DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and LOC100334178

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	XP_009296840.2	Gene:	LOC100334178 / 100334178	-ID:	-	Length:	1052	Species:	Danio rerio

Alignment Length:	961	Identity:	264/961 - (27%)
Similarity:	389/961 - (40%)	Gaps:	278/961 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2106 MEEDEDLADD---------------DEPLQSQIPLDIEPVISPALSVT---PTNQ---------- 2142
            ::|:|.|:.|               ..||.|  |...:...|||||::   |:.|
Zfish   185 VQEEEGLSTDAVVFAPSEKVWDKQTPSPLSS--PPQAKSPFSPALSLSSLAPSTQTENCTICGIF 247

  Fly  2143 ---------------ETDTIAHTE----------VVSSTGT-RLETEL----------------- 2164
                           |.|.:.|:.          |.||..| ||.:.|
Zfish   248 PVSAHCPTCTQKLCTECDRLYHSHSGRSTHIRIPVTSSRPTKRLSSSLSTWQCSYCTTVNSMLQV 312

  Fly  2165 -----PNPAMESILPSQSVQEDIKVEAIPIQSAPPIADSE------------------------- 2199
                 ..|.:.|..|  |:||         :|:.|...||
Zfish   313 LCETCDRPRLSSAAP--SLQE---------ESSQPSTISEWQCKSCTVVNAGSSILCEVCERPRL 366

  Fly  2200 -TRPAEQP-------------------VELVLEIPSEV-------EPTPVEEPT-ALPITPA--- 2233
             |||...|                   ...|...||.|       .|.|...|: .||::|.
Zfish   367 ATRPPAVPPRATPSSSALMDSQWICQFCTYVNRTPSTVCDMCCLSRPEPSISPSKPLPLSPVKDL 431

  Fly  2234 -PPIVDSESRPVEPP---------------VETVLE------EPKKVTPSMKGKTANSGTASKGP 2276
             ||...:::.|.|.|               ::.:.|      .|::|..||:    .||.::..|
Zfish   432 LPPAATTKATPTEDPDLKRQRLMKEDGLKLIQLIREGEKKGVSPEEVYTSMR----VSGNSNVTP 492

  Fly  2277 STSSSTKTNK-------STVSKIPKPTNEPTN------KSNSTPLNKKVPLRSKSFSAPMGISSV 2328
            .....|:...       ...|...:|.....|      |.|..||::   ..:|......|..:.
Zfish   493 YDWLKTELPHVLDEICVMAASCQQEPNGSGGNNGHDGLKGNPVPLSR---AEAKRAWLAAGGDNE 554

  Fly  2329 KRIQEVYLQKQSSSIATSRVPLKSSPVTKKSINDAISRFNSNQADGPSTSGAAAAAAAALLKPRS 2393
            |.:::        ::...||.:|.  :.....|||.....:.:..|....||.......||:|
Zfish   555 KAVRQ--------ALRDRRVKVKE--LGSLGFNDATRCEEALRQSGGDVRGALVLLQRPLLEP-- 607

  Fly  2394 QPRIPKKKYHETCFSDDDYETSATEEEQEEP-NLAEPQKAEQLKRKMS---MPVFRAYPSVQEPV 2454
                    :|:..:|          ||.|.| ::..|.|....:|.::   :|.:.....:.. :
Zfish   608 --------FHQRMWS----------EEPEPPIDINHPDKQHVCRRLLAVFDLPSWGRCELILS-L 653

  Fly  2455 IEDPAILARKYVDQELVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAIAMLQQECELCMN 2519
            :.||   |..|                ||      ||| :.|.||..|.|....:|.:||.:|::
Zfish   654 LRDP---AANY----------------TL------EDV-VQAVRESPDRDFIRRVLNKECPICLS 692

  Fly  2520 SYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHL-EYFSN 2583
            .:|.::|.|:..|....|..|.:.:||:.:.|:.|.|..||.|..|::     ::.||| .|||.
Zfish   693 VFPHSKMRSLTSCQCSVCCGCFQQHFTIAVRDKHIRDMVCPVCTEPDI-----NDPEHLNSYFST 752

  Fly  2584 LDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCR 2648
            |||.|:..|:.:|:|||.:||.:::|::||.|.||..||.||.....|.::.|..|....||||:
Zfish   753 LDIQLRDCLEQEVYELFHKKLTEQALIKDPKFLWCSHCSYGFIYDDDQLKVTCSQCRKSFCAQCK 817

  Fly  2649 KPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCK 2713
            |.||.||.|.|||.:..||||||||.|.||:..:|..|||.||.|:|:|:|||||||||:|:||:
Zfish   818 KTWEPQHMGLSCEQFQLWKRENDPEYQRQGLAGYLRDNGITCPNCRFQYALARGGCMHFSCSQCR 882

  Fly  2714 FEFCYGCARPFMMGAKCTVSTYCAKLGLHAHHPRNCLFYLRDKIPLQLQFLLKEQNVKFDTEPMQ 2778
            ::||.||..||  ...|.|: .|...||||||||:|||||||..|.:||.||:::.|.::||
Zfish   883 YQFCSGCNNPF--HTTCAVN-QCTVTGLHAHHPRDCLFYLRDWEPARLQALLQKKGVNYNTE--- 941

  Fly  2779 IKDESSSSSKARAQARCPIPLQKETPQGLVDTVCNTEVPDKHAGMCRTHYVEYLAGKVAKAGIDP 2843
                   ::.......|.:..||:......|:.|..:.....||:|..||.|||...:....|||
Zfish   942 -------TAPGAQTGVCGVIEQKDEGPRPTDSPCGAQTQPGQAGLCDKHYREYLVSLINGHSIDP 999

  Fly  2844 LPIFDLTDCVQELRRR--GIALPERGPWDTDEIYKNMCSEVIKK---HIPL 2889
            ..:|.:.:.....||.  .|.|.:|    .||  :...|.::||   .:||
Zfish  1000 ALLFTMDELTVACRRYHVDITLLDR----EDE--QTHFSRLLKKLMDDVPL 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	46/260 (18%)
		RING-HC_RNF169	2513..2563	CDD:319465	16/49 (33%)
		IBR	2598..2660	CDD:214763	28/61 (46%)
		IBR	<2690..2724	CDD:396187	21/33 (64%)
		E3_UbLigase_RBR	2760..2858	CDD:407926	24/97 (25%)
LOC100334178	XP_009296840.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1812
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006359
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106001
Panther	1	1.100	-	-	LDO	PTHR16004
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.740