Protein Alignment l(2)k09022 and toe-1

DIOPT Version :10

• Sequence 1: NP_609079.2
• Gene: l(2)k09022 / 33960
• FlyBaseID: FBgn0086451
• Length: 2096
• Species: Drosophila melanogaster
• Sequence 2: NP_494782.1
• Gene: toe-1 / 173779
• WormBaseID: WBGene00022739
• Length: 1650
• Species: Caenorhabditis elegans
• Alignment Length: 2256
• Identity: 391/2256 - (17%)
• Similarity: 746/2256 - (33%)
• Gaps: 779/2256 - (34%)

  Fly     1 MSTALAQQLQKLAAPQSSVTLADARSRASILFDPKEAATKDRRSIYEIGLTGLQELTDFNPAF-K 64
            |:|:|..||:.|....:.....:.| ..|:|||.|||......:.:.||:.||:::...:|.| .
 Worm     1 MATSLTSQLENLRTSAARHLTVEKR-HVSLLFDRKEANKLSNETAHRIGVAGLEQMKRIDPVFDT 64

  Fly    65 EFQLTLFDEATLTLERSVELPEINKMLDAAIAKFLRLLSPYLLLRPAHMAFEWLLRRFQVHEYNR 129
            ||...||.|..:...||:.....|:.|:..|.|.|..|||||.........|:|:..:|::.:|.
 Worm    65 EFANDLFSEERVDFVRSMLEKGANEELNKQIEKLLLELSPYLQHFACQQVLEFLIHTYQIYSFNA 129

  Fly   130 SEVMALILPYHETMIFVQIVKTMRL---RSSDGDWYWLRPLQRPGVPLAKTAIINRA-ASNPAFL 190
            ..::...||:|||.::.::::.:..   ||.  :|.:::...:...|:..|:|.... :|..:.:
 Worm   130 ETLLLTFLPFHETKVYSRLLRILDFDWKRSK--EWQFMQQFTKTETPIPFTSIARATLSSKHSII 192

  Fly   191 GFICQSTQKAVKELGPRAHQLQAQI--NFYATVVVGALQTAKPLQDWHITTILESLLRGLISDNI 253
            ..|....:.||:.:|....:::..|  ||:|.:::......:.:.:..:..::..:..|:.|...
 Worm   193 TCITDHIRHAVEIVGSDYLEIKHPILFNFHAKLLLSMFTDPEKVDEMMLAKLMPFIENGIKSPMK 257

  Fly   254 DFMAAAYVIVAQLVSRTKLKSKVCNALLERVANCPFERLHSESLLLLVCIYGKQQAALPHFKPET 318
            .|..:|.|:::|||...|||.:|.|
 Worm   258 SFRYSAMVVISQLVLTVKLKDEVLN---------------------------------------- 282

  Fly   319 ILNLVGKKWLISTLSSLAKGNIAIQSICMPLMTGAVAAIRDDDASSNSCKLFL----DNLLSEVP 379
                                     |:|..|:|    .:|.|.|:::...|.:    .|:.|
 Worm   283 -------------------------SMCKLLIT----KMRSDTAAASLSTLMVVFQQQNVQS--- 315

  Fly   380 MPKPTAQQLINCFLDTYVETAIDAPEPMETNSNEDDDT----------IVIDSDDEIETEKTTFQ 434
            :.|.|.::|:.      .|..||..:.::..|...|.|          ||:..|  .|:|..|.
 Worm   316 LSKNTLKKLLR------HEEGIDVWKILKELSERTDTTKFFNVLWKELIVLSKD--AESEDNTL- 371

  Fly   435 AWYSTYLEKLERRYPEAFDLSVKEALRSKSSTSNRQKA--LKLAL--GFRLNTTDEKAKHAYEKL 495
                            |.|:.: |.:...|..:..|..  |||.|  |...|..|.|
 Worm   372 ----------------AIDVLI-ETIEDASILTGDQAGTILKLILQEGMDGNIFDNK-------- 411

  Fly   496 YHYSADWRLSAVQKLLQNLNVTKKRERSVKLLQECLPDRINDDSGAVVSTLLSLPTEELAEMLGP 560
                        :||..|:       |::.:       |......|:.:.|.:...:.|..:|
 Worm   412 ------------KKLKSNI-------RAIGM-------RFAKQFDAIHAELKAKDKKTLKNVL-- 448

  Fly   561 LPLAQTLCHLLYRAQSEKDEEWQPVVPLAVRHLTSALVSGSYDTNLVLLALMPLLFPGEALAEHQ 625
                             |:.:.:.:|.                            |..||:|..|
 Worm   449 -----------------KEYQIEDIVQ----------------------------FASEAVAATQ 468

  Fly   626 HKALRILLGSDFVSKVPFLAELKVSNKFSDFNVGEHRQHFLDIIASSNQELSSQERALLQSVEDH 690
            .:           ..:..::|...|:|                    ..:|::.|:|
 Worm   469 SE-----------ESIEIISEEAPSSK--------------------KIKLTASEKA-------- 494

  Fly   691 GGELYIQKASQLTHLLLLLTAYAKRELQPRESLHMLEKIGLYSRRLQFRVVNGSQNTQNCAPLQL 755
                  ||.:|.:.       :||||                       |.:|.       |:.
 Worm   495 ------QKLAQSSE-------FAKRE-----------------------VFSGD-------PIN- 515

  Fly   756 YVDFLLTLVKNTKWTALASTPWNQMTDELRLCLRLLEIICAQVFSEKADQPERQEWTRALQQSLQ 820
                     |.|:|  |....|:::                             ||.
 Worm   516 ---------KATEW--LNGEKWDKV-----------------------------EWA-------- 532

  Fly   821 LILPEAQDRLEVLSNFYVFERLPELWPRDSDYAVFRLQGFIILEAVLSNPKSQIDCGLVHVLRVA 885
                                 |.|:..|...|
 Worm   533 ---------------------LNEMAQRGEKY--------------------------------- 543

  Fly   886 NACGSPLQTLRVQAINILQLISNRKLVSHVEQLVRSLLQRKSELSMDHEQYALILYTILEPEKAT 950
                                 .:||:...|||.|
 Worm   544 ---------------------FSRKVEDDVEQFV------------------------------- 556

  Fly   951 AKERLVLSKLKRSVLALASDPKQSPICTASLLAALKHVNDENFLNELLPLGLDSLKTITAGEDNQ 1015
                                                               |:.:|.:..|
 Worm   557 ---------------------------------------------------LEIVKVVGVG---- 566

  Fly  1016 NIKQLPWPHSEIYKSVIERFEGRVALNVLLRKDLAWKLFEDSFAQYDTYVQLEQKLQPLPCVLLN 1080
            .:||:               :|......|...:|..:...|...::|...::..|
 Worm   567 GVKQI---------------DGGSVKAALAGANLNPQFVADLLTKFDGVSEIAPK---------- 606

  Fly  1081 SLTPETFEQMHAKHKIALIKLIVESATNSDNDSIFLASHRLLKRCRLDCQPLVPILLEMANTKVE 1145
                        :.|.|..|.:||....::..                        .|..|.:|
 Worm   607 ------------RTKGAQKKNLVEKTFGTEES------------------------WEAFNQRV- 634

  Fly  1146 KKQPVKRRSVQATQLDLTSPYWKQGMTLLELLEHKKQLVGAELLIPPLFELLQACLTMEEHSAAE 1210
                                     :.:|:||..::.:..:|.::..||.:::...:..:..::.
 Worm   635 -------------------------VFVLDLLNARQIIPSSEKVLAALFAVVKQVNSKSDVESSS 674

  Fly  1211 YPKQLILSSLLHCCQTAQSAGVQLVKAMPE------SSFRIELVVQSLRNTRNPQTQQHALLFLT 1269
            |.:.|.:::            ::.:...||      |...::.|::::|:|.|....:..|..:.
 Worm   675 YQQHLAVNA------------IRKILEHPEKTKIGASEVDMDCVIETMRSTHNHHLLRDCLRLIV 727

  Fly  1270 HCAGMYPQQVLHKIVEIFTFVGSTVARHDDAFSLHIIHNVVESIIPILLLNTG--------HNEL 1326
            ..|...|..|:..::.:|||:|:.:.|.|:..:|.|:...|||:...::.::|        ..|.
 Worm   728 AAAKHTPNSVVKHVMSVFTFMGNGMLRKDNELTLSIVEKTVESLFSTIINSSGQAVLTKQQQTEK 792

  Fly  1327 VIPVLKVFADICTDVPVHRRLPLYATLFRVLEPKEHLWQFLCIIF--------ESQVLLEQVPQK 1383
            :|.:.::||....|:|.|||..:...:.|.::.:......|.::.        .|....::..::
 Worm   793 LIELARLFAASAIDIPAHRRARIAQAIARAVQAENASTVVLVLVSSFCARWQRSSDAAAQEAMKR 857

  Fly  1384 VSTDKSRLDFARELTLMFEDPTVAIQTCIRLLDYLAKLPATKSSLSGGSGSSVLSTEQQLFDVRT 1448
            .|...:..|.|.|| |...:|...:.:.:.:.:|:.:|...|.:.|..:...:   :..:||...
 Worm   858 GSDQDAYDDLAIEL-LSALNPFEQLSSVLEMCEYVRRLGGDKPAKSTTTKKDL---DTMIFDRTA 918

  Fly  1449 RTFKQLRHYKYLIMDFLSGISSCNEWEKKMKRPDPNEL----LPYYQEFILKTLAYVGVLN-GAL 1508
            :|..::||::|:::..:|.|.|.....:::...|..||    ||..:..|..::......| .|.
 Worm   919 QTLPRIRHFRYVVVTLISRIFSNRVLIERLAAYDDEELLKNALPLGKRLIECSVELDEFANKEAN 983

  Fly  1509 EAASETPSLEKFWRVLANHAHDVLDNAIGLL----APQHFISVITELLKHDHVYVRI--KVMDLL 1567
            :.....|..:::|...|:....|.:....||    |.:....|:.|.:....:..::  ||:.|.
 Worm   984 DQDGSDPQAQRYWVAFASRTEVVSEKLRHLLPGGVAARLIADVLQECVNDKKMSYKMCEKVLQLA 1048

  Fly  1568 VTKLSPSSDYFQQSNAEHFGVLFAPLQEIINGILEGSSNSAQQAKLQQTALHALQLLALRHG--- 1629
            ..||......|..|......::  .|.:.:|..:...:.|.::.::.|.:.:.|:|:|....
 Worm  1049 NIKLGHDRYLFADSGINEKELI--TLAQALNKFIVAETKSEEKMRMCQNSAYTLKLIAKNLPSQS 1111

  Fly  1630 -----RDYIEECRSLLATLTKITKRRANVPKAVVGNVVL-------------------TLVEICA 1670
                 .|.::.|.|:::...|:.:.       :.|||:|                   :|::.|.
 Worm  1112 ESLVLADTMQRCVSIVSQYQKLDEN-------LTGNVLLLAGELIRSHNMRSTIHHATSLLKTCL 1169

  Fly  1671 SLKAHALAQLPKFAPQLTEL-----------------LKEQVHQMASLKQGPD--YVCSTLVTAL 1716
            :.....:|:..|  ||....                 :::|  .:...|.|.|  .:||  :|.:
 Worm  1170 ATVQECIARFSK--PQYDSAASPGSSVAGGRGNRGHRIRQQ--SLGGNKFGSDTLLICS--LTCI 1228

  Fly  1717 HKLFKALPLFLGPYLVDIIGGLARLSVQLENP-QLLQDKRTQVLKQKLADVWSAVAQG------- 1773
            .:::.....|:.....|:|....||..:..:| :||      .|.|..:...:|...|
 Worm  1229 QRVYDQFASFVVESTGDVIIRYCRLIARFGDPSELL------ALNQPSSSTTAAFQGGSQTSGFG 1287

  Fly  1774 ------------------VEVRILVPSCAKAFSSL-LEQQAYDELGHLM------QQLLLQSVRH 1813
                              :|:|:|.....|....| .|::|...|.:|:      |......:..
 Worm  1288 SKTGIHHRLSLIRRSLLSIELRVLPAHIVKTVGELKTEKKALSALFNLLTGYIETQHQQKPEILR 1352

  Fly  1814 NSAAQLQPVQDPLSELFLQALNFRLQVRGLGLQRQLVSDVEASITETFVTWILK----LSETSFR 1874
            .|..||:  :..:|::....|..|.|.|    |.....:|| .:..|...:::.    |||..||
 Worm  1353 KSVIQLR--RTFVSDVITPTLIVRSQER----QSDQFENVE-KLEHTVFNFVISIASILSEVEFR 1410

  Fly  1875 PMYSRVHKWA---------LESTSRETRLTYFLLTNRIAEALKSLFVLFASDFVEDSSRLLTEHN 1930
            .:.:.:..||         |.:..|...|.:|  .|.:..:..||.:.:....:|.|:.:|.:.|
 Worm  1411 TVVNELVAWAEPGLEAKADLAARLRLVSLLHF--ANDLYTSFNSLALPYFGRILEISALVLKKCN 1473

  Fly  1931 SI-----------RPEFEVEEREDDVDLLMA---ILNTLHHVFLYCSEDFINDHRFNVLMPPLVN 1981
            :.           .....:|..|.|:.|.:|   |.|...|      .||....|..::...:||
 Worm  1474 ATLLLGTDELLLSGKRGSIEALETDLALTLAIDVISNAARH------RDFFTVDRCQLVSDVIVN 1532

  Fly  1982 QLENDLVLGNES-LQQVLSNCIAQFAVATNDVMWKQLNSQVLLKTRTSNPEVRILAFNSCVAIAR 2045
            :|.|..|.|:|. ....|...|.:...|..| .:.:|.::::||||.|..::|..|......:.:
 Worm  1533 ELVNTKVEGHEKRCSDHLVPAIYRIGNADPD-SFPELLNKIMLKTRDSRAKIRYRALIVLELLIK 1596

  Fly  2046 KLGESYAALLPETVPFIAELLEDEHQRVEKNTRTGVQELETILGES 2091
            ::|:.....|...:||:.||:|||:::||...:..:..|:...||:
 Worm  1597 EIGDGVQPHLSILLPFLNELIEDENKQVEAQCQKVINSLQHKFGET 1642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09022	NP_609079.2	U3snoRNP10	236..353	CDD:463559	17/116 (15%)
		BP28CT	1818..1966	CDD:214987	37/174 (21%)
toe-1	NP_494782.1	U3snoRNP10	240..357	CDD:463559	32/194 (16%)
		BP28CT	1353..1475	CDD:471550	30/130 (23%)