DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and RNF31

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	NP_060469.4	Gene:	RNF31 / 55072	HGNCID:	16031	Length:	1072	Species:	Homo sapiens

Alignment Length:	464	Identity:	171/464 - (36%)
Similarity:	245/464 - (52%)	Gaps:	19/464 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  2434 QLKRKMSMPV-FRAYPSVQEPVIE----DPAILARKYVDQELVTNIAEAQIAATLVS---MKFSE 2490
            :|:|:...|. .|.:.|..||...    |...|.|:.:....:.:...|::|.:|:.   ..:..
Human   611 ELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYEL 675

  Fly  2491 DVALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSIN 2555
            ...:.|.|...|......:|.|||.:|..:.|.|:|.::..|....|..|.:.:||:.:.::.|.
Human   676 GDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHIT 740

  Fly  2556 DCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQ 2620
            |..||.|..|:|:::.|    .|.|||.|||.|:..|:.|.:.||.:||.:..|::||.|.||.|
Human   741 DMVCPACGRPDLTDDTQ----LLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQ 801

  Fly  2621 CSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQ 2685
            ||.||....:|....||.|....|.:|::.||.||.|.|||.:..|||.||||.||||:..:|.:
Human   802 CSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQGLAMYLQE 866

  Fly  2686 NGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCARPFMMGAKCTVSTYCAKLGLHAHHPRNCL 2750
            ||||||||||.|:|||||||||.||||:.:||.||...|....||.......|..||.||||:||
Human   867 NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCL 931

  Fly  2751 FYLRDKIPLQLQFLLKEQNVKFDTEPMQIKDESSSSSKARAQARCPIPLQKETPQGLVDTVCNTE 2815
            |||||...|:||.||::.||.|:|||       .:.::|.....|.:..|||.|.||.|..|..|
Human   932 FYLRDWTALRLQKLLQDNNVMFNTEP-------PAGARAVPGGGCRVIEQKEVPNGLRDEACGKE 989

  Fly  2816 VPDKHAGMCRTHYVEYLAGKVAKAGIDPLPIFDLTDCVQELRRRGIALPERGPWDTDEIYKNMCS 2880
            .|..:||:|:.||.|||...:....:||..::::.:......|.....|:....:....|:....
Human   990 TPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLL 1054

  Fly  2881 EVIKKHIPL 2889
            :.:.:.:||
Human  1055 QKLTEEVPL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384
		RING-HC_RNF169	2513..2563	CDD:319465	15/49 (31%)
		IBR	2598..2660	CDD:214763	26/61 (43%)
		IBR	<2690..2724	CDD:396187	24/33 (73%)
		E3_UbLigase_RBR	2760..2858	CDD:407926	32/97 (33%)
RNF31	NP_060469.4	Polyubiquitin-binding	1..485
		PUB_RNF31	52..153	CDD:198422
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..290
		RanBP2-type Zn finger	304..323	CDD:275376
		RanBP2-type Zn finger	354..373	CDD:275376
		RanBP2-type Zn finger	413..432	CDD:275376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..484
		HOIP-UBA	483..627	CDD:293283	4/15 (27%)
		Interaction with RBCK1	563..616		2/4 (50%)
		UBA_RNF31	571..625	CDD:270510	4/13 (31%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	695..929		109/237 (46%)
		NMD3	699..>749	CDD:282790	15/49 (31%)
		IBR	779..841	CDD:214763	26/61 (43%)
		LDD domain	910..1072		54/161 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155303
Domainoid	1	1.000	135	1.000	Domainoid score	I4994
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1424
Isobase	1	0.950	-	0	Normalized mean entropy	S7707
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006359
OrthoInspector	1	1.000	-	-		oto90094
orthoMCL	1	0.900	-	-		OOG6_106001
Panther	1	1.100	-	-	LDO	PTHR16004
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700