DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sens-2 and ZSCAN5B

DIOPT Version :9

Sequence 1:	NP_001285692.1	Gene:	sens-2 / 33957	FlyBaseID:	FBgn0051632	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001073925.2	Gene:	ZSCAN5B / 342933	HGNCID:	34246	Length:	495	Species:	Homo sapiens

Alignment Length:	604	Identity:	145/604 - (24%)
Similarity:	217/604 - (35%)	Gaps:	172/604 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SADAALGHHQQQPAQNPNPNPNHPQPQMPPASTSPHEYAPMSAFKAV-----------LPKKRNS 152
            |.:..||:|.:      ||...|...:|   .:.|.|..|:.|.:.:           |..|...
Human    28 SPETQLGNHDR------NPETWHMNFRM---FSCPEESDPIQALRKLTELCHLWLRPDLHTKEQI 83

  Fly   153 DDASL--AFSISRLVKTEQLTAMAAAVGLKPPTPLEDNNNSISMLSKNQQMHQQHHQQSHLAQRP 215
            .|..:  .|.||   ..::|..:....|::....|||      :|..|              :||
Human    84 LDMLVMEQFMIS---MPQELQVLVKVNGVQSCKDLED------LLRNN--------------RRP 125

  Fly   216 KP---AFISASEKLRRQSRSRSRSRSRSPCSSQIDMEDADS------NHSHRSLHSRSRSRS--- 268
            |.   ..:...|.|...|   ....:.:|.|.:.|..|..|      |..|.......|.:.
Human   126 KKWSIVNLLGKEYLMLNS---DVEMAEAPASVRDDPRDVSSQWASSVNQMHPGTGQARREQQILP 187

  Fly   269 RSRSHSRSRSHSSSSSVELEVDSPPGSPRISSPSGASASASELLITANGGGRSIGSKKSDLFSVS 333
            |..:.||.:.........::|...|.|||...                       :.:.||..
Human   188 RVAALSRRQGEDFLLHKSIDVTGDPNSPRPKQ-----------------------TLEKDLKE-- 227

  Fly   334 ALLRRDEPP----PQRRTPRSPPLGHLTSSGLAMPFNPLEAMRQGYPPNYDAAMFQRPLFSPALP 394
               .|:|.|    |:.:.|:||              |.:.| ::|..|...|::......:|:
Human   228 ---NREENPGLSSPEPQLPKSP--------------NLVRA-KEGKEPQKRASVENVDADTPS-- 272

  Fly   395 FFAAVAFHQGQQQQQQQQQQQSGLAAGYHPDSQENLFRLRSLMVPLQSAGQNNSSAAAAAAAAAA 459
              |.|.             ::..|.   |..::.:...|.|   |.:|...       |::.:..
Human   273 --ACVV-------------EREALT---HSGNRGDALNLSS---PKRSKPD-------ASSISQE 309

  Fly   460 AAVGVGVGVGVGVPPNGGHLGLPHSPHLHHFHHMAAKWPGLHQFSDLYSCMKCEKMFSTPHGLEV 524
            ...|....||....|....:...|||        ....|..|                 |.|.|.
Human   310 EPQGEATPVGNRESPGQAEINPVHSP--------GPAGPVSH-----------------PDGQEA 349

  Fly   525 HSRRTHHGKKPYACELCNKTFGHEVSLSQHRAVHNVEKVFECKQCGKRFKRSSTLSTHLLIHSDT 589
            .:      ..|:||::|||:|.:...||.||..|..::.|:|..|.|||.:.|.|..|..:|:..
Human   350 KA------LPPFACDVCNKSFKYFSQLSIHRRSHTGDRPFQCDLCRKRFLQPSDLRVHQRVHTGE 408

  Fly   590 RPYPCNYCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGYKPFSCKLCH 654
            |||.|:.|.|||..:|.::.|..|||||:|.||:.|.|.||...||..|.|.|:|.||:.|..|.
Human   409 RPYMCDVCQKRFAHESTLQGHKRIHTGERPFKCKYCSKVFSHKGNLNVHQRTHSGEKPYKCPTCQ 473

  Fly   655 KAFQR----KVDLRRHKET 669
            |||::    |..|:.|:||
Human   474 KAFRQLGTFKRHLKTHRET 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens-2	NP_001285692.1	COG5048	<504..672	CDD:227381	65/170 (38%)
		C2H2 Zn finger	509..530	CDD:275368	3/20 (15%)
		zf-H2C2_2	522..545	CDD:290200	7/22 (32%)
		C2H2 Zn finger	538..558	CDD:275368	9/19 (47%)
		zf-H2C2_2	550..575	CDD:290200	11/24 (46%)
		C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		zf-H2C2_2	579..603	CDD:290200	11/23 (48%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		zf-H2C2_2	606..631	CDD:290200	12/24 (50%)
		C2H2 Zn finger	622..642	CDD:275368	9/19 (47%)
		zf-H2C2_2	634..657	CDD:290200	11/22 (50%)
		C2H2 Zn finger	650..677	CDD:275368	10/24 (42%)
ZSCAN5B	NP_001073925.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		4/17 (24%)
		SCAN	40..124	CDD:153421	20/109 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..183		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..347		32/194 (16%)
		zf-C2H2	355..377	CDD:395048	10/21 (48%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..394	CDD:404364	11/23 (48%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..450	CDD:404364	12/23 (52%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-H2C2_2	453..478	CDD:404364	13/24 (54%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4275
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050