DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and RNF216

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	NP_996994.1	Gene:	RNF216 / 54476	HGNCID:	21698	Length:	923	Species:	Homo sapiens

Alignment Length:	894	Identity:	179/894 - (20%)
Similarity:	310/894 - (34%)	Gaps:	243/894 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1953 DGQRAETKSPEDEVVILL-------DEESQMESSIAQSESNASLDSHSSESETSKVVLKEFVPSG 2010
            ||....:.|.::|.:.:|       .||..::..:..:|:|....|..:       ::|
Human    29 DGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTETNKPQRSRPN-------LIK------ 80

  Fly  2011 DPAK--QNLSELVEDTQRLIKQMRDEISMDE-----------FESTDEDEYSDEYSDEYDEGEE- 2061
             ||.  |:|..|.|:..   |:.|.....|:           |:|..:|:..|:|.:..|.|..
Human    81 -PAAQWQDLKRLGEERP---KKSRAAFESDKSSYFSVCNNPLFDSGAQDDSEDDYGEFLDLGPPG 141

  Fly  2062 -EEWYDSEGEEEGDFDGEEGNTYNEHASYIEEASTGDEGTEIEDIMEEDEDLADDDEPLQSQIPL 2125
             .|:....|:.|.  :.:.|.::|:.|:.|  .:...|...|  |:||...|..:.:||::|
Human   142 ISEFTKPSGQTER--EPKPGPSHNQAANDI--VNPRSEQKVI--ILEEGSLLYTESDPLETQ--- 197

  Fly  2126 DIEPVISPALSVTPTNQETDTIAHTEVVSSTGTRLETELPNPAMESILPSQSVQEDIKVEAIPIQ 2190
                           ||.::. :.||::|:.|          ...::...|:::||..::....|
Human   198 ---------------NQSSED-SETELLSNLG----------ESAALADDQAIEEDCWLDHPYFQ 236

  Fly  2191 S---APPIADSETRPAEQPVELVL-------EIPSEVEPTPVEEPTAL--PITPAP--PIVDSES 2241
            |   .|....::..|.|:..|..|       |.|....|.|..:...:  |.:|.|  |:.:.|.
Human   237 SLNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFED 301

  Fly  2242 RPVEPPVETVLEEPKKVTPSMKGKTANS----GTASKGPSTSSSTKTNKSTVSKIPKPTN----E 2298
            :.:....    |||....|..:.:..|.    |..:............|.|.::.|...|    |
Human   302 QQLASDD----EEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVANGFIEE 362

  Fly  2299 PTNKSNSTPL---------NKKVPLR--------SKSFSAPMGISSVKRI------------QEV 2334
            ..:..|...|         |...|.|        |.|..|....:.:.:|            |..
Human   363 IIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDYSKLTPLDQRC 427

  Fly  2335 YLQKQSSSIATSRV-----------PLKSS-PVTKKSINDAISRFNSNQADGPSTSGAAAAAAAA 2387
            ::|.....:|..:|           .||.. .:|:|:::|||.::   |...|.|||
Human   428 FIQAADLLMADFKVLSSQDIKWALHELKGHYAITRKALSDAIKKW---QELSPETSG-------- 481

  Fly  2388 LLKPRSQPRIPKKKYHETCFSDDDYETSATEEEQEEPNLAEPQK-AEQLKRKMSMPVFRAYPSVQ 2451
                   .|..:|:.::..:.|..:|....:.|:....|...:: .....|:..:|..:......
Human   482 -------KRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQEFY 539

  Fly  2452 EPVIEDPAILARKYVDQELVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAIAMLQQECEL 2516
            |..|::.|    ::.|..|...:.|.|         :.:|            .|.|     ||..
Human   540 EQKIKEMA----EHEDFLLALQMNEEQ---------YQKD------------GQLI-----ECRC 574

  Fly  2517 CMNSYPMNQMVSMLKC--LHKCCKQCAKSY-----FTVQITDRSINDCSCPFCKLPELSNEAQHE 2574
            |...:|..::.   :|  .|..||:|...|     |.....:.|..:.||. |..|.
Human   575 CYGEFPFEELT---QCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCT-CSFPT-------- 627

  Fly  2575 DEHLEYFSNLDIFLKSILDNDVHELFQRKLRDR--SLLQDPNFKWCIQCSSGFFARPKQKRLICP 2637
                   |.|:..|...:   :::.::||..:.  :...|...: |..||.........||..||
Human   628 -------SELEKVLPQTI---LYKYYERKAEEEVAAAYADELVR-CPSCSFPALLDSDVKRFSCP 681

  Fly  2638 D--CGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQNGI-DCPKCKFRYSL 2699
            :  |...||.:|:..| ::|.|.:||..    .|.|.......::|.:....| .|.||.... :
Human   682 NPHCRKETCRKCQGLW-KEHNGLTCEEL----AEKDDIKYRTSIEEKMTAARIRKCHKCGTGL-I 740

  Fly  2700 ARGGCMHFTCTQCKFEFCY-----------GCARPFMMGAKCTVSTYCA 2737
            ...||...:| :|..:.||           .|..|...||.|...:.|:
Human   741 KSEGCNRMSC-RCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	31/169 (18%)
		RING-HC_RNF169	2513..2563	CDD:319465	14/56 (25%)
		IBR	2598..2660	CDD:214763	17/65 (26%)
		IBR	<2690..2724	CDD:396187	10/44 (23%)
		E3_UbLigase_RBR	2760..2858	CDD:407926
RNF216	NP_996994.1	RING-HC_RBR_RNF216	570..626	CDD:319544	16/64 (25%)
		RING-HC finger (C3HC4-type)	572..621	CDD:319544	11/51 (22%)
		IBR	712..762	CDD:307574	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810