DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and arih2

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	NP_998308.1	Gene:	arih2 / 406417	ZFINID:	ZDB-GENE-040426-2158	Length:	492	Species:	Danio rerio

Alignment Length:	362	Identity:	84/362 - (23%)
Similarity:	130/362 - (35%)	Gaps:	108/362 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2407 FSDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKY------ 2465
            |.|||.:....:......||.|.                  .:|:||.  ||    .||
Zfish    16 FEDDDEDIGEGDIPHYYDNLEED------------------VAVEEPF--DP----EKYQFNCLT 56

  Fly  2466 ------VDQELVTNIAEA----QIAATLVSMKFSEDVALWAARECSDLDQAI------------- 2507
                  |..|.|.|:|.|    ...|.||.:.|...|.....|..|:..|.:
Zfish    57 YRESQRVLTEQVNNVASALKVSPAVAKLVLVHFHWQVVQILERYKSNSSQLLCEAYAQPTTTCRS 121

  Fly  2508 --AMLQQECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDR-------SINDCSCPFCK 2563
              |....:|.:|:.....:.::| |.|.|..||.|.:.:.||.:.|.       ...|||   .:
Zfish   122 LTAGTSLQCGVCLQLVRRDALLS-LPCQHSFCKGCWEQHCTVLVKDGVGVEISCMAQDCS---LR 182

  Fly  2564 LPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKL-RDRSLLQDPNFKWCIQCSSGF-- 2625
            :||                  |..|..:...::.:.::|.| ||   ..:.:|:  :|...|.
Zfish   183 MPE------------------DFVLPLLPSEELKDKYRRYLFRD---YVESHFQ--LQLCPGADC 224

  Fly  2626 -----FARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEW--KRENDPELQAQGVQEHL 2683
                 ...|:.:|:.|..|..|.|.:||:.:   |..:.|....:|  |..:|.|     ...::
Zfish   225 PIVIQVQEPRARRVQCSRCEEVFCFKCRQMY---HAPTDCATIRKWLTKCADDSE-----TANYI 281

  Fly  2684 AQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGC 2720
            :.:..|||||..... ..|||.|..|::||.:||:.|
Zfish   282 SAHTKDCPKCNICIE-KNGGCNHMQCSKCKHDFCWMC 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384
		RING-HC_RNF169	2513..2563	CDD:319465	15/56 (27%)
		IBR	2598..2660	CDD:214763	16/69 (23%)
		IBR	<2690..2724	CDD:396187	14/31 (45%)
		E3_UbLigase_RBR	2760..2858	CDD:407926
arih2	NP_998308.1	IBR	199..261	CDD:214763	16/69 (23%)
arih2	NP_998308.1	IBR	<289..321	CDD:279784	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810