Protein Alignment TTLL3A and TTLL10

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: XP_047272797.1
• Gene: TTLL10 / 254173
• HGNCID: 26693
• Length: 799
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 151/758 - (19%)
• Similarity: 244/758 - (32%)
• Gaps: 290/758 - (38%)

  Fly     9 PHRSRDQVTDGDRNRDQ--PQKCASATLAKKPVTP-PAAPP---PTPSNRVVAPL-TVPV----- 61
            |.|:|.....|.|.|.|  |:...|.|:....:.| ||:.|   |.|.:..|.|. ..|:
Human   141 PTRTRAGFKRGKRPRIQQRPRARVSGTIPASRLHPAPASQPGPCPAPGHCPVGPAHERPMGSSQE 205

  Fly    62 --IQLTPAQSD---------------------SPVKLA---RPATPKETAISVPDHSNKEN--QP 98
              ::..|:|.|                     .|..|.   |||...:|..:.|..:..|.  ..
Human   206 EGLRCQPSQPDHDADGHCGPDLEGAERASATPGPPGLLNSHRPADSDDTNAAGPSAALLEGLLLG 270

  Fly    99 ARTPPPSKSCP-----LGAP------TNYVARRTWITTERMNELRRKAQEAAKQNKIFTIRGCFN 152
            ...|.|..:.|     :|..      ::|...:.|   :|:::.||..         :|::.|
Human   271 GGKPSPHSTRPGPFFYIGGSNGATIISSYCKSKGW---QRIHDSRRDD---------YTLKWC-- 321

  Fly   153 SVRNALLMRGWVEKLDVHRKVMPAGQMTYEDLTQRLPKRKAGETRRQYVQKCERNIMSRFLEHMP 217
                      .|:..|.:.......|:.|:     ||..|...|:
Human   322 ----------EVKSRDSYGSFREGEQLLYQ-----LPNNKLLTTK-------------------- 351

  Fly   218 VDFLWTNRKEKCDYIDQAKNPGMTINKFHRAPFTSKEGLCSQLRDFHWFFEEGTAEMYFPRCYNV 282
            :..|.|.|.........:|.||....:.      .|:.....|.|..|     |:..|. |...|
Human   352 IGLLSTLRGRARAMSKASKVPGGVQARL------EKDAAAPALEDLPW-----TSPGYL-RPQRV 404

  Fly   283 WSPEELGEFIENFKLTACVAFLRAMLCKYHKQGSDAVFSCSGKIPYSAIDFAYKRLVEYIDSCQH 347
            ...||.  |.|.::|
Human   405 LRMEEF--FPETYRL-------------------------------------------------- 417

  Fly   348 NDIDFEDPPKIWEHDWDAFLFQHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQYSLD 412
             |:         :|:.:||                             .:|.|:.::
Human   418 -DL---------KHEREAF-----------------------------FTLFDETQI-------- 435

  Fly   413 GYQNMWIVKPANKCRGRGIILMDNLKKILGVVNLSIASKSR------------------YVVQKY 459
                 ||.||....:|:||.|:.|.:::     .::.:|:|                  .|||:|
Human   436 -----WICKPTASNQGKGIFLLRNQEEV-----AALQAKTRSMEDDPIHHKTPFRGPQARVVQRY 490

  Fly   460 IERPLILFQTKFDIRQWFLITNTQPLVVWFYRESYLRFSSQEYSLSNHHESVHLTNYAIQKK--- 521
            |:.||::...|||:|.:.||..|.|.:: |:...|.|.:...|...:.....||||..:|||
Human   491 IQNPLLVDGRKFDVRSYLLIACTTPYMI-FFGHGYARLTLSLYDPHSSDLGGHLTNQFMQKKSPL 554

  Fly   522 YTNGKRDKRLPSENMWDCYSFQAYLRQIGKYNMWLER------IFPGMRK----AIVGCMLASQE 576
            |      ..|....:|.......|:..    ..|..|      :|..::|    .:..|.||::.
Human   555 Y------MLLKEHTVWSMEHLNRYISD----TFWKARGLAKDWVFTTLKKRMQQIMAHCFLAAKP 609

  Fly   577 NMDRRPNTFELFGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCLEDVVKVVID------ 635
            .:|.:...|:|.|.||:|.:||..||:|:||:|.|.....|...:.|..:.:.:.:|::
Human   610 KLDCKLGYFDLIGCDFLIDDNFKVWLLEMNSNPALHTNCEVLKEVIPGVVIETLDLVLETFRKSL 674

  Fly   636 -----------RR--------TDPKAELGNFELAYRQVVPPTP 659
                       ||        .||:..||. ..:.|: .||.|
Human   675 RGQKMLPLLSQRRFVLLHNGEADPRPHLGG-SCSLRR-WPPLP 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	75/353 (21%)
TTLL10	XP_047272797.1	PHA03247	<54..283	CDD:223021	33/141 (23%)
		CPSase_L_D2	408..674	CDD:473076	78/385 (20%)