Protein Alignment ZNF678 and Zfp623

DIOPT Version :10

• Sequence 1: NP_848644.2
• Gene: ZNF678 / 339500
• HGNCID: 28652
• Length: 580
• Species: Homo sapiens
• Sequence 2: NP_001385918.1
• Gene: Zfp623 / 102547932
• RGDID: 7635192
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 228/540 - (42%)
• Similarity: 318/540 - (58%)
• Gaps: 74/540 - (13%)

Human    61 LDPA---QRNLYRDVMFENYRNLVSLAILSYSIQD-----------LLPEQDMKDLCQKVTLTRH 111
            |:|:   .|..:.|.:.:...|..:.::.|.|.||           .:...|...:|.|    ..
  Rat     9 LEPSVSESREFHEDRLAQLLENPETQSLESPSCQDGGFTQMTVAHWKIQTGDTAPVCSK----SG 69

Human   112 RSWGLD-NLHLVKDWRTVNEGKGQKEYCNRLTQCSSTKSKIFQCIECGRNFSWRSILTEHKRIHT 175
            |:..|| ||.:::  |.:.||:              |:|    |...|:||.:.|.:..|:..|:
  Rat    70 RNPILDSNLLILQ--RELIEGE--------------TRS----CGVGGKNFPFNSDVDPHQVSHS 114

Human   176 GEKPYKCEECGKVFNRCSNLTKHKRIHTGEKPYKCDECGKVFNWWSQLTNHKKIHTGEKPYKCDE 240
            |||.|||:.|||.|::.|.||:|:|:||.::...|:.|||.|..::.|..|:.:||||||:|
  Rat   115 GEKSYKCDHCGKGFSQTSLLTEHQRVHTRDRLCVCNVCGKDFIHYANLMEHQLVHTGEKPFK--- 176

Human   241 CDKVFNWWSQLTSHKKIHSGEKPYPCEECGKAFTQFSNLTQHKRIHTGEKPYKCKECCKAFNKFS 305
                                     |.:|||||...|:|.:|:|:||.|:|::||||.|.|::.|
  Rat   177 -------------------------CAQCGKAFCHSSDLLRHQRVHTRERPFECKECGKGFSQSS 216

Human   306 NLTQHKRIHTGEKPYKCEECGNVFNECSHLTRHRRIHTGEKPYKCEECGKAFTQFASLTRHKRIH 370
            .|.:|:||||||:||:|.|||..|...|.|.||.:|||..|.|:|.:|||||...:.|..|:|||
  Rat   217 LLIRHQRIHTGERPYECNECGKSFIRSSSLIRHYQIHTEVKQYECRDCGKAFRHRSDLIEHQRIH 281

Human   371 TGEKPYQCEECGKTFNRCSHLSSHKRIHTGEKPYKCEECGRTFTQFSNLTQHKRIHTGEKPYKCK 435
            |||:|::|.||||.|.|.|.|..|:||||||:||.|.|||:.|:|.||.|||:|||||||.|:|.
  Rat   282 TGERPFECHECGKAFIRSSKLIQHQRIHTGERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECN 346

Human   436 ECGKAFNKFSSLTQHRRIHTGVKPYKCEECGKVFKQCSHLTSHKRIHTGEKPYKCKECGKAFYQS 500
            ||||||...|.|.:|::||||.:.|:|:||||.|.|.:|||.|::||||::|::||:|||||.||
  Rat   347 ECGKAFFLSSYLIRHQKIHTGERVYECKECGKAFLQKAHLTEHQKIHTGDRPFECKDCGKAFIQS 411

Human   501 SILSKHKRIHTEEKPYKCEECGKAFNQFSSLTRHKRIHTGEKRYKCKECGKGFY-------QSSI 558
            |.|..|:.:||.||||.|..|||.|.|.|:..:|:::||.||.||..|.||...       |..:
  Rat   412 SKLLLHQIVHTGEKPYVCSYCGKGFIQRSNFLQHQKMHTEEKLYKYSEHGKDLAPPPDLVPQEDL 476

Human   559 HSKYKRIYTGEEPDKCKKCG 578
            ......::.||.....::||
  Rat   477 SLSETSVHLGETATDQERCG 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF678	NP_848644.2	KRAB	43..83	CDD:460171	5/24 (21%)
		COG5048	138..536	CDD:227381	194/397 (49%)
		C2H2 Zn finger	154..174	CDD:275368	6/19 (32%)
		C2H2 Zn finger	182..202	CDD:275368	10/19 (53%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	238..258	CDD:275368	0/19 (0%)
		C2H2 Zn finger	266..286	CDD:275368	10/19 (53%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	378..398	CDD:275368	11/19 (58%)
		C2H2 Zn finger	406..426	CDD:275368	12/19 (63%)
		C2H2 Zn finger	434..454	CDD:275368	10/19 (53%)
		C2H2 Zn finger	462..482	CDD:275368	11/19 (58%)
		C2H2 Zn finger	490..510	CDD:275368	12/19 (63%)
		C2H2 Zn finger	518..538	CDD:275368	8/19 (42%)
		zf-H2C2_2	530..555	CDD:463886	10/31 (32%)
Zfp623	NP_001385918.1	C2H2 Zn finger	93..113	CDD:275370	6/19 (32%)
		COG5048	<108..322	CDD:227381	114/241 (47%)
		C2H2 Zn finger	121..141	CDD:275368	10/19 (53%)
		C2H2 Zn finger	149..169	CDD:275368	7/19 (37%)
		C2H2 Zn finger	177..197	CDD:275368	10/19 (53%)
		C2H2 Zn finger	205..225	CDD:275368	10/19 (53%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		C2H2 Zn finger	261..281	CDD:275368	9/19 (47%)
		C2H2 Zn finger	289..309	CDD:275368	11/19 (58%)
		zf-C2H2	315..337	CDD:395048	13/21 (62%)
		C2H2 Zn finger	317..337	CDD:275368	12/19 (63%)
		zf-H2C2_2	329..352	CDD:463886	17/22 (77%)
		C2H2 Zn finger	345..365	CDD:275368	10/19 (53%)
		zf-H2C2_2	357..382	CDD:463886	13/24 (54%)
		C2H2 Zn finger	373..393	CDD:275368	11/19 (58%)
		zf-H2C2_2	385..410	CDD:463886	16/24 (67%)
		C2H2 Zn finger	401..421	CDD:275368	12/19 (63%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)