DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LUBEL and rnf216

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	XP_687871.3	Gene:	rnf216 / 559441	ZFINID:	ZDB-GENE-081104-199	Length:	834	Species:	Danio rerio

Alignment Length:	890	Identity:	181/890 - (20%)
Similarity:	283/890 - (31%)	Gaps:	311/890 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2081 NTYNEHA-------SYIEEASTGDEGTEIEDIMEEDEDLADDDEPLQSQIPLDIEPVISPALSVT 2138
            ||:...|       |||..:|:.|                .||||::         .:.....|.
Zfish    17 NTHRSRAKRVRTRTSYITISSSSD----------------SDDEPVR---------FVPNGTVVV 56

  Fly  2139 PTNQETDTIAHTEVVSSTGTRLETELPNPAMESILPSQSVQEDIKVEAIPIQSAPPIADSETRPA 2203
            ..::|.:.::..|           ..|:|..|.|.|:      .|..|   .:.|.:|...:|
Zfish    57 KDDEEEEEVSILE-----------PQPSPHRELIRPA------AKWGA---STFPSLASGSSR-- 99

  Fly  2204 EQPVELVLEIPSEVEPTP----------VEEPTALPITP------APPIVDSESRPVEPPVETVL 2252
             .|.......||.|...|          ..:..|:|.|.      .||:.|.:|.|::
Zfish   100 -HPTSAHAHPPSVVAAHPTLGNQAIGVLTTDQNAVPSTSREHALRRPPLRDKDSLPLQ------- 156

  Fly  2253 EEPKKVTPSMK--------GKTANSGTASKG--------PSTSSSTK---TNKSTV--------- 2289
            .:|...|.|:.        ..|..||.:..|        |.|..:.|   |.:.||
Zfish   157 TDPSSSTHSVNQANSAFSPPSTTESGQSDSGHKIEVVVWPRTERTIKRPRTPQETVLVEVRRDEQ 221

  Fly  2290 -------SKIPKPT-NEPTNKSNSTPLNKKVPLRSKSFSAPMGISSVKRIQEVYLQKQSSSIA-- 2344
                   :::|.|. ||  ....|.|....:|..|...|..:   .||.:.:::...|.:.:|
Zfish   222 PLAPGIPAQLPAPADNE--RPGPSMPREPLIPQDSHRTSLDL---LVKGVTDLFPDVQDAYVAEL 281

  Fly  2345 TSRVPLK-------------------SSPVTKKSI----NDAISRFNSNQAD-------GPSTSG 2379
            ..|..||                   :|.:|:.|:    ||:.::.:.|..|       ||....
Zfish   282 IERGDLKDLNVICNILLENPDYPKKANSVLTQSSVLLETNDSETQESENYFDYFKLKTVGPEVVV 346

  Fly  2380 AAAAAAA-------------ALLKPRSQPRIPKKKYHETC--FSDDDYETSATEEEQEEPN---- 2425
            .||....             ||...:....|.:|...|..  :.::..:.|..::.:.|||
Zfish   347 QAADMLMGDFRMLSCQDIKWALNCLKGHYAITRKALFEALKKWQENSTDPSGKKKRRREPNERAY 411

  Fly  2426 --LAEPQKAEQLKRKM-SMPVFRAYPSVQEPVIEDPAILARKYVDQELVTNIAEAQIAATLVSMK 2487
              ....|.:.:|:||| .:...|.:....|..:|...:...::.:|: ...:||
Zfish   412 IDFKFEQGSFKLERKMYFLEKNRRWSRGNETTLEASLVKELQFYEQK-AKEMAE----------- 464

  Fly  2488 FSED--VALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCL--HKCCKQCAKSY---- 2544
             .||  :||....|....|..:.    ||..|...:...:|.   :|.  |..||:|...|
Zfish   465 -HEDFLLALQVNEEQYQKDGQLI----ECGCCCGEFAFEEMT---QCTDGHLFCKECLVKYAQEA 521

  Fly  2545 -FTVQITDRSIND--CSCPF--------------CKLPELSNE----AQHEDEHLEY-FSNLDIF 2587
             |....::.|..|  |:|.|              ||..|...|    |...||.:.. |.|
Zfish   522 VFGSGRSELSCMDGNCTCSFPNSELEKVLPENILCKYYERQAEEAVAATCADELVRCPFCN---- 582

  Fly  2588 LKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWE 2652
            ..::||.||           ||...||                      |.|...:|.:|...|
Zfish   583 FPALLDKDV-----------SLFSCPN----------------------PRCRKESCRKCHVVW- 613

  Fly  2653 RQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARG-----GCMHFTCTQC 2712
            ::|.|.:||..||   .::..|:....::..|.....|.||      |.|     ||....| :|
Zfish   614 KEHAGKTCEQVLE---RDEIRLRVAFEEKMTAARVRKCHKC------ATGLVKSEGCNRMWC-RC 668

  Fly  2713 KFEFCYGCARPF-----------MMGAKCTVSTYCAKLGLHAHHPRNCLFYLRDKIPLQ-----L 2761
            ....||.|..|.           ..||.|   .:|.|..|...             |.|     :
Zfish   669 GAYMCYLCREPINGYNHFCQHARSPGAPC---RHCKKCSLWTD-------------PTQDDERII 717

  Fly  2762 QFLLKEQNVKFDTEPMQIKDESSSSSKARAQARCPIPLQKE--TP 2804
            |.:.||...:.:.:..| .::..::.|.......|||.::.  ||
Zfish   718 QEIQKEGEAELNKKTTQ-PNQPETTGKRVGPPPEPIPAKRPRVTP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	41/199 (21%)
		RING-HC_RNF169	2513..2563	CDD:319465	16/72 (22%)
		IBR	2598..2660	CDD:214763	11/61 (18%)
		IBR	<2690..2724	CDD:396187	12/38 (32%)
		E3_UbLigase_RBR	2760..2858	CDD:407926	11/52 (21%)
rnf216	XP_687871.3	PARM	<77..>212	CDD:293666	32/153 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810