DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv2 and Atp1b3

DIOPT Version :9

Sequence 1:	NP_001014475.1	Gene:	nrv2 / 33953	FlyBaseID:	FBgn0015777	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_037045.1	Gene:	Atp1b3 / 25390	RGDID:	2172	Length:	279	Species:	Rattus norvegicus

Alignment Length:	324	Identity:	83/324 - (25%)
Similarity:	135/324 - (41%)	Gaps:	74/324 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RPKKKSLKQ-------MVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDP 79
            :.:|||..|       .:|:.....:.||:..||..|.:||:.|||.||||....||...|||:.
  Rat     3 KTEKKSFHQSLAEWKLFIYNPTSGEFLGRTSKSWGLILLFYLVFYGFLAALFTFTMWVMLQTLND 67

  Fly    80 RIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTP 144
            .:||:   |..| .:|||...|.||. .::.|   |..:....||.:.:.|.:||..|.|.
  Rat    68 EVPKY---RDQI-PSPGLMVFPKPPT-ALDYT---YSMSDPHTYKKFVEDLKNFLKPYSVE---- 120

  Fly   145 GRGQNIYNCD----YNQPPPKGQVCDVDIKTWSPCT--KENNYSYHKSAPCIFLKLNKIYGWIPE 203
             ..:|:.:|.    ::|..|....|...:.....|:  .::|:.|.|..||:.:|:|:|...:|:
  Rat   121 -EQKNLTDCPGGALFHQEGPDYSACQFPVSLLQECSGVNDSNFGYSKGQPCVLVKMNRIIELVPD 184

  Fly   204 YYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLP------IRG 262
                      ..|     ||..:.|                    :|||..:...|      ::.
  Rat   185 ----------GAP-----YITCITK--------------------EENIANIVTYPDDGLIDLKY 214

  Fly   263 FPGYFYPYQNSEGYLSPLVAVH--FQRPKRGIIINVECRAWARNIIHDRKER---IGSVHYELL 321
            ||  :|..:...||..|||||.  |........:.:||:......:.::.||   :|.|.::::
  Rat   215 FP--YYGKKRHVGYRQPLVAVQVIFGADATKKEVTIECQIDGTRNLKNKNERDKFLGRVSFKVI 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv2	NP_001014475.1	Na_K-ATPase	24..317	CDD:278704	82/316 (26%)
Atp1b3	NP_037045.1	Na_K_ATPase_bet	1..279	CDD:273446	83/324 (26%)
Atp1b3	NP_037045.1	immunoglobulin-like. /evidence=ECO:0000250	186..279		25/118 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm9102
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930