Protein Alignment TTLL3A and TTLL3

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: NP_001021100.3
• Gene: TTLL3 / 26140
• HGNCID: 24483
• Length: 915
• Species: Homo sapiens
• Alignment Length: 953
• Identity: 280/953 - (29%)
• Similarity: 407/953 - (42%)
• Gaps: 204/953 - (21%)

  Fly    37 KPVTPPAAPPPTPSNRVVAPLTVPVIQLTPAQSD-----------SPVKLAR---------PATP 81
            :|:.|..:.|....:....|..:|......|||:           ||....|         |.|.
Human    41 QPLEPRTSFPSARRSEFRPPRRLPWAGPASAQSEEGHAGGRCQAGSPAPARRLSGAFKTLVPGTH 105

  Fly    82 KETAISV----PDHSNKENQPARTPPPSKSCPLGAPTNYVARRTWITTERMNELRRK---AQEAA 139
            .:.|...    |.|:     |...|.|....|       |..|.......||.||..   .:.|.
Human   106 AQGASDTHPLGPPHT-----PVLDPSPQDGFP-------VLWRGSSKASHMNRLRNAKIYVERAV 158

  Fly   140 KQNKIFTIRGCFNSVRNALLMRGWVEKLDVHR---------KVMPAGQMTYEDLTQRLPKRKAGE 195
            ||.|||||:||:..:|..|..||||||..|||         |.:.:..|...|.|:...:.:..|
Human   159 KQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEE 223

  Fly   196 TRRQYVQKCERNIMSRFLEHMPVDFLWTNRKEKCDYIDQAKNPGMTINKFHRAPFTSKEGLCSQL 260
                            |......||   :...|.|.:|              .......|||..|
Human   224 ----------------FQPSQLFDF---DDLLKFDDLD--------------GTHALMVGLCLNL 255

  Fly   261 RDFHWFFEEGTAEMYFPRCYNVWSPEELGEFIENFKLTACVAFLRAML----------------- 308
            |:..| |:|..|..:|||||.:.:.::...|||:|.|||....|:.::
Human   256 RNLPW-FDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEAS 319

  Fly   309 --CKYHKQGSDAVFSCSGKIPYSAIDFAYKRLVEYIDSCQHNDI--DFEDPPKIWEHDWDAFLFQ 369
              .:..||..:.|.     :....:|.|.....||:.:..|.||  |.|.|..:....|..||.:
Human   320 GDKQPKKQEKNPVL-----VSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQR 379

  Fly   370 HQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQYSLDGYQNMWIVKPANKCRGRGIILM 434
            :.|:|:|...::|     |:..|:.|..::.:::...||..::|.:|:|||||..|.|||||:.|
Human   380 YYQVVHEGAELRH-----LDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCM 439

  Fly   435 DNLKKILGVVNLS--IASKSRYVVQKYIERPLILFQTKFDIRQWFLITNTQPLVVWFYRESYLRF 497
            |:|:::|.:||.:  :....::||||||||||::|.||||:|||||:|:..||.|||||:||:||
Human   440 DHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRF 504

  Fly   498 SSQEYSLSNHHESVHLTNYAIQKKYTNG-KRDKRLPSENMWDCYSFQAYLRQIGKYNMWLERIFP 561
            |:|.:||.|...||||.|.:|||...|. .|...||.:|||....|||:|:::|..|.|...|.|
Human   505 STQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVP 569

  Fly   562 GMRKAIVGCMLASQENMDRRPNTFELFGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCL 626
            ||:.|::..:..||:.:..|..:|||:||||:..|:|.|||||||:||.:..:|:||||:|....
Human   570 GMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQ 634

  Fly   627 EDVVKVVIDRRTDPKAELGNFELAYRQVVPPTPAYMGLNLFVKGKQVLQK--------------- 676
            .|.::|||||..|...:.|.|||.|:|.....|.|:|:.|.|:|..:.:.
Human   635 ADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKKPMAMCHRRMGVRPAVP 699

  Fly   677 --ANHGGGHGHYYYQQQRKERSLATSSVYRQRSAIIHPATS-------ISRIHRAMPTFNATEYM 732
              ...|.|...:::.....:..|.:..|.|.:..::....|       :|...:|:.|.
Human   700 LLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLVGTKALSTTGKALRTL------ 758

  Fly   733 EKYMVEPLSSSRSSLCSQLPQK------SPSAAPALTATPS----------GATSSYILKQAGRS 781
                  |.:....||...|..|      .|..||||.....          ...|...|...|||
Human   759 ------PTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLCPLKSEQFLAPVGRS 817

  Fly   782 ITQLLSATHKRNTGGSLSGEQVQSTALPPKR-------------QRSCG-------------PRL 820
                   ..|.|:....  ::.::.|.|.||             ||..|             |..
Human   818 -------RPKANSRPDC--DKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKLGKPLLRFPTA 873

  Fly   821 SSTNPVESTEKKFKILIKNYSSNGNENMQDARPEVANSATATA 863
            ...:|..:.:|:.|.|..:..:.|...:..|||....| ||.|
Human   874 LVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGS-TARA 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	134/302 (44%)
TTLL3	NP_001021100.3	TTL	356..648	CDD:397308	133/296 (45%)