Protein Alignment TTLL3A and TTLL4

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: XP_016860876.1
• Gene: TTLL4 / 9654
• HGNCID: 28976
• Length: 1226
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 206/1052 - (19%)
• Similarity: 347/1052 - (32%)
• Gaps: 337/1052 - (32%)

  Fly    26 PQKCASATLAKKPVTPPAAPP-------------PTPSNRVVAPLTVPVIQLTPAQSDSPVKLAR 77
            |......|...|||:||...|             |.|.:..| |.::..:   ||.:.:.:.|:.
Human   229 PVPLLQTTQGLKPVSPPKIQPVSWHHSGGTGDCAPQPVDHKV-PKSIGTV---PADASAHIALST 289

  Fly    78 PATPKETAISVPDH-SNKENQPARTPPPSKSCPLG------APTNYVARRTWITTERMNELRRKA 135
            .::...:..||... .|:.|...|..|  .||.|.      .||..:.     .||.:.:|..:.
Human   290 ASSHDTSTTSVASSWYNRNNLAMRAEP--LSCALDDSSDSQDPTKEIR-----FTEAVRKLTARG 347

  Fly   136 QEAAKQNKIFTIRGC---FNSVRNALLMRGWVEKLDVHRKVMPAGQMTYEDLTQRLPKRKAGETR 197
            .|...:      :||   .:|..|....  | ..|:..|:..|..      :.|:.|:..||..|
Human   348 FEKMPR------QGCQLEQSSFLNPSFQ--W-NVLNRSRRWKPPA------VNQQFPQEDAGSVR 397

  Fly   198 R-----------QYVQKCERNIMSRFL-EHMPVDFLWTNRKEKCDYI------DQAKNPGMTINK 244
            |           .....|.:.|....| .|..    ..|....|:.:      .:.|.||
Human   398 RVLPGASDTLGLDNTVFCTKRISIHLLASHAS----GLNHNPACESVIDSSAFGEGKAPG----- 453

  Fly   245 FHRAPFTSKEGL----------------------------------------------------- 256
               .||....|:
Human   454 ---PPFPQTLGIANVATRLSSIQLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEEL 515

  Fly   257 -------CSQLRDFHWFFEEGTAEMYFPRC--YNVWSPEELGEFIENFKLTACVAFLRAMLCKYH 312
                   ||:..:..   |||.:|     |  .:..||.|....|..    :|:..|...|..:.
Human   516 VDGLEDCCSRDENEE---EEGDSE-----CSSLSAVSPSESVAMISR----SCMEILTKPLSNHE 568

  Fly   313 KQGSDA-VFSCSGKIP-----------YSAIDFAYKRLVEYIDS------------------CQH 347
            |....| ::|....:|           ...:.:..::|:.:..|                  .:.
Human   569 KVVRPALIYSLFPNVPPTIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKR 633

  Fly   348 NDIDFEDPPKIWEHDWDAFLF----QHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDK------- 401
            ||    |....|.|...:..|    :||:|.:..|..|.....||...:....|...|
Human   634 ND----DWLGCWGHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFP 694

  Fly   402 -----------MKVHWPQYSLDGYQNMWIVKPANKCRGRGIILMDNLKKILGVVNLSIASKSRYV 455
                       ::..|...|    :..|||||....||.||.::....:        :..:...:
Human   695 QSFILPQDAKLLRKAWESSS----RQKWIVKPPASARGIGIQVIHKWSQ--------LPKRRPLL 747

  Fly   456 VQKYIERPLILFQTKFDIRQWFLITNTQPLVVWFYRESYLRFSSQEYSLSNH---HESVHLTNYA 517
            ||:|:.:|.::..:|||:|.:..:|:..||.::.:.:..:||:|.:||.|..   ::.:|||||:
Human   748 VQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYS 812

  Fly   518 IQKKYT--NGKRDKRLPSENMWDCYSFQAYLRQIGKYNMWLERIFPGMRKAIVGCMLASQENMD- 579
            :.||..  ....|:.....:.|...:...||.|.|..:   :.|:..::..:|..:::|:..:.
Human   813 VNKKNAEYQANADEMACQGHKWALKALWNYLSQKGVNS---DAIWEKIKDVVVKTIISSEPYVTS 874

  Fly   580 ------RRP-NTFELFGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCLEDVVKV---VI 634
                  ||| :..||||.|.|:.||..||::|:|.||.|.:::.:...:..|.:.|::.:   |:
Human   875 LLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVL 939

  Fly   635 DRRTD---------------PKAELGNFELAYRQVVPPTPAYMGLNLFVKGKQVLQKANHGGGHG 684
            ....|               |.:......:|...|.               .|.::||
Human   940 PNAEDIISSPSSCSSSTTSLPTSPGDKCRMAPEHVT---------------AQKMKKA------- 982

  Fly   685 HYYYQQQRKERSLATSSV-----------------YRQRSAI--IHPATSISRIHRAMPT---FN 727
             ||..|:..::....|.:                 :.:|...  |.|:...||..|....   ||
Human   983 -YYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSRYLRFFEQPRYFN 1046

  Fly   728 --ATEYMEKYMVEPLS--SSRSSLCSQ------LPQKSP--SAAPALTATPSGATSSYILKQAGR 780
              .|::.:||....|.  ....|.|.:      :...:|  |||....::.||.:...::..||.
Human  1047 ILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVVSAASVEDSSFSGPSLLCLMSAAGV 1111

  Fly   781 SITQL-------------LSATHKRNTG--GSLSGEQVQ-------STALPPKRQRSCGP---RL 820
            .:..|             |:|..|..|.  |..|..:|.       :|....|.|....|   :.
Human  1112 GLWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQAGLSPYPQKP 1176

  Fly   821 SSTNPVESTEKK 832
            ||:...|.|.|:
Human  1177 SSSKDSEDTSKE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	82/368 (22%)
TTLL4	XP_016860876.1	TTL	654..946	CDD:397308	75/306 (25%)