DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and Arih2

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	NP_001012275.1	Gene:	Arih2 / 316005	RGDID:	1305839	Length:	492	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	81/353 - (22%)
Similarity:	135/353 - (38%)	Gaps:	80/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2408 SDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKYVD----- 2467
            :::||:.:..|||:||   .:|...|.....::..|.:......:|  |:.......|.:
  Rat    13 NEEDYDPNCEEEEEEE---EDPGDIEDYYVGVASDVEQQGADAFDP--EEYQFTCLTYKESEGAL 72

  Fly  2468 QELVTNIAEA----QIAATLVSMKFSEDVALWAARECSDLDQAI--AMLQ-------------QE 2513
            .|.:|::|.|    ...|.|:.:.|...|:....|..|:..|.:  |.:|             ..
  Rat    73 HEHMTSLASALKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHH 137

  Fly  2514 CELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSIN---DCSCPFCKL--------PEL 2567
            |.:||.......::| |.|.|:.|:.|.:.:.:|.:.| .:.   .|....|.|        |.|
  Rat   138 CAVCMQFVRKENLLS-LTCQHQFCRSCWEQHCSVLVKD-GVGVGISCMAQDCPLRTPEDFVFPLL 200

  Fly  2568 SNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFAR---P 2629
            .|| :..|::..|                  ||:..:.....||     .|.........|   |
  Rat   201 PNE-ELRDKYRRY------------------LFRDYVESHYQLQ-----LCPGADCPMVIRVQEP 241

  Fly  2630 KQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEW--KRENDPELQAQGVQEHLAQNGIDCPK 2692
            :.:|:.|..|..|.|.:||:.:   |..:.|....:|  |..:|.|     ...:::.:..||||
  Rat   242 RARRVQCNRCNEVFCFKCRQMY---HAPTDCATIRKWLTKCADDSE-----TANYISAHTKDCPK 298

  Fly  2693 CKFRYSLARGGCMHFTCTQCKFEFCYGC 2720
            |..... ..|||.|..|::||.:||:.|
  Rat   299 CNICIE-KNGGCNHMQCSKCKHDFCWMC 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384
		RING-HC_RNF169	2513..2563	CDD:319465	12/52 (23%)
		IBR	2598..2660	CDD:214763	15/64 (23%)
		IBR	<2690..2724	CDD:396187	14/31 (45%)
		E3_UbLigase_RBR	2760..2858	CDD:407926
Arih2	NP_001012275.1	RING-HC_RBR_TRIAD1	136..189	CDD:319687	13/54 (24%)
		IBR	207..269	CDD:214763	17/87 (20%)
		IBR	<297..329	CDD:396187	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810