DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and si:dkey-181m9.8

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	XP_696033.5	Gene:	si:dkey-181m9.8 / 567642	ZFINID:	ZDB-GENE-070912-399	Length:	867	Species:	Danio rerio

Alignment Length:	898	Identity:	248/898 - (27%)
Similarity:	385/898 - (42%)	Gaps:	207/898 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2103 EDIMEEDEDLADDDEPLQSQIPLDIEPVISPALSVTPTNQETDTIAH---TEVVSSTGTRL---- 2160
            ::::|:..:|:.|...||..:...:.|           |.:...:.:   |..|:..|.:.
Zfish    22 DEVLEDIRNLSADFPHLQLYVDYYLYP-----------NNDKKKLVYLGGTVPVAYEGGKYNIPV 75

  Fly  2161 -----ETELPNPAMESILPSQSVQEDIK---VEA------------------IPIQSAPPIADSE 2199
                 ||...||....:.||.|:..:.|   |:|                  :||.....||..:
Zfish    76 CIWIHETHPKNPPRCFVCPSPSMVINTKSSNVDANGRVLLHCLSNWKIGWSNLPIVLEEMIAAFQ 140

  Fly  2200 -------TRPAEQPVELVLEIPSE-VEPTPVEE-PTALPITPAPPIVDSESRPVEPPVETVLEEP 2255
                   |.||:.|  ....:|:| |:|.||.. .:::|
Zfish   141 RETPLFATYPAQTP--QTKHLPAELVQPNPVSSYGSSIP-------------------------- 177

  Fly  2256 KKVTPSMKGKTANSGTASKGPSTSSSTKTNKSTVSKIPKPTNEPTNKSNSTPLNKKVPLRSKSFS 2320
                   |..||..|..|                      ::.|.:..|:.|.:.|..:.....|
Zfish   178 -------KTSTAQHGVLS----------------------SSVPQHVCNTLPQSTKSQMNLNQVS 213

  Fly  2321 APMGISSVKR--IQE-----VYLQKQSSSIATSRVPL---KSSPVTKKS-INDAISRF------- 2367
             .|.:|.|:|  .||     :....|||..:....|.   .|:|.:..| ::|....|
Zfish   214 -EMEMSGVRRSYTQELLDFGITFGAQSSETSHQTNPFITPASAPTSSTSDVDDIDDMFKSLHVQR 277

  Fly  2368 --NSNQADGPSTSGAAAAAAAALLKPRSQPRIPKKKYHETCFSDDDYETSATEEEQEE-----PN 2425
              |..|.|........|..|                 .:.|.......:...:|..:.     |.
Zfish   278 VINMYQLDTREQDVVLAGGA-----------------WQDCVGGARVHSGLADEHHKVVVSGLPV 325

  Fly  2426 LAEPQKAEQLKRKMSMPVFR-----------AYPSVQ--------------EPVIEDP------- 2458
            ...|.|   :|.|:::...|           .||:.|              |.|::.|
Zfish   326 GVSPSK---MKNKLTIYFQRRHNAGGEVLDIRYPAAQPDQAWVLFRNRRDAEHVLKQPDRKIGIN 387

  Fly  2459 ----AILARKYVDQELVTNIA--EAQIAATLVSMK---FSEDVALWAARECSDLDQAIAMLQQEC 2514
                :|..:|:.|.|:...|.  :|::..:::|::   ||....|.|.:.|.||..|:..|..:|
Zfish   388 EQHFSIQLKKFKDMEIPGGIQGDKAEMFRSIMSLEGCSFSSTDVLEAVQSCRDLPSALKYLCHDC 452

  Fly  2515 ELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHLE 2579
            .:|......|:||:|..|....|:.|.|.||:..|.:::|....||.|.||::.. .:.||. :|
Zfish   453 PICQEQVSFNRMVTMTHCSCTFCESCFKKYFSSVIKEKNIVHAVCPLCNLPDVRG-GRREDT-ME 515

  Fly  2580 YFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTC 2644
            |||.||..::..||:.:|||||||||||:|.:.|||:||..|..|......:.|:.||.||..||
Zfish   516 YFSLLDTQIRYYLDSQIHELFQRKLRDRALQEMPNFRWCAHCCFGLLHEADRLRMDCPSCGKSTC 580

  Fly  2645 AQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTC 2709
            .:|::||..||||.|||.:.||::.|.||.|...:::.|::|.|||||||||:.||||||:||.|
Zfish   581 FKCKRPWAPQHEGISCEKFKEWEQLNSPEYQNSRLEQLLSRNKIDCPKCKFRFFLARGGCLHFRC 645

  Fly  2710 TQCKFEFCYGCARPFMMGAKCTVSTYCAKLGLHAHHPRNCLFYLRDKIPLQLQFLLKEQNVKFDT 2774
            |||:.|||.||::||..|:.|..|..||..|||||||||||::|||....:|:.||:...|   :
Zfish   646 TQCQHEFCGGCSQPFKQGSTCNFSIECAAKGLHAHHPRNCLYHLRDWSVPRLRTLLQRYGV---S 707

  Fly  2775 EPMQIKDESSSSSKARAQARCPIPLQKETPQGLV-DTVCNTEVPDKHAGMCRTHYVEYLAGKVAK 2838
            .|:....:....  ..::..|.:...:||  |.| :..|..:...:::|.|..||.|.|...:..
Zfish   708 HPLMFSPKHPMG--RHSKGICGVMEFQET--GAVKEEACGRQAFPEYSGYCTLHYKEVLVELINS 768

  Fly  2839 AGIDPLPIFDLTDCVQELRRRGIALPERGPWDTDEIYKNMCSEVIKKHIPLKS 2891
            .|:||:.:.|..:...|:.|..:.||||.|.:.|:.|.:...:::|:.:.|.|
Zfish   769 NGLDPVVLLDGAELRAEMDRWKVPLPERHPLEPDQRYDDRLRQILKERVVLGS 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	32/186 (17%)
		RING-HC_RNF169	2513..2563	CDD:319465	16/49 (33%)
		IBR	2598..2660	CDD:214763	32/61 (52%)
		IBR	<2690..2724	CDD:396187	24/33 (73%)
		E3_UbLigase_RBR	2760..2858	CDD:407926	22/98 (22%)
si:dkey-181m9.8	XP_696033.5	UEV	26..142	CDD:283415	24/126 (19%)
		RRM_RBM43	316..393	CDD:240990	12/79 (15%)
		zf-RING_2	450..500	CDD:290367	16/49 (33%)
		IBR	534..593	CDD:279784	30/58 (52%)
		IBR	609..663	CDD:279784	32/53 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006359
OrthoInspector	1	1.000	-	-		oto39777
orthoMCL	1	0.900	-	-		OOG6_106001
Panther	1	1.100	-	-	O	PTHR16004
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910