DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sens-2 and ZSCAN5C

DIOPT Version :9

Sequence 1:	NP_001285692.1	Gene:	sens-2 / 33957	FlyBaseID:	FBgn0051632	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001345342.1	Gene:	ZSCAN5C / 649137	HGNCID:	34294	Length:	496	Species:	Homo sapiens

Alignment Length:	645	Identity:	157/645 - (24%)
Similarity:	236/645 - (36%)	Gaps:	190/645 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SSSASNSASSSAAATVPLQVRDLSALTAMATIPSP-TQLLHQRIQMSADAALGHHQQQPAQNPNP 117
            :||.|...|.::..:.|.|           ::||| ||             ||:|      :.:|
Human     6 TSSWSLGESCNSPGSEPPQ-----------SMPSPATQ-------------LGNH------DSDP 40

  Fly   118 NPNHPQPQMPPASTSPHEYAPMSAFKAV-----------LPKKRNSDDASL--AFSISRLVKTEQ 169
            ...|...:|   .:.|.|..|:.|.:.:           |..|....|..:  .|.||   ..::
Human    41 ETCHVNFRM---FSCPKESDPIQALRKLTELCHLWLRPDLHTKEQILDMLVMEQFMIS---MPQE 99

  Fly   170 LTAMAAAVGLKPPTPLEDNNNSISMLSKNQQMHQQHHQQSHLAQRPKP----AFISASEKLRRQS 230
            |..:....|::....|||      :|..|              :|||.    :|: ..|.|.::|
Human   100 LQVLVMMNGVQSCKDLED------LLRNN--------------RRPKKWSVVSFL-GKEYLMQES 143

  Fly   231 RSRSRSRSRSPCSSQIDMEDADSNHSHRSLHSRSRSRSRSRSHSRSRSHSSSSSVELEVDSPPGS 295
                            |:|.|::..|.|. ..|..|..|:.|.::.......:|.||:.     .
Human   144 ----------------DVEMAEAPASVRD-DPRHVSSQRTSSVNQMCPEEGQASQELQT-----L 186

  Fly   296 PRISSPSGASASASELLI----TANGGGRSIGSK---KSDLFSVSALLRRDEPP----PQRRTPR 349
            ||:  |:.......:.|:    ...|..:::..|   :.||..     .|:|.|    |:.:.|.
Human   187 PRV--PALFRRQEEDFLLPETTVMKGDPKALRPKPTLEKDLEE-----DREENPGLTSPEPQLPN 244

  Fly   350 SPPLGHLTSSGLAMPFNPLEAMRQGYPPNYDAAMFQRPLFSPALPFFAAVAFHQGQQQQQQQQQQ 414
            ||       :|:.       ..::|..|...|::......:|:    |.|...:
Human   245 SP-------TGVV-------GAKEGKEPQKRASVENVDADTPS----ACVVERE----------- 280

  Fly   415 QSGLAAGYHPDSQENLFRLRSLMVPLQSAGQNNSSAAAAAAAAAAAAVGVGVGVGVGVPPNGGHL 479
                 |..|..|:.:...||.|          ..|...|.:.:.....|....||....|....:
Human   281 -----ASTHSGSRGDALNLRGL----------KRSKPDATSISQEEPQGEATPVGNRESPGQAEI 330

  Fly   480 GLPHSPHLHHFHHMAAKWPGLHQFSDLYSCMKCEKMFSTPHGLEVHSRRTHHGKKPYACELCNKT 544
            ...|||        ....|..|                 |.|.||..      ..|:|||:|.|.
Human   331 NPVHSP--------GPAGPVSH-----------------PSGQEVKE------LLPFACEVCGKR 364

  Fly   545 FGHEVSLSQHRAVHNVEKVFECKQCGKRFKRSSTLSTHLLIHSDTRPYPCNYCGKRFHQKSDMKK 609
            |.:...|:.|...|..|::|:|..|||||.:...|..|...|:..|||.|:.|.|:|.|||.:|.
Human   365 FKYRGKLAVHTRSHTGERLFQCNLCGKRFMQRIGLQFHQRTHTGERPYTCDICQKQFTQKSYLKC 429

  Fly   610 HTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGYKPFSCKLCHKAFQRKVDLRRHKET 669
            |...||||||.:|:.|.|.|:..:||..|.|.|:|.||..|..|.:||.|...||||::|
Human   430 HKRSHTGEKPFECKDCKKVFTYKANLKEHQRIHSGEKPHKCSKCPRAFGRPATLRRHQKT 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens-2	NP_001285692.1	COG5048	<504..672	CDD:227381	65/166 (39%)
		C2H2 Zn finger	509..530	CDD:275368	4/20 (20%)
		zf-H2C2_2	522..545	CDD:290200	8/22 (36%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		zf-H2C2_2	550..575	CDD:290200	11/24 (46%)
		C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		zf-H2C2_2	579..603	CDD:290200	10/23 (43%)
		C2H2 Zn finger	594..614	CDD:275368	9/19 (47%)
		zf-H2C2_2	606..631	CDD:290200	12/24 (50%)
		C2H2 Zn finger	622..642	CDD:275368	8/19 (42%)
		zf-H2C2_2	634..657	CDD:290200	10/22 (45%)
		C2H2 Zn finger	650..677	CDD:275368	10/20 (50%)
ZSCAN5C	NP_001345342.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		14/61 (23%)
		SCAN	40..124	CDD:153421	20/109 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..188		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..347		36/217 (17%)
		zf-C2H2	356..378	CDD:333835	8/21 (38%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	371..393	CDD:372612	9/21 (43%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	410..>473	CDD:227381	31/62 (50%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-C2H2	468..490	CDD:333835	10/22 (45%)
		C2H2 Zn finger	470..490	CDD:275368	10/20 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4275
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050