Protein Alignment sens-2 and Gfi1

DIOPT Version :10

• Sequence 1: NP_723223.1
• Gene: sens-2 / 33957
• FlyBaseID: FBgn0051632
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_001254550.1
• Gene: Gfi1 / 14581
• MGIID: 103170
• Length: 489
• Species: Mus musculus
• Alignment Length: 616
• Identity: 224/616 - (36%)
• Similarity: 272/616 - (44%)
• Gaps: 188/616 - (30%)

  Fly   102 AALGHHQQQPAQNPNPNPNHPQPQ----MPPASTSPH---EYAPMSAFKAVLPKKRNSDDASLAF 159
            :||....:.||.:....|..|..|    .||.....|   ||..:..|
Mouse    13 SALPSAPEFPASDDQGKPGGPLCQERAAPPPGRQLQHENSEYPRVQTF----------------- 60

  Fly   160 SISRLVKTEQLTAMAAAVGLKPPTPLEDNNNSISMLSKNQQMHQQHHQQS-------HLAQRPKP 217
                   .::||.|..                 |.|.|:::.|..|..:|       .|...|.|
Mouse    61 -------VQRLTTMPR-----------------SFLVKSKKAHSYHQPRSPGPDYSLRLETVPAP 101

  Fly   218 -----AFISASEKLRRQSRSRSRSRSRSPCSSQIDMEDADSNHSHRSLHSRSRSRSRSRSHSRSR 277
                 ..:||.|       |:...|.|....||:                         :.:..|
Mouse   102 GRAEGGAVSAGE-------SKMEPRERLSPDSQL-------------------------TEAPDR 134

  Fly   278 SHSSSSSVELEVDSP---------PGSPRISSPSGASASASELLITANGGGRSIGSKKSDLFSVS 333
            :.:|.:|.|..|..|         |.||.:|..|..|..            ||:
Mouse   135 ASASPNSCEGSVCDPCSEFEDFWRPPSPSVSPASEKSLC------------RSL----------- 176

  Fly   334 ALLRRDEPPPQRRTPRSPPLGHLTSSGLAMPFNPLEAMRQGYPPNYDAAMFQRPLFSPALPFFAA 398
                 ||..|.     :.|......||||  .:.|..:.|.|   ...:..:|   |..|..|..
Mouse   177 -----DEAQPY-----TLPFKPYAWSGLA--GSDLRHLVQSY---RQCSALER---SAGLSLFCE 223

  Fly   399 VAFHQGQQQQQQQQQQQSGLAAGYHPDSQENLFRLRSLMVPLQSAGQNNSSAAAAAAAAAAAAVG 463
            .....|:...:...:|.:| .||                     |||..|...|..|.:||   |
Mouse   224 RGSEPGRPAARYGPEQAAG-GAG---------------------AGQPGSCGVAGGATSAA---G 263

  Fly   464 VGVGVGVGVPPNGGHLGLP-------HSPHLHHFHHMAAKWPGLHQFSDL-----------YSCM 510
            :|: .|...|...|....|       :..|.|..|  |.|..|:...|:|           |.|:
Mouse   264 LGL-YGDFAPAAAGLYERPSTAAGRLYQDHGHELH--ADKSVGVKVESELLCTRLLLGGGSYKCI 325

  Fly   511 KCEKMFSTPHGLEVHSRRTHHGKKPYACELCNKTFGHEVSLSQHRAVHNVEKVFECKQCGKRFKR 575
            ||.|:||||||||||.||:|.|.:|:|||:|.|||||.|||.||:|||:.|:.|:||.|||.|||
Mouse   326 KCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKR 390

  Fly   576 SSTLSTHLLIHSDTRPYPCNYCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSR 640
            |||||||||||||||||||.||||||||||||||||:||||||||||||||||||||||||||||
Mouse   391 SSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSR 455

  Fly   641 KHTGYKPFSCKLCHKAFQRKVDLRRHKETQH 671
            ||||:|||.|.||.|.||||||||||:||||
Mouse   456 KHTGFKPFGCDLCGKGFQRKVDLRRHRETQH 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sens-2	NP_723223.1	COG5048	<504..672	CDD:227381	137/179 (77%)
		C2H2 Zn finger	509..530	CDD:275368	16/20 (80%)
		SUF4-like	534..>589	CDD:411020	40/54 (74%)
		C2H2 Zn finger	538..558	CDD:411020	14/19 (74%)
		C2H2 Zn finger	538..558	CDD:275368	14/19 (74%)
		C2H2 Zn finger	566..586	CDD:411020	17/19 (89%)
		C2H2 Zn finger	566..586	CDD:275368	17/19 (89%)
		C2H2 Zn finger	594..614	CDD:275368	17/19 (89%)
		zf-H2C2_2	606..631	CDD:463886	23/24 (96%)
		C2H2 Zn finger	622..642	CDD:275368	19/19 (100%)
		C2H2 Zn finger	650..677	CDD:275368	18/22 (82%)
Gfi1	NP_001254550.1	COG5048	<321..483	CDD:227381	131/161 (81%)
		C2H2 Zn finger	324..345	CDD:275368	16/20 (80%)
		C2H2 Zn finger	353..373	CDD:275368	14/19 (74%)
		C2H2 Zn finger	381..401	CDD:275368	17/19 (89%)
		C2H2 Zn finger	409..429	CDD:275368	17/19 (89%)
		C2H2 Zn finger	437..457	CDD:275368	19/19 (100%)
		C2H2 Zn finger	465..484	CDD:275368	14/18 (78%)