DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and Rnf216

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	NP_001100592.1	Gene:	Rnf216 / 304294	RGDID:	1565135	Length:	910	Species:	Rattus norvegicus

Alignment Length:	908	Identity:	170/908 - (18%)
Similarity:	297/908 - (32%)	Gaps:	283/908 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1953 DGQRAETKSPEDEVVILL------DEESQMESSIAQSESNASLDSHSSESETSKVVLKEFVPSGD 2011
            :|....:.|.::|.:.:|      .:|..::..:..:|      :|..::....::        .
  Rat    29 EGPITISDSSDEEGIPMLVTPATEQQEDDLDDDVILTE------THKPQTSRPNLI--------K 79

  Fly  2012 PAK--QNLSELVEDTQRLIKQMRDEISMDEFESTDEDEYSDEYSDEYDEGEEEEWYDSEGEEEGD 2074
            ||.  |:|:.|.|:        |...|..:||:.....:|...:..:|.|.::   |||.|..|.
  Rat    80 PAAEWQDLNRLGEE--------RPRKSRADFEADTHSYFSFCNNSLFDSGAQD---DSEDECGGF 133

  Fly  2075 FD---GEEGNTYNEHASYIEEASTGDEGTEIED------------IMEEDEDLADDDEPLQSQIP 2124
            .|   .::|.          ||..|....:..|            |:.|:..|..:.|||:.|..
  Rat   134 LDLKTEKKGG----------EAKPGPSNKQTADNTVSPRLEQKVIILGENGLLFSESEPLEVQNQ 188

  Fly  2125 LDIEPVISPALSVTPTNQETDTIAHT-EVVSSTGTRLETE---LPNPAMESILPSQSVQEDIKVE 2185
            |.             .:.|||.:::. |..:|...:|..|   |.:|..:::.|....:.:
  Rat   189 LS-------------EDSETDLLSNPGEPAASVDEQLIEEEYWLDHPYFQALNPQPQERTN---- 236

  Fly  2186 AIPIQSAPPIADSETRPAEQPVELVLEIPSEVEPTPVEEPTALPITPAP--PI---------VDS 2239
                |..|....||:.............|:...|.|.:|....|.:|.|  |:         :|.
  Rat   237 ----QLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGPASPQPAHPLGELEDQQLAIDE 297

  Fly  2240 ESRPVEPPVETVLEEPKKVT-PSMKGKTANSGTASKGPSTSSSTKTNKSTVSKIPKPTN----EP 2299
            :..|..|     |..|::.. .::.|:.|..|.....|...      |.|.::.|...|    |.
  Rat   298 DPGPAYP-----LPGPQEANLANVWGQEAAEGDQELIPLLV------KETEARFPDVANGYVEEI 351

  Fly  2300 TNKSNSTPLN---------------------------------------------KKVPLRSKSF 2319
            .:..|...||                                             |..||..:.|
  Rat   352 IHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQDDVKLPKIDFFDYSKLTPLDQRCF 416

  Fly  2320 SAPMGISSVKRIQEVYLQKQSSSIATSRVPLKSS-PVTKKSINDAISRFNSNQADGPSTSGAAAA 2383
                 |.:...:...:....|..|..:...||.. .:|:|:.:|||.::   |...|.|||
  Rat   417 -----IQAADLLMADFKMLSSQDIKWALHELKGHYAITRKAFSDAIKKW---QELSPETSG---- 469

  Fly  2384 AAAALLKPRSQPRIPKKKYHETCFSDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYP 2448
                       .|..:|:.::..|.|..:         |:.|:       :::::|..
  Rat   470 -----------KRKKRKEMNQYSFIDFKF---------EQGNI-------KIEKRMFF------- 500

  Fly  2449 SVQEPVIEDPAILARKYVDQELVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAIAMLQQ- 2512
                  :|:.....|.|..|.|:..:.:.|        :|.|.    ..:|.::.:..:..||.
  Rat   501 ------LENKRRHCRSYDQQALLPAVQQEQ--------EFYEQ----KIKEMAEHEDFLLALQMN 547

  Fly  2513 -----------ECELCMNSYPMNQMVSMLKC--LHKCCKQCAKSYFTVQITDRSINDCSCP---- 2560
                       ||..|...:|..::.   :|  .|..||:|...|....:.....::.||.
  Rat   548 EEQYQKDGQLIECRCCYGEFPFEELT---QCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSC 609

  Fly  2561 FCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDR--SLLQDPNFKWCIQCSS 2623
            .|..|.               |.|:..|...:   :::.::||..:.  :...|...: |..||.
  Rat   610 TCSFPT---------------SELEKVLPQTI---LYKYYERKAEEEVAAAYADELVR-CPSCSF 655

  Fly  2624 GFFARPKQKRLICPD--CGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQN 2686
            ........||..||:  |...||.:|:..| ::|.|.:||..    .|.|.......::|.:...
  Rat   656 PALLDSDVKRFSCPNPRCRKETCRKCQGLW-KEHNGLTCEEL----AEKDDIKYRTSIEEKMTAA 715

  Fly  2687 GI-DCPKCKFRYSLARGGCMHFTCTQCKFEFCY-----------GCARPFMMGAKCTVSTYCA 2737
            .| .|.||.... :...||...:| :|..:.||           .|..|...||.|...:.|:
  Rat   716 RIRKCHKCGTGL-IKSEGCNRMSC-RCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCS 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	32/166 (19%)
		RING-HC_RNF169	2513..2563	CDD:319465	12/55 (22%)
		IBR	2598..2660	CDD:214763	17/65 (26%)
		IBR	<2690..2724	CDD:396187	10/44 (23%)
		E3_UbLigase_RBR	2760..2858	CDD:407926
Rnf216	NP_001100592.1	RING-HC_RBR_RNF216	558..614	CDD:319544	13/58 (22%)
Rnf216	NP_001100592.1	IBR	700..750	CDD:396187	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810