FWRKKMVH---RFLKLVPVLLAIVQHKKREAEDEQAINRQTALYTLKLLCKNFGAQNREPF 1688

  Fly  1637 RSLLATLTKITKRRANVPKAVVGNVVLTLVEICASLKAHALAQLPKFAPQLTELLK---EQVHQM 1698
            ..:|:|..|:.:......|.|:|:.:|.:.|:.::|:|.|:.|||...|.|...:|   |.||..
Mouse  1689 IPVLSTAVKLIEPEKKEEKNVLGSALLCIAEVTSTLEALAIPQLPSLMPSLLTAMKSTSELVHSE 1753

  Fly  1699 ASLKQGPDYVCSTLVTALHKLFKALPLFLGPYLVDIIGGLARLSVQLENPQLLQDKRTQVLKQKL 1763
            ..|        .:.:.||||:.:.||.|:.|||    .||....:.||.........:|. ..:|
Mouse  1754 VCL--------LSALAALHKVVETLPHFISPYL----EGLLTQVIHLEKITREMGSASQA-NIRL 1805

  Fly  1764 ADVWSAVAQGVEVRILVPSCAKAFSSLLEQQAYDELGHLMQQLLLQSVRHNSAAQLQPVQDPLSE 1828
            ..:...:|..:..|:|:|:.:|.|.. :::...:.:|..| .:|.:.:......:|...|..|:.
Mouse  1806 TALKKTLATELSPRVLLPAISKTFKQ-IQKNWKNHMGPFM-SILQEHIGVMKKEELLSHQSQLTT 1868

  Fly  1829 LFLQALNFRLQVRGLGLQRQLVSDVEASITETFVTWILKLSETSFRPMYSRVHKWA-LESTSRET 1892
            .||:||:||.|.....|:.  |...|..|.:..|..::||||.:|||::.::..|| .|...::.
Mouse  1869 FFLEALDFRAQHSEDDLEE--VGKTEGWIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDR 1931

  Fly  1893 RLTYFLLTNRIAEALKSLFVLFASDFVEDSSRLLTEHNSIRPEFEVEEREDDVD----LLMAILN 1953
            .||::.|.:.|||.||.||.|||...|:..:..|.:.|..:.:....:.|.|.:    ||..|||
Mouse  1932 LLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSERDPEKCCLLLQFILN 1996

  Fly  1954 TLHHVFLYCSEDFINDHRFNVLMPPLVNQLENDLVLGNESLQQ----VLSNCIAQFAVA-TNDVM 2013
            .|:.|||:.:::|::..|...||.|||:||||.|. |.|..|:    .|..|||||:|| .:|.|
Mouse  1997 CLYKVFLFDTQNFMSRERAEALMMPLVDQLENRLG-GEERFQERVTKYLVPCIAQFSVAMADDSM 2060

  Fly  2014 WKQLNSQVLLKTRTSNPEVRILAFNSCVAIARKLGESYAALLPETVPFIAELLEDEHQRVEKNTR 2078
            ||.||.|:|||||.|:|:||..|..:.:|:|.||.|:|..||||::||:|||:|||.:.||...:
Mouse  2061 WKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQ 2125

  Fly  2079 TGVQELETILGESVQKY 2095
            ..:|:||.:|||.:|.|
Mouse  2126 KTIQQLEAVLGEPLQSY 2142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..350	CDD:289183	28/126 (22%)
l(2)k09022	NP_609079.2	BP28CT	1818..1966	CDD:214987	52/152 (34%)
Heatr1	NP_659084.3	U3snoRNP10	238..354	CDD:289183	28/125 (22%)
Heatr1	NP_659084.3	BP28CT	1856..2009	CDD:214987	52/154 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843275
Domainoid	1	1.000	316	1.000	Domainoid score	I1281
eggNOG	1	0.900	-	-		E1_KOG1837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34562
Inparanoid	1	1.050	718	1.000	Inparanoid score	I633
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55386
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004191
OrthoInspector	1	1.000	-	-		oto94794
orthoMCL	1	0.900	-	-		OOG6_102005
Panther	1	1.100	-	-	LDO	PTHR13457
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1613
SonicParanoid	1	1.000	-	-		X4007
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790