DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv1 and atp1b3a

DIOPT Version :9

Sequence 1:	NP_001260163.1	Gene:	nrv1 / 33952	FlyBaseID:	FBgn0015776	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_571296.2	Gene:	atp1b3a / 30468	ZFINID:	ZDB-GENE-990415-167	Length:	278	Species:	Danio rerio

Alignment Length:	329	Identity:	97/329 - (29%)
Similarity:	150/329 - (45%)	Gaps:	74/329 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKNNGKGAKGEFEFPQPAKKQTFSEMIYNPQEGTFFGRTGKSWSQLLLFYTIFYIVLAALFTIC 65
            |||.:...|:|:    :|  :.::.:.||||:.|..||||.::|..:||||.:||..|||:|...
Zfish     1 MSKKSENPAEGK----EP--ESSWKDAIYNPRTGELFGRTARNWGLILLFYLVFYGFLAAMFVFT 59

  Fly    66 MQGLLSTISDTEPKWKLQDSLIGTNPGLGFRPLSEQTERGSVIAFDGKKPAESDYWIELIDDFLR 130
            :..:|.|::|..||::  |.:  .:|||..||.|...|      |:...|.|...:::.::.||.
Zfish    60 LWVMLQTLNDDTPKYR--DRV--ASPGLVIRPNSLNIE------FNRSDPLEYGQYVQHLESFLH 114

  Fly   131 DYNHTEGRDMKHCGFGQVLEP-----TDVCVVNTDLFGGCS--KANNYGYKTNQPCIFLKLNKIF 188
            .||.:|......|..||..|.     ..||.....|...||  :...:||...|||:.:|:|:|.
Zfish   115 QYNDSEQAKNDLCMAGQYSEQDGESLKKVCQFKRSLLYSCSGMEDTTFGYAKGQPCVIVKMNRII 179

  Fly   189 GWIPEVYDKEEKDMPDDLKKVINETKTEERQQVWVSCNGHLGKDKENFQNIRYFPSQG------F 247
            |..|.                         ...:::|.....|..:    ::|||.:|      |
Zfish   180 GLKPS-------------------------GDPYINCTSKSVKPLQ----MQYFPHEGTIDRMYF 215

  Fly   248 PSYYYPFLNQPGYLSPLVAVQ-------FNSPPKGQMLDVECRAWAKNIQYSGSVRDR-KGSVTF 304
            |  ||......||:.|||||:       :||.     |.|||:....|:: :...||: .|.|||
Zfish   216 P--YYGKKTHKGYVQPLVAVKLLLKKEDYNSE-----LIVECKVEGSNLK-NNDERDKFLGRVTF 272

  Fly   305 QILL 308
            ::|:
Zfish   273 RVLV 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv1	NP_001260163.1	Na_K-ATPase	20..303	CDD:278704	87/303 (29%)
atp1b3a	NP_571296.2	Na_K-ATPase	13..271	CDD:278704	88/306 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5399
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4678
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm6361
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4478
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010