Protein Alignment LUBEL and Rnf216

DIOPT Version :10

• Sequence 1: NP_723214.2
• Gene: LUBEL / 33950
• FlyBaseID: FBgn0031857
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_001100592.1
• Gene: Rnf216 / 304294
• RGDID: 1565135
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 170/908 - (18%)
• Similarity: 297/908 - (32%)
• Gaps: 283/908 - (31%)

  Fly  1953 DGQRAETKSPEDEVVILL------DEESQMESSIAQSESNASLDSHSSESETSKVVLKEFVPSGD 2011
            :|....:.|.::|.:.:|      .:|..::..:..:|      :|..::....::        .
  Rat    29 EGPITISDSSDEEGIPMLVTPATEQQEDDLDDDVILTE------THKPQTSRPNLI--------K 79

  Fly  2012 PAK--QNLSELVEDTQRLIKQMRDEISMDEFESTDEDEYSDEYSDEYDEGEEEEWYDSEGEEEGD 2074
            ||.  |:|:.|.|:        |...|..:||:.....:|...:..:|.|.::   |||.|..|.
  Rat    80 PAAEWQDLNRLGEE--------RPRKSRADFEADTHSYFSFCNNSLFDSGAQD---DSEDECGGF 133

  Fly  2075 FD---GEEGNTYNEHASYIEEASTGDEGTEIED------------IMEEDEDLADDDEPLQSQIP 2124
            .|   .::|.          ||..|....:..|            |:.|:..|..:.|||:.|..
  Rat   134 LDLKTEKKGG----------EAKPGPSNKQTADNTVSPRLEQKVIILGENGLLFSESEPLEVQNQ 188

  Fly  2125 LDIEPVISPALSVTPTNQETDTIAHT-EVVSSTGTRLETE---LPNPAMESILPSQSVQEDIKVE 2185
            |.             .:.|||.:::. |..:|...:|..|   |.:|..:::.|....:.:
  Rat   189 LS-------------EDSETDLLSNPGEPAASVDEQLIEEEYWLDHPYFQALNPQPQERTN---- 236

  Fly  2186 AIPIQSAPPIADSETRPAEQPVELVLEIPSEVEPTPVEEPTALPITPAP--PI---------VDS 2239
                |..|....||:.............|:...|.|.:|....|.:|.|  |:         :|.
  Rat   237 ----QLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGPASPQPAHPLGELEDQQLAIDE 297

  Fly  2240 ESRPVEPPVETVLEEPKKVT-PSMKGKTANSGTASKGPSTSSSTKTNKSTVSKIPKPTN----EP 2299
            :..|..|     |..|::.. .::.|:.|..|.....|...      |.|.::.|...|    |.
  Rat   298 DPGPAYP-----LPGPQEANLANVWGQEAAEGDQELIPLLV------KETEARFPDVANGYVEEI 351

  Fly  2300 TNKSNSTPLN---------------------------------------------KKVPLRSKSF 2319
            .:..|...||                                             |..||..:.|
  Rat   352 IHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQDDVKLPKIDFFDYSKLTPLDQRCF 416

  Fly  2320 SAPMGISSVKRIQEVYLQKQSSSIATSRVPLKSS-PVTKKSINDAISRFNSNQADGPSTSGAAAA 2383
                 |.:...:...:....|..|..:...||.. .:|:|:.:|||.::   |...|.|||
  Rat   417 -----IQAADLLMADFKMLSSQDIKWALHELKGHYAITRKAFSDAIKKW---QELSPETSG---- 469

  Fly  2384 AAAALLKPRSQPRIPKKKYHETCFSDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYP 2448
                       .|..:|:.::..|.|..:         |:.|:       :::::|..
  Rat   470 -----------KRKKRKEMNQYSFIDFKF---------EQGNI-------KIEKRMFF------- 500

  Fly  2449 SVQEPVIEDPAILARKYVDQELVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAIAMLQQ- 2512
                  :|:.....|.|..|.|:..:.:.|        :|.|.    ..:|.::.:..:..||.
  Rat   501 ------LENKRRHCRSYDQQALLPAVQQEQ--------EFYEQ----KIKEMAEHEDFLLALQMN 547

  Fly  2513 -----------ECELCMNSYPMNQMVSMLKC--LHKCCKQCAKSYFTVQITDRSINDCSCP---- 2560
                       ||..|...:|..::.   :|  .|..||:|...|....:.....::.||.
  Rat   548 EEQYQKDGQLIECRCCYGEFPFEELT---QCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSC 609

  Fly  2561 FCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDR--SLLQDPNFKWCIQCSS 2623
            .|..|.               |.|:..|...:   :::.::||..:.  :...|...: |..||.
  Rat   610 TCSFPT---------------SELEKVLPQTI---LYKYYERKAEEEVAAAYADELVR-CPSCSF 655

  Fly  2624 GFFARPKQKRLICPD--CGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQN 2686
            ........||..||:  |...||.:|:..| ::|.|.:||..    .|.|.......::|.:...
  Rat   656 PALLDSDVKRFSCPNPRCRKETCRKCQGLW-KEHNGLTCEEL----AEKDDIKYRTSIEEKMTAA 715

  Fly  2687 GI-DCPKCKFRYSLARGGCMHFTCTQCKFEFCY-----------GCARPFMMGAKCTVSTYCA 2737
            .| .|.||.... :...||...:| :|..:.||           .|..|...||.|...:.|:
  Rat   716 RIRKCHKCGTGL-IKSEGCNRMSC-RCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCS 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Activator_LAG-3	<326..451	CDD:151935
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:465229
		PRK12323	<1291..>1402	CDD:481241
		rne	<1482..1771	CDD:236766
		Not5	<1647..>2001	CDD:444384	7/53 (13%)
		DUF5585	<2138..>2378	CDD:465521	55/305 (18%)
		DamX	<2154..>2254	CDD:442497	22/113 (19%)
		mRING-HC-C4C4_RBR_HOIP	2512..2565	CDD:438293	13/70 (19%)
		BRcat_RBR_HOIP	2595..2671	CDD:438998	20/79 (25%)
		Rcat_RBR_HOIP	2672..2756	CDD:439012	17/78 (22%)
		E3_UbLigase_RBR	2760..2858	CDD:436265
Rnf216	NP_001100592.1	RING-HC_RBR_RNF216	558..614	CDD:438292	13/58 (22%)
		BRcat_RBR_RNF216	647..698	CDD:439000	16/56 (29%)
		Rcat_RBR_RNF216	709..765	CDD:439014	13/57 (23%)