DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sens-2 and sqz

DIOPT Version :9

Sequence 1:	NP_001285692.1	Gene:	sens-2 / 33957	FlyBaseID:	FBgn0051632	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	111/407 - (27%)
Similarity:	164/407 - (40%)	Gaps:	103/407 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 LGHLTSSGLA---MPFNPLEAMRQGYPPNYDAAMFQRPLFSPALPFFAAVAFHQGQQQQQQQ--- 411
            |||||::.|.   .||| :...||......|.::..            .:..||.|...:||
  Fly    27 LGHLTTAQLVHDYKPFN-ISEFRQNVAERLDYSLKN------------GLVQHQQQMVMEQQPHP 78

  Fly   412 -QQQQSGLAAGYHPDSQENLFRLR-SLMVPLQSAGQNNSSAAAAAAAAAAAAVGVGVGVGVGVPP 474
             ||||..|   :||..|::..:|: |...|       ||                        ||
  Fly    79 DQQQQQHL---HHPQQQQHPPQLKVSYSAP-------NS------------------------PP 109

  Fly   475 NGGHLGLPHSPHLHHFHHMAAKWPGLHQFSDLYSCMKCEKMFSTPHGLEVHSRRTHHGK-KPYAC 538
            .      ||......:.  ..:.|...|.|   |........|:|   |..|||....: |||.|
  Fly   110 T------PHEQQEQKYD--PNRSPPRQQMS---SASGSGSNGSSP---EEESRRGDGDQAKPYKC 160

  Fly   539 ELCNKTFGHEVSLSQHRAVHNVEKVFECKQCGKRFKRSSTLSTHLLIHSDTRPYPCNY--CGKRF 601
            ..|:|:|.:...||||..:|...|.:.|:.|.::|.:.|.|..|:..|:..:||.|.:  |.|.|
  Fly   161 GSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAF 225

  Fly   602 HQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGYKPFS---CKLCHKAFQRKVDL 663
            .|.|:::.|:..|..:||.||..|.|.||....|:.|..||...|...   |.||.|::.::..|
  Fly   226 SQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYL 290

  Fly   664 RRH----------KETQHT---------------DLRVHLGKVDFMSAAAAAAASAELSAAAAAA 703
            ::|          ::.:||               .|.:....::.::||..|...|: ||||:.|
  Fly   291 QKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGAD-SAAASLA 354

  Fly   704 AAAGGSVP--GGGPPGS 718
            .|....:|  ||.|.|:
  Fly   355 EAIQQQLPQAGGQPYGN 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens-2	NP_001285692.1	COG5048	<504..672	CDD:227381	57/183 (31%)
		C2H2 Zn finger	509..530	CDD:275368	6/20 (30%)
		zf-H2C2_2	522..545	CDD:290200	10/23 (43%)
		C2H2 Zn finger	538..558	CDD:275368	8/19 (42%)
		zf-H2C2_2	550..575	CDD:290200	9/24 (38%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		zf-H2C2_2	579..603	CDD:290200	9/25 (36%)
		C2H2 Zn finger	594..614	CDD:275368	7/21 (33%)
		zf-H2C2_2	606..631	CDD:290200	9/24 (38%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)
		zf-H2C2_2	634..657	CDD:290200	9/25 (36%)
		C2H2 Zn finger	650..677	CDD:275368	9/51 (18%)
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		zf-H2C2_2	172..197	CDD:290200	9/24 (38%)
		zf-C2H2	186..208	CDD:278523	6/21 (29%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-C2H2_8	191..271	CDD:292531	28/79 (35%)
		zf-H2C2_2	200..227	CDD:290200	9/26 (35%)
		C2H2 Zn finger	216..238	CDD:275368	7/21 (33%)
		C2H2 Zn finger	246..266	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100