Protein Alignment TTLL3A and TTLL6

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: NP_001124390.1
• Gene: TTLL6 / 284076
• HGNCID: 26664
• Length: 891
• Species: Homo sapiens
• Alignment Length: 768
• Identity: 169/768 - (22%)
• Similarity: 283/768 - (36%)
• Gaps: 175/768 - (22%)

  Fly   265 WFFEEGTAE-MYFPRCYNVWS-----PEELGEFI-ENFKLTACVAFLRAM------LCKYHKQGS 316
            |:|...::: ...|:|..:.|     .||.|:.. |:.|.|..:||:|..      |....:||.
Human    37 WYFPRASSQAREMPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGK 101

  Fly   317 DAVFSCSGKIPYSAIDFAYKRLVEYIDSCQHNDI-----------DFEDPPKIWEHDWDAFLFQH 370
            .              ....||||..:.||::..:           ..||..  |...|..:....
Human   102 K--------------KRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDD--WTLYWTDYSVSL 150

  Fly   371 QQLVNEDG--RIQHDGG-----------QRLEPMVKS------------CLSLVDKMKVHW---P 407
            ::::....  :|.|..|           :.:..|:|.            ||      ...|   .
Human   151 ERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCL------PADWGDLQ 209

  Fly   408 QYSLDGYQNMWIVKPANKCRGRGIILMDNLKKILGVVNLSIASKSRYVVQKYIERPLILFQTKFD 472
            .||.......:|.||.:.|:|:||.:...:|:|....::        :.|.||.:|.|:...|||
Human   210 TYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDM--------ICQLYISKPFIIDGFKFD 266

  Fly   473 IRQWFLITNTQPLVVWFYRESYLRFSSQEYS--LSNHHESV--HLTNYAIQKKYTNGKRDKRLPS 533
            :|.:.|:|:..||.::.|.|...||::..||  .:::.:.:  |||||:|.|..:|..||....|
Human   267 LRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGS 331

  Fly   534 ENMWDCYSFQAYLRQIGKYNMWLERIFPGMRKAIVGCMLASQENMDRRPNT-----------FEL 587
            :....  :|.|||.. ..||  :|:|:..:...|:..::::...:....:|           ||:
Human   332 KRKLS--TFSAYLED-HSYN--VEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEI 391

  Fly   588 FGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCLEDVVKVVIDRRTDPKAEL------GN 646
            .|.|.::.....|||:|:|.||.....:.:...:....|.|.:.::.....|.|..|      |.
Human   392 LGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQ 456

  Fly   647 F--ELAYRQV-VPPTPAYMGLNLFVKGKQVLQKANHGGGHGHY-------YYQQQRKERSLATSS 701
            |  :...|:: :.....:..:.|  |..:..:|.|.||....|       |.:..:...||..::
Human   457 FLQQCCSREMRIEEAKGFRAVQL--KKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNT 519

  Fly   702 V-YRQRSAIIHPATSISRIHRAMPTFNATEYMEKYMVEPLSSSRSSLCSQLPQKSPSAAPALTAT 765
            | .|.|...........|:.|....|...:.:|..........|........||......|.|.
Human   520 VASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQ- 583

  Fly   766 PSGATSSYILKQAGRSITQ--LLS--ATHKRNTGGSLSGEQVQSTALPPKRQRSCGPRLSSTNPV 826
               |:..||......|.|.  |||  ...|..|..||:.|      .|.:...|..|:|:|..|.
Human   584 ---ASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQE------APTEEASSVFPKLTSAKPF 639

  Fly   827 ESTEKKFKILIKNYSSNGNENMQDARP----EVANSATATAISERKWRSLRNIAATAGGSSNLAA 887
            .|......|   |.||:   .::.::|    :.|.||:|..:...... |.::..|...::.|:.
Human   640 SSLPDLRNI---NLSSS---KLEPSKPNFSIKEAKSASAVNVFTGTVH-LTSVETTPESTTQLSI 697

  Fly   888 RSKGPPLIA-------------------------PPSLPTRRLTR----TKSE 911
            ..|.||.:|                         ||.|..:::.:    |||:
Human   698 SPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSK 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	78/351 (22%)
TTLL6	NP_001124390.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..106		15/75 (20%)
		TTL	154..441	CDD:397308	72/305 (24%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	420..499		15/80 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	546..584		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..636		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..711		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..820