Protein Alignment TTLL3A and Ttll3

DIOPT Version :10

• Sequence 1: NP_609069.1
• Gene: TTLL3A / 33947
• FlyBaseID: FBgn0031854
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: NP_598684.4
• Gene: Ttll3 / 101100
• MGIID: 2141418
• Length: 927
• Species: Mus musculus
• Alignment Length: 929
• Identity: 285/929 - (30%)
• Similarity: 424/929 - (45%)
• Gaps: 177/929 - (19%)

  Fly     9 PHRSRDQVTD-GDRNRDQ---PQKCASATLAKKPVTPPAAPPPTPSNRVVAPLTVPVIQLTPAQS 69
            |..::.:|.. ||..||.   |.:..|:  |::...|.|.....|.         ||..|.|...
Mouse    68 PASAKPEVASCGDSRRDYSSLPARHLSS--ARESSMPGALGTVNPQ---------PVRTLVPPTL 121

  Fly    70 DSPVKLARPATPKETAISVPDHSNKENQPARTPPPSKSC----PLGAPTNYVARRTWITTERMNE 130
            |.|:                        |....||..|.    .|....|::.        |:..
Mouse   122 DEPL------------------------PDALRPPDDSLLLWRGLTKGPNHMG--------RLRN 154

  Fly   131 LRRKAQEAAKQNKIFTIRGCFNSVRNALLMRGWVEKLDVH--RKVMPAGQMTYEDLTQRLPKRKA 193
            .:...:.|.||.|||.|.|.:..:|..|..||||||..||  ...:||.|   :||...:    .
Mouse   155 AKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQ---KDLDSSM----L 212

  Fly   194 GETRRQYVQKCERNIMSR---------FLEHMPVD----------------FLWTNRKEKCDYID 233
            |::.....:..|.|.|.|         |||...:|                .:||.|::..|...
Mouse   213 GDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRF 277

  Fly   234 QAKNPGMTINKFHRA-PFTSKEGLCSQLRDFHWFFEEGTAEMYFPRCYNVWSPEELGEFIENFKL 297
            .:|:  ..||.:.|| .||:|.|||..||:..| |:|..|:.:|||||.:.:.::...|||:|.|
Mouse   278 LSKD--QMINHYARAGSFTTKVGLCLNLRNLPW-FDEADADSFFPRCYRLGAEDDKKAFIEDFWL 339

  Fly   298 TACVAFLRAMLCKYHKQGSDAVFSCSGKIPYSA----------------IDFAYKRLVEYIDSCQ 346
            ||....|:.::....|..|.::.:...:.|...                :|.|.....|::.|..
Mouse   340 TAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIA 404

  Fly   347 HNDIDFEDPPK---IWEHDWDAFLFQHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQ 408
            |.||| :||..   :...||..||.::.|:|:|...:::     ||..|:.|..::.:::...||
Mouse   405 HKDID-KDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRY-----LEVQVQRCEDILQQLQNVVPQ 463

  Fly   409 YSLDGYQNMWIVKPANKCRGRGIILMDNLKKILGVV--NLSIASKSRYVVQKYIERPLILFQTKF 471
            ..::|.:|:|||||..|.|||||:.|:.|.::|.:|  |..:....:::|||||||||::|.|||
Mouse   464 LDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKF 528

  Fly   472 DIRQWFLITNTQPLVVWFYRESYLRFSSQEYSLSNHHESVHLTNYAIQKKY-TNGKRDKRLPSEN 535
            |:|||||:|:..||.|||||:||:|||:|.:||.|...||||.|.:||:.. .:..|...||.:|
Mouse   529 DLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDN 593

  Fly   536 MWDCYSFQAYLRQIGKYNMWLERIFPGMRKAIVGCMLASQENMDRRPNTFELFGADFMICENFYP 600
            ||....|||:|:::.....|...|.|||:.|::..:..||:|:..|..:|||:||||:..|:|.|
Mouse   594 MWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQP 658

  Fly   601 WLIEINSSPDLGATTSVTARMCPQCLEDVVKVVIDRRTDPKAELGNFELAYRQVVPPTPAYMGLN 665
            ||||||:||.:..:|:||||:|.....|.::||||||.|...:.|.|||.|:|.....|.|:|:.
Mouse   659 WLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIR 723

  Fly   666 LFVKGKQVLQKANHGGGH---------GHYYYQQQRKERSLATSSVYRQRS-------AIIH--- 711
            |.|:|..:  |.....||         .|...||...|...:.|..:|..|       ::.|
Mouse   724 LLVEGSTI--KKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEK 786

  Fly   712 --PA--TSIS----------------------RIHRAMPTFNATEYMEKYMVEPLSSSRSSLCSQ 750
              ||  .|:|                      |:||........::.:....:.||::..:|.:
Mouse   787 PEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMT- 850

  Fly   751 LPQ----KSPSAAPALTATPSGATSSYILKQAGRSITQLLSATHKRNTGGSLSGEQVQSTALPPK 811
            ||.    .|....|.|...||       :.:.|:...:|...|.:....|.: ||:.......|:
Mouse   851 LPTAKVLMSFPPHPDLKLAPS-------MLKPGKVGFELCCTTWRVVLSGGI-GEEGHRQRAAPR 907

  Fly   812 RQRSCGPRLSSTNPVESTE 830
            ...:.|..||||.|...||
Mouse   908 PSSAPGKGLSSTEPCSKTE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3A	NP_609069.1	TTL	342..640	CDD:397308	132/303 (44%)
Ttll3	NP_598684.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..113		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..227		8/39 (21%)
		TTL	423..698	CDD:397308	124/279 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..799		14/63 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	897..927		10/30 (33%)