Protein Alignment ZNF678 and LOC101885920

DIOPT Version :10

• Sequence 1: NP_848644.2
• Gene: ZNF678 / 339500
• HGNCID: 28652
• Length: 580
• Species: Homo sapiens
• Sequence 2: XP_021331366.2
• Gene: LOC101885920 / 101885920
• -ID: -
• Length: 501
• Species: Danio rerio
• Alignment Length: 484
• Identity: 221/484 - (45%)
• Similarity: 317/484 - (65%)
• Gaps: 14/484 - (2%)

Human    96 EQDMKDLCQKVTLTRHRSWGLDNLHLVKDWRTVNEGKGQKEYCNRLTQCSSTKSKI--------- 151
            :::.:|:..:.|.|..:....:...|:::    |||..::::..::.:.:..::::
Zfish     5 KEESEDVKIEETFTIKQEDLQEQTDLIEE----NEGSKEEKHHVKIEEKNHLQTEVILKRRDKNC 65

Human   152 FQCIECGRNFSWRSILTEHKRIHTGEKPYKCEECGKVFNRCSNLTKHKRIHTGEKPYKCDECGKV 216
            |.|.:||::|..:..|..|.|||||||.:.|.:|||.|::.|||..|..|||||||:.|.:|||.
Zfish    66 FTCTQCGKSFGRKDDLKIHMRIHTGEKTFTCTQCGKSFSQSSNLNLHMMIHTGEKPFTCTQCGKS 130

Human   217 FNWWSQLTNHKKIHTGEKPYKCDECDKVFNWWSQLTSHKKIHSGEKPYPCEECGKAFTQFSNLTQ 281
            |...|.|..|.:|||||||:.|.:|.|.|...|.|..|.:||:||||:.|.:|||:|...|:|.:
Zfish   131 FIHSSSLNQHMRIHTGEKPFTCTQCGKSFIHSSSLNQHMRIHTGEKPFSCTQCGKSFDCSSHLNK 195

Human   282 HKRIHTGEKPYKCKECCKAFNKFSNLTQHKRIHTGEKPYKCEECGNVFNECSHLTRHRRIHTGEK 346
            |.|:||||||:.|.:|.|:|::.|:|.:|.|.||.|||:.|.:||..|::.|.|..|..||||||
Zfish   196 HMRVHTGEKPFTCTQCGKSFSQSSSLNKHIRNHTREKPFTCTQCGKSFSQSSFLNLHMMIHTGEK 260

Human   347 PYKCEECGKAFTQFASLTRHKRIHTGEKPYQCEECGKTFNRCSHLSSHKRIHTGEKPYKCEECGR 411
            |:.|.:|||:|...:.|.:|.|:||||||:.|.:|||:|...|.|:.|.||||||||:.|.:||:
Zfish   261 PFTCTQCGKSFDCSSHLNKHMRVHTGEKPFTCTQCGKSFINSSSLNQHMRIHTGEKPFTCTQCGK 325

Human   412 TFTQFSNLTQHKRIHTGEKPYKCKECGKAFNKFSSLTQHRRIHTGVKPYKCEECGKVFKQCSHLT 476
            .|::.|:|.:|.||||.||.:.|.:|||:|::.|....|..||||.||:.|.:|||.|.:.|.|.
Zfish   326 RFSRSSSLKKHMRIHTREKTFICTQCGKSFSQSSFFNLHMIIHTGEKPFPCSQCGKSFIRSSSLN 390

Human   477 SHKRIHTGE-KPYKCKECGKAFYQSSILSKHKRIHTEEKPYKCEECGKAFNQFSSLTRHKRIHTG 540
            .|..||||| ||:.|.:|||.|..||.|::|.|:||||||:.|.:|||:|:..|.|.:|.|:|||
Zfish   391 LHMMIHTGEKKPFTCTQCGKRFIHSSSLNQHMRMHTEEKPFTCTQCGKSFDCSSHLNKHMRVHTG 455

Human   541 EKRYKCKECGKGFYQSSIHSKYKRIYTGE 569
            ||.:.|.:|||.|.|||..:|:.||:|.|
Zfish   456 EKPFTCSQCGKSFSQSSSLNKHMRIHTRE 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF678	NP_848644.2	KRAB	43..83	CDD:460171
		COG5048	138..536	CDD:227381	195/407 (48%)
		C2H2 Zn finger	154..174	CDD:275368	7/19 (37%)
		C2H2 Zn finger	182..202	CDD:275368	9/19 (47%)
		C2H2 Zn finger	210..230	CDD:275368	8/19 (42%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		C2H2 Zn finger	266..286	CDD:275368	9/19 (47%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	462..482	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..510	CDD:275368	10/19 (53%)
		C2H2 Zn finger	518..538	CDD:275368	9/19 (47%)
		zf-H2C2_2	530..555	CDD:463886	13/24 (54%)
LOC101885920	XP_021331366.2	COG5048	62..477	CDD:227381	209/414 (50%)
		C2H2 Zn finger	68..88	CDD:275368	7/19 (37%)
		C2H2 Zn finger	96..116	CDD:275368	9/19 (47%)
		C2H2 Zn finger	124..144	CDD:275368	8/19 (42%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	292..312	CDD:275368	9/19 (47%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		C2H2 Zn finger	405..425	CDD:275368	10/19 (53%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..481	CDD:275368	10/19 (53%)