DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LUBEL and rnf31

DIOPT Version :9

Sequence 1:	NP_723214.2	Gene:	LUBEL / 33950	FlyBaseID:	FBgn0031857	Length:	2892	Species:	Drosophila melanogaster
Sequence 2:	XP_031755534.1	Gene:	rnf31 / 100036616	XenbaseID:	XB-GENE-968731	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	935	Identity:	261/935 - (27%)
Similarity:	383/935 - (40%)	Gaps:	209/935 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2128 EPVISPALSVTPTNQETDT-IAHTE---VVSSTGTRLETELPNPAMESILPSQSVQEDIKVEAIP 2188
            ||.:|...:||     .|. |.|.|   ::|:...|.| |.....:...||.||:..|
Frog   136 EPDVSTVAAVT-----ADVIILHHELNLLISNMHPRHE-EAAQELLGGELPQQSLVAD------- 187

  Fly  2189 IQSAPPIADSETRPA------------------EQPVELVLEIPSEVEPTPVE-EPTALPI--TP 2232
            ..|||.....||..|                  |...|   |........||. :...||.  |.
Frog   188 YVSAPKDPQPETTSAGCFLCGTLVCSVFCSSCNEMLCE---ECDKRAHSHPVRAQHVRLPCGNTA 249

  Fly  2233 APPIVDSESRPV---EPP---------------VETVLEEPKKVTPSMKGKTANSGTASKGPSTS 2279
            .|..:|.:|...   .||               :..|.|.|:..|.|:...:..|..........
Frog   250 KPRSLDQDSPSTVSSRPPWRCYSCHFENKGGSVLCVVCERPRGCTSSLSNLSLGSTLQRDSWECQ 314

  Fly  2280 SSTKTNKST-----VSKIPKPTNEPTNKSNSTP--LNKKVPLRSKSFSAPM----GISSVKRIQE 2333
            :.|..|.::     |...|:..::|......:.  |.:.:...:||.:.|:    |:.::|..||
Frog   315 ACTLQNSASAVLCAVCDRPRLASKPAQDGYDSVALLLRDIQRDNKSITCPVSEKNGLFAMKNHQE 379

  Fly  2334 VYLQKQSSSIATSRVPLKSSPVTKKSINDA-------ISRFNSNQ------ADGPSTSGAAAAAA 2385
            ...:.:|..      ||......::.|..:       .:.||:..      .|..|...||....
Frog   380 SMHEPESIG------PLIDHTRQEEEIAKSEGWQCSHCTFFNTRNGRVCEICDRTSEGTAATEQP 438

  Fly  2386 AALLKPRSQPRIPKK-----------------KY----HETCFSDDDYETSATEEEQ-----EEP 2424
            .||.....|..|.:|                 ||    .|.|.:   ...|.||..|     |.|
Frog   439 KALDMAHVQEEIRQKRLREDGAKIVALIREGEKYGVLPEEVCSA---IRYSGTEVPQWWLQTELP 500

  Fly  2425 NLAE------PQKA-------------------------------EQLKRK------MSMP---- 2442
            .:.|      .|||                               .:.:||      :..|
Frog   501 YVLERLLDAASQKAGDTIGALTVEEARDAWVSSGGDMDAAVILCVTERRRKVDALSGLGFPERHK 565

  Fly  2443 -----------VFRAYPSVQEPVIE-------------------DPAILARKYVDQELVTNIAEA 2477
                       |.||...:|.|::|                   |...:.|:.:.:..:.:...|
Frog   566 VVAALYESAGDVGRALSILQRPLLEPFLIRMWEEPQPPLRLDSADRQAVLRRLLAEHSLHSWGRA 630

  Fly  2478 QIAATLV---SMKFSEDVALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCLHKCCKQ 2539
            ::|.:|:   ..::.....:.|.||..|.|....||.|||.:|....|.|:|.|:..|....|..
Frog   631 ELALSLLIEGEGRYELQDVVEAVRESQDRDFIKRMLTQECAVCGWELPRNKMRSLTSCECCICPD 695

  Fly  2540 CAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKL 2604
            |.:.:|||.:.::.|.|..||.|:.||:|:|.    |.|.|||.|||.|:..|:.|.::||.:||
Frog   696 CFRMHFTVAVKEKHIRDMICPACEEPEISDEG----ELLHYFSTLDILLRDTLEVDAYDLFHKKL 756

  Fly  2605 RDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEWKRE 2669
            .:|:|::||.|.||..||.||.....|..:.||.|....|.:|::|||.||...:|:.:..||||
Frog   757 TERTLMKDPKFLWCTHCSFGFIYERDQLDVKCPQCQCSFCRKCKRPWEEQHRSLNCDDFQNWKRE 821

  Fly  2670 NDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCARPFMMGAKCTVST 2734
            ||.|.||||:..:|.:|||.||.|||.|:|||||||||.|:||:.:||.||...|....||||.:
Frog   822 NDAEYQAQGLAVYLLENGITCPHCKFSYALARGGCMHFICSQCRHQFCSGCYNTFHQRNKCTVPS 886

  Fly  2735 YCAKLGLHAHHPRNCLFYLRDKIPLQLQFLLKEQNVKFDTEPMQIKDESSSSSKARAQARCPIPL 2799
            ...::.|||||||:|||||||....:||.||:...|:|:|:|       .:.::......|.:..
Frog   887 CTVRMSLHAHHPRDCLFYLRDWDVTRLQRLLQMLLVQFNTDP-------PAGTQTAPGGGCRVME 944

  Fly  2800 QKETPQGLVDTVCNTEVPDKHAGMCRTHYVEYLAGKVAKAGIDPLPIFDLTDCVQELRRRGIALP 2864
            |||.|.||.|..|....|..:||:|.:||.|||..::....:||..::||.:.:...:|....||
Frog   945 QKEIPDGLRDEACGKITPPGYAGLCESHYKEYLVSRINAHSLDPCVLYDLAETMNVCQRYLPVLP 1009

  Fly  2865 ERGPWDTDEIYKNMCSEVIKKHIPL 2889
            .:.|.:.:..|:.....|:...:||
Frog  1010 LQDPTEDEASYRERLLGVLISEVPL 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUBEL	NP_723214.2	Bbox1_HOIP	89..132	CDD:380873
		Med15	<336..>483	CDD:312941
		ZnF_RBZ	737..761	CDD:197784
		RanBP2-type Zn finger	738..757	CDD:275376
		HOIP-UBA	1036..1184	CDD:406963
		PRK01741	1199..>1402	CDD:234977
		rne	<1482..1771	CDD:236766
		Streccoc_I_II	<2159..>2307	CDD:411384	38/191 (20%)
		RING-HC_RNF169	2513..2563	CDD:319465	17/49 (35%)
		IBR	2598..2660	CDD:214763	26/61 (43%)
		IBR	<2690..2724	CDD:396187	22/33 (67%)
		E3_UbLigase_RBR	2760..2858	CDD:407926	30/97 (31%)
rnf31	XP_031755534.1	PUB_RNF31	51..159	CDD:198422	9/27 (33%)
		Bbox1_HOIP	204..245	CDD:380873	6/43 (14%)
		RanBP2-type Zn finger	268..287	CDD:275376	0/18 (0%)
		zf-RanBP	309..334	CDD:395516	3/24 (13%)
		RanBP2-type Zn finger	311..330	CDD:275376	2/18 (11%)
		RanBP2-type Zn finger	406..425	CDD:275376	2/18 (11%)
		HOIP-UBA	454..599	CDD:406963	23/147 (16%)
		mRING-HC-C4C4_RBR_HOIP	669..721	CDD:319545	18/51 (35%)
		IBR	750..803	CDD:396187	21/52 (40%)
		E3_UbLigase_RBR	922..1003	CDD:407926	26/87 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006359
OrthoInspector	1	1.000	-	-		oto103902
Panther	1	1.100	-	-	LDO	PTHR16004
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5187
SonicParanoid	1	1.000	-	-		X6141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.040