Protein Alignment LUBEL and Arih2

DIOPT Version :10

• Sequence 1: NP_723214.2
• Gene: LUBEL / 33950
• FlyBaseID: FBgn0031857
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_035920.1
• Gene: Arih2 / 23807
• MGIID: 1344361
• Length: 492
• Species: Mus musculus
• Alignment Length: 353
• Identity: 79/353 - (22%)
• Similarity: 134/353 - (37%)
• Gaps: 80/353 - (22%)

  Fly  2408 SDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKYVDQE--- 2469
            :::||:.:..|||:||   .:|...|.....::..|.:......:|  |:.......|.:.|
Mouse    13 NEEDYDPNCEEEEEEE---EDPGDIEDYYVGVASDVEQQGADAFDP--EEYQFTCLTYKESEGAL 72

  Fly  2470 ------LVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAI--AMLQ-------------QE 2513
                  |.:.:..:...|.|:.:.|...|:....|..|:..|.:  |.:|             ..
Mouse    73 HEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHH 137

  Fly  2514 CELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSIN---DCSCPFCKL--------PEL 2567
            |.:||.......::| |.|.|:.|:.|.:.:.:|.:.| .:.   .|....|.|        |.|
Mouse   138 CAVCMQFVRKENLLS-LACQHQFCRSCWEQHCSVLVKD-GVGVGISCMAQDCPLRTPEDFVFPLL 200

  Fly  2568 SNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFAR---P 2629
            .|| :..|::..|          :..:.|...||.:|             |.........|   |
Mouse   201 PNE-ELRDKYRRY----------LFRDYVESHFQLQL-------------CPGADCPMVIRVQEP 241

  Fly  2630 KQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEW--KRENDPELQAQGVQEHLAQNGIDCPK 2692
            :.:|:.|..|..|.|.:||:.:   |..:.|....:|  |..:|.|     ...:::.:..||||
Mouse   242 RARRVQCNRCSEVFCFKCRQMY---HAPTDCATIRKWLTKCADDSE-----TANYISAHTKDCPK 298

  Fly  2693 CKFRYSLARGGCMHFTCTQCKFEFCYGC 2720
            |..... ..|||.|..|::||.:||:.|
Mouse   299 CNICIE-KNGGCNHMQCSKCKHDFCWMC 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Activator_LAG-3	<326..451	CDD:151935
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:465229
		PRK12323	<1291..>1402	CDD:481241
		rne	<1482..1771	CDD:236766
		Not5	<1647..>2001	CDD:444384
		DUF5585	<2138..>2378	CDD:465521
		DamX	<2154..>2254	CDD:442497
		mRING-HC-C4C4_RBR_HOIP	2512..2565	CDD:438293	14/63 (22%)
		BRcat_RBR_HOIP	2595..2671	CDD:438998	18/80 (23%)
		Rcat_RBR_HOIP	2672..2756	CDD:439012	16/49 (33%)
		E3_UbLigase_RBR	2760..2858	CDD:436265
Arih2	NP_035920.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		9/26 (35%)
		UBA-like. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	64..111		8/46 (17%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	134..343		55/227 (24%)
		RING-HC_RBR_TRIAD1	136..189	CDD:438429	13/54 (24%)
		BRcat_RBR_TRIAD1	216..287	CDD:439005	20/91 (22%)
		Rcat_RBR_TRIAD1	291..346	CDD:439021	15/36 (42%)
		Ariadne	351..>477	CDD:466073
		Ariadne domain. /evidence=ECO:0000250|UniProtKB:Q9Y4X5	358..492