DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv1 and Atp1b4

DIOPT Version :9

Sequence 1:	NP_001260163.1	Gene:	nrv1 / 33952	FlyBaseID:	FBgn0015776	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_598451.1	Gene:	Atp1b4 / 67821	MGIID:	1915071	Length:	356	Species:	Mus musculus

Alignment Length:	305	Identity:	86/305 - (28%)
Similarity:	132/305 - (43%)	Gaps:	48/305 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KKQTFSEMIYNPQEGTFFGRTGKSWSQLLLFYTIFYIVLAALFTICMQGLLSTISDTEPKWKLQD 84
            |.|..:|.:::|::.....|||:|.|.:|:.|..||..|||:.|:.:..|...||...|.:..|.
Mouse    84 KLQIVNEYLWDPEKRMSLARTGQSRSLILVIYFFFYASLAAVITLFIYMLFLAISPYMPTFTEQV 148

  Fly    85 SLIGTNPGLGFRPLSEQTERGSVIAFDGKKPAESDYWIELIDDFLRDYNHTEGRDMK-HCGFGQV 148
            .    .||:..||.:....    ..|:..:|.....::..::.||:.||.:...:|. .|..|:.
Mouse   149 K----PPGVMIRPFAHSLN----FNFNVSEPETWQRYVISLNGFLQGYNDSLQEEMNIDCPPGRY 205

  Fly   149 L-------EPTDVCVVNTDLFGGCSKANN--YGYKTNQPCIFLKLNKIFGWIPEVYDKEEKDMPD 204
            .       |....|.........||...:  :||.|.||||.||:|:|.|:.||..|
Mouse   206 FIQDGDEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPEFGD-------- 262

  Fly   205 DLKKVINETKTEERQQVWVSCNGHLGKDKENFQNIRYFP-SQGFPSYYYPF---LNQPGYLSPLV 265
                           .|.|||....| |:.:.::|.|:| |..|...|||:   |....|.||||
Mouse   263 ---------------PVKVSCKVQKG-DENDIRSINYYPESASFDLRYYPYYGKLTHVNYTSPLV 311

  Fly   266 AVQFNSPPKGQMLDVECRAWAKNIQYSGSVRDR-KGSVTFQILLD 309
            |:.|....|.|.:.|:|:...|.| .:..:.|| .|.:.|.:.::
Mouse   312 AMHFTDVVKNQAVPVQCQLKGKGI-VNDVINDRFVGRIIFTLNIE 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv1	NP_001260163.1	Na_K-ATPase	20..303	CDD:278704	85/297 (29%)
Atp1b4	NP_598451.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..78
Atp1b4	NP_598451.1	Na_K-ATPase	84..349	CDD:278704	85/297 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4946
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I4549
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm8856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980