Protein Alignment LUBEL and Arih2

DIOPT Version :10

• Sequence 1: NP_723214.2
• Gene: LUBEL / 33950
• FlyBaseID: FBgn0031857
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_001012275.1
• Gene: Arih2 / 316005
• RGDID: 1305839
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 353
• Identity: 81/353 - (22%)
• Similarity: 135/353 - (38%)
• Gaps: 80/353 - (22%)

  Fly  2408 SDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKYVD----- 2467
            :::||:.:..|||:||   .:|...|.....::..|.:......:|  |:.......|.:
  Rat    13 NEEDYDPNCEEEEEEE---EDPGDIEDYYVGVASDVEQQGADAFDP--EEYQFTCLTYKESEGAL 72

  Fly  2468 QELVTNIAEA----QIAATLVSMKFSEDVALWAARECSDLDQAI--AMLQ-------------QE 2513
            .|.:|::|.|    ...|.|:.:.|...|:....|..|:..|.:  |.:|             ..
  Rat    73 HEHMTSLASALKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHH 137

  Fly  2514 CELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSIN---DCSCPFCKL--------PEL 2567
            |.:||.......::| |.|.|:.|:.|.:.:.:|.:.| .:.   .|....|.|        |.|
  Rat   138 CAVCMQFVRKENLLS-LTCQHQFCRSCWEQHCSVLVKD-GVGVGISCMAQDCPLRTPEDFVFPLL 200

  Fly  2568 SNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFAR---P 2629
            .|| :..|::..|                  ||:..:.....||     .|.........|   |
  Rat   201 PNE-ELRDKYRRY------------------LFRDYVESHYQLQ-----LCPGADCPMVIRVQEP 241

  Fly  2630 KQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEW--KRENDPELQAQGVQEHLAQNGIDCPK 2692
            :.:|:.|..|..|.|.:||:.:   |..:.|....:|  |..:|.|     ...:::.:..||||
  Rat   242 RARRVQCNRCNEVFCFKCRQMY---HAPTDCATIRKWLTKCADDSE-----TANYISAHTKDCPK 298

  Fly  2693 CKFRYSLARGGCMHFTCTQCKFEFCYGC 2720
            |..... ..|||.|..|::||.:||:.|
  Rat   299 CNICIE-KNGGCNHMQCSKCKHDFCWMC 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Activator_LAG-3	<326..451	CDD:151935
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:465229
		PRK12323	<1291..>1402	CDD:481241
		rne	<1482..1771	CDD:236766
		Not5	<1647..>2001	CDD:444384
		DUF5585	<2138..>2378	CDD:465521
		DamX	<2154..>2254	CDD:442497
		mRING-HC-C4C4_RBR_HOIP	2512..2565	CDD:438293	14/63 (22%)
		BRcat_RBR_HOIP	2595..2671	CDD:438998	18/80 (23%)
		Rcat_RBR_HOIP	2672..2756	CDD:439012	16/49 (33%)
		E3_UbLigase_RBR	2760..2858	CDD:436265
Arih2	NP_001012275.1	RING-HC_RBR_TRIAD1	136..189	CDD:438429	13/54 (24%)
		BRcat_RBR_TRIAD1	216..287	CDD:439005	18/83 (22%)
		Rcat_RBR_TRIAD1	291..346	CDD:439021	15/36 (42%)
		Ariadne	351..>477	CDD:466073