Protein Alignment TTLL3A and TTLL5

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: NP_055887.3
• Gene: TTLL5 / 23093
• HGNCID: 19963
• Length: 1281
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 150/698 - (21%)
• Similarity: 256/698 - (36%)
• Gaps: 159/698 - (22%)

  Fly   356 PKIWEHDWDAFLFQHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQYSLDGYQNMWIV 420
            |:.:|      |.:..:|.....|:||..|.:...::.....|..:.......||.|  :..|||
Human   123 PRSYE------LTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKD--RGPWIV 179

  Fly   421 KPANKCRGRGIILMDNLKKILGVVNLSIASKSRYVVQKYIERPLILFQTKFDIRQWFLITNTQPL 485
            ||....||||:.|::|..:        |:.:...:|.:||..||::...|||:|.:.|:|:..||
Human   180 KPVASSRGRGVYLINNPNQ--------ISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPL 236

  Fly   486 VVWFYRESYLRFSSQEY---SLSNHHESVHLTNYAIQKK---YTNGKRDKRLPSENMWDCYSFQA 544
            |::.|.|...||::..|   :.:..::.:|||||::.||   |.:....:.....|.|...:...
Human   237 VIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLR 301

  Fly   545 YLRQIGKYNMWL-----ERIFPGMRKAIVGCMLASQENMDRRPNTFELFGADFMICENFYPWLIE 604
            ||:|.|:....|     :.|...:..|.:....|.:..:..|.:.|||:|.|.:|.....|||:|
Human   302 YLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLE 366

  Fly   605 INSSPDLGATTSVTARMCPQCLEDVVKVVIDRRTDP----------------------------- 640
            :|.||.|.....:..::....:.|:..||.....||
Human   367 VNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRP 431

  Fly   641 ----KAELGNFELAYRQVVPPTPAYMGLNLFVKGKQVLQKA----NHGGG-------------HG 684
                .||:.|...:.|:..|.......|.|.::..:||::.    :..||             :|
Human   432 LSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYG 496

  Fly   685 HYYYQQQRKERSLATSSVYRQRSAI-------IHPATSISRIHRAMPTFNATEYMEKYMVEPLSS 742
            .|...:......||| .:::.|...       |....|.:::|.|:       |..|.:...:..
Human   497 SYLEHKTSMNYMLAT-RLFQDRMTADGAPELKIESLNSKAKLHAAL-------YERKLLSLEVRK 553

  Fly   743 SR---SSLCSQLPQ----KSPSAAPALTATPSGATSSYILKQAGRSITQLLSATHKRNTGGSLSG 800
            .|   |.|.:..|:    ..|:.....|.|.|.......|.                |.......
Human   554 RRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALD----------------NEDEEQEA 602

  Fly   801 EQVQSTALPPKRQRSCGPRLSSTNPVESTEKKFKILIKNYSSNGNE----NMQDARPEVANSATA 861
            .|.:|.....:.|....|.|::.  ||:|.|:..:.::.:::.|..    ..|:..|:.
Human   603 SQEESAGFLRENQAKYTPSLTAL--VENTPKENSMKVREWNNKGGHCCKLETQELEPKF------ 659

  Fly   862 TAISERKWRSLRNIAATAGGSSNLAARSKGPPLIAPPSLPTRRLTRTKSEIDSTGMHAIGRTFGR 926
                     :|..|....|..|.:.||      ||                .|..:..:.....:
Human   660 ---------NLMQILQDNGNLSKMQAR------IA----------------FSAYLQHVQIRLMK 693

  Fly   927 KSNGPRLPISISVQALHRGEPIVAALKQATSELQLSQAQMMSPRTALA 974
            .|.|.....|.:.:...:.|.:|..||:|::.||.| .:|:.|...||
Human   694 DSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHS-LRMVLPSRRLA 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	79/294 (27%)
TTLL5	NP_055887.3	TTL	117..395	CDD:397308	77/287 (27%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	378..488		16/109 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..614		7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1072..1114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1199..1281