DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sens-2 and pag-3

DIOPT Version :9

Sequence 1:	NP_001285692.1	Gene:	sens-2 / 33957	FlyBaseID:	FBgn0051632	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_510480.1	Gene:	pag-3 / 181588	WormBaseID:	WBGene00003909	Length:	336	Species:	Caenorhabditis elegans

Alignment Length:	189	Identity:	116/189 - (61%)
Similarity:	133/189 - (70%)	Gaps:	23/189 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 KPYACELCNKTFGHEVSLSQHRAVHNVEKVFECKQCGKRFKRSSTLSTHLLIHSDTRPYPCNYCG 598
            ||:.|:.|.|.|....:|.||:.||..:|.||||||||.||||||||||||||||||||||.|||
Worm   124 KPFHCQKCTKLFSTIAALEQHQQVHVSDKQFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCEYCG 188

  Fly   599 KRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGYKPFSCKLCHKAFQRKVDL 663
            ||||||||||||||||||||||||.|||||||||||||||:|||||:|||:|.:|.:.||||||.
Worm   189 KRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGFKPFACDVCGRTFQRKVDR 253

  Fly   664 RRHKETQHTDLRVHLGKVDFMSAAAAAAASAELSAAAAAAAAAGGSVPGG--GPPGSQG 720
            |||:|:.|.      |..:  ...:|:..|::||             |.|  .||.|.|
Worm   254 RRHRESHHP------GHPE--ECVSASQISSDLS-------------PKGYMTPPTSNG 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens-2	NP_001285692.1	COG5048	<504..672	CDD:227381	104/137 (76%)
		C2H2 Zn finger	509..530	CDD:275368
		zf-H2C2_2	522..545	CDD:290200	5/10 (50%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		zf-H2C2_2	550..575	CDD:290200	15/24 (63%)
		C2H2 Zn finger	566..586	CDD:275368	18/19 (95%)
		zf-H2C2_2	579..603	CDD:290200	22/23 (96%)
		C2H2 Zn finger	594..614	CDD:275368	18/19 (95%)
		zf-H2C2_2	606..631	CDD:290200	23/24 (96%)
		C2H2 Zn finger	622..642	CDD:275368	17/19 (89%)
		zf-H2C2_2	634..657	CDD:290200	15/22 (68%)
		C2H2 Zn finger	650..677	CDD:275368	13/26 (50%)
pag-3	NP_510480.1	C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		zf-H2C2_2	140..165	CDD:290200	15/24 (63%)
		zf-C2H2	154..176	CDD:278523	20/21 (95%)
		C2H2 Zn finger	156..176	CDD:275368	18/19 (95%)
		COG5048	164..>233	CDD:227381	65/68 (96%)
		zf-H2C2_2	169..193	CDD:290200	22/23 (96%)
		C2H2 Zn finger	184..204	CDD:275368	18/19 (95%)
		zf-H2C2_2	196..221	CDD:290200	23/24 (96%)
		C2H2 Zn finger	212..232	CDD:275368	17/19 (89%)
		zf-H2C2_2	224..247	CDD:290200	15/22 (68%)
		C2H2 Zn finger	240..260	CDD:275368	12/19 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166268
Domainoid	1	1.000	50	1.000	Domainoid score	I7817
eggNOG	1	0.900	-	-		E33208_3BCNN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto19142
orthoMCL	1	0.900	-	-		OOG6_108076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3187
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.670