Protein Alignment LUBEL and RNF31

DIOPT Version :10

• Sequence 1: NP_723214.2
• Gene: LUBEL / 33950
• FlyBaseID: FBgn0031857
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_060469.4
• Gene: RNF31 / 55072
• HGNCID: 16031
• Length: 1072
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 171/464 - (36%)
• Similarity: 245/464 - (52%)
• Gaps: 19/464 - (4%)

  Fly  2434 QLKRKMSMPV-FRAYPSVQEPVIE----DPAILARKYVDQELVTNIAEAQIAATLVS---MKFSE 2490
            :|:|:...|. .|.:.|..||...    |...|.|:.:....:.:...|::|.:|:.   ..:..
Human   611 ELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYEL 675

  Fly  2491 DVALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSIN 2555
            ...:.|.|...|......:|.|||.:|..:.|.|:|.::..|....|..|.:.:||:.:.::.|.
Human   676 GDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHIT 740

  Fly  2556 DCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQ 2620
            |..||.|..|:|:::.|    .|.|||.|||.|:..|:.|.:.||.:||.:..|::||.|.||.|
Human   741 DMVCPACGRPDLTDDTQ----LLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQ 801

  Fly  2621 CSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQ 2685
            ||.||....:|....||.|....|.:|::.||.||.|.|||.:..|||.||||.||||:..:|.:
Human   802 CSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQGLAMYLQE 866

  Fly  2686 NGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCARPFMMGAKCTVSTYCAKLGLHAHHPRNCL 2750
            ||||||||||.|:|||||||||.||||:.:||.||...|....||.......|..||.||||:||
Human   867 NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCL 931

  Fly  2751 FYLRDKIPLQLQFLLKEQNVKFDTEPMQIKDESSSSSKARAQARCPIPLQKETPQGLVDTVCNTE 2815
            |||||...|:||.||::.||.|:|||       .:.::|.....|.:..|||.|.||.|..|..|
Human   932 FYLRDWTALRLQKLLQDNNVMFNTEP-------PAGARAVPGGGCRVIEQKEVPNGLRDEACGKE 989

  Fly  2816 VPDKHAGMCRTHYVEYLAGKVAKAGIDPLPIFDLTDCVQELRRRGIALPERGPWDTDEIYKNMCS 2880
            .|..:||:|:.||.|||...:....:||..::::.:......|.....|:....:....|:....
Human   990 TPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLL 1054

  Fly  2881 EVIKKHIPL 2889
            :.:.:.:||
Human  1055 QKLTEEVPL 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Activator_LAG-3	<326..451	CDD:151935
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:465229
		PRK12323	<1291..>1402	CDD:481241
		rne	<1482..1771	CDD:236766
		Not5	<1647..>2001	CDD:444384
		DUF5585	<2138..>2378	CDD:465521
		DamX	<2154..>2254	CDD:442497
		mRING-HC-C4C4_RBR_HOIP	2512..2565	CDD:438293	17/52 (33%)
		BRcat_RBR_HOIP	2595..2671	CDD:438998	33/75 (44%)
		Rcat_RBR_HOIP	2672..2756	CDD:439012	51/83 (61%)
		E3_UbLigase_RBR	2760..2858	CDD:436265	32/97 (33%)
RNF31	NP_060469.4	Polyubiquitin-binding	1..485
		PUB_1	1..65	CDD:465785
		PUB_RNF31	52..153	CDD:198422
		Bbox1_HOIP	217..258	CDD:380873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..290
		RanBP2-type Zn finger	304..323	CDD:275376
		RanBP2-type Zn finger	354..373	CDD:275376
		RanBP2-type Zn finger	413..432	CDD:275376
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..484
		HOIP-UBA	483..627	CDD:465229	4/15 (27%)
		Interaction with RBCK1	563..616		2/4 (50%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	695..929		109/237 (46%)
		mRING-HC-C4C4_RBR_HOIP	697..750	CDD:438293	17/52 (33%)
		BRcat_RBR_HOIP	775..852	CDD:438998	33/76 (43%)
		Rcat_RBR_HOIP	853..937	CDD:439012	51/83 (61%)
		LDD domain	910..1072		54/161 (34%)
		E3_UbLigase_RBR	941..1032	CDD:436265	32/97 (33%)