DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL3B and TTLL4B

DIOPT Version :9

Sequence 1:	NP_609068.2	Gene:	TTLL3B / 33946	FlyBaseID:	FBgn0031853	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	173/800 - (21%)
Similarity:	285/800 - (35%)	Gaps:	245/800 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QNTTP-----------AGFTGNRN---RYYNPVSKIQSLIHNLDAELVQLCKQCSVQKPLTSLNN 54
            |::||           ||.|.:.:   ||..|..|.:|              ..|.:|.||.
  Fly   100 QSSTPQHRSSAGGGSAAGATASDSVSARYSPPGQKQRS--------------PPSPRKRLTP--- 147

  Fly    55 STSLGSHFSNFGALGGGSGSK----------TMGGSSS-----------MGSNN----------- 87
                 ...:|.|  |||.|||          |...||:           :.:|:
  Fly   148 -----EKVANLG--GGGGGSKVGAQRIIIRGTPPNSSTPKVAATPSNVPVVANSVLQSEPYKKVQ 205

  Fly    88 ----------FSPDSIGNLLAR------------VRASTP-----LPRTVTSSPTAPEAQKRQMR 125
                      |:..:.||..|.            ::|..|     .|.|.|..|:.|  .|..:.
  Fly   206 MLLKRAREEAFAKHTAGNSAANGNGPKRSAHSPPIQAKVPPSNMSCPSTQTLKPSPP--SKIVVN 268

  Fly   126 NVYRTRVIDAYRNR---RIFTVYGNYHTVRRALMRRGWLEKLPASRHAKLQSMSEDALLEHARR- 186
            :.:.:.::...:..   |:.|..|...:...||.     ..|.||.:|.....|:...  |:.|
  Fly   269 SFHGSSMLSTQQQEEKSRLLTQNGLTKSAATALE-----TSLYASLYANAPQNSQPQF--HSPRI 326

  Fly   187 -GNDYEAVVISKMINHFPAFFIWQGKG-------QRDLCAEVRPFRNRVRRSQFLDFSTKVGLVG 243
             |.|:.|..:...:|        :|.|       :.|.||.:...      :.:.|..::...||
  Fly   327 SGGDHVASYVGVSLN--------KGAGHDNDRKHEDDPCAAIDDI------NYYDDSDSEEEYVG 377

  Fly   244 CAEQERWYREDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVRE---------HQP 299
            ..    ::.|:........:..||    |.::....|..:.|.:.:.:.:..|         |.|
  Fly   378 TP----FFLEEDNTETRQSKHTRL----LPQKTPSKESVRTTDSEASVYFRPEAILSPSLFPHVP 434

  Fly   300 AELISENGTIFSTTLDFALGKVKKMVRHAEHYSLDDARIKPPTP---AEIVENQTFMV--QSTD- 358
            ..|...:.......:..||.:|.|.            ::.|..|   ..:|.|..|.:  .:||
  Fly   435 PYLNFTSHADKGPPMPAALHRVLKW------------KLSPVMPKIVKRVVLNSGFRIIKNTTDW 487

  Fly   359 --------------VLKSNAK-------FKVSEK--------------VMAEYARLAGLYL--DQ 386
                          .::|:.|       |::..|              ...|:..:...|:  |.
  Fly   488 MAVWEKHMKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPDD 552

  Fly   387 IESLRPDYRWDGSR-NLWILKPGYQSRGIGIVIRSSLDDILQWTSNNQNKKYIVQKYIERPLLIY 450
            :||||..:..:.|: ..||:||...:||.||.|      :.:|:...:::..:|||||||||||.
  Fly   553 LESLRQVWPKNASKLTKWIVKPPASARGTGIRI------VNKWSQFPKDRPLVVQKYIERPLLIN 611

  Fly   451 RTKFDIRQYMLLTITDTKVSIWTYRDCYLRFSSQEFT--MDDLRE-SIHLTNNSVQKRYKN-KTN 511
            ..|||:|.|::|| :...:.|:.|:|...||:|.:::  :.:|.| .:||||.|:.|..:| ..|
  Fly   612 DNKFDMRLYVVLT-SINPLRIYMYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFSQNYAKN 675

  Fly   512 RDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMAS---------LDETELLQ 567
            .|....:.:.|:|....:.|...|..    :|......:|||...:.|         ........
  Fly   676 EDFNACQGHKWTLQSLWSCLENRGVN----TKRLWATLRNLVIKGIVSGESGLNRMYRQNVNFRY 736

  Fly   568 NAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLF 632
            |.|||:|.|.:|||:..|.|:|||.:|.|.....:...:                |.|.....|.
  Fly   737 NCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHV----------------KGPLIQAVLN 785

  Fly   633 ELAFEVNYSINKGADGKPLE 652
            ...::|...:|:......||
  Fly   786 TALYQVPPKLNERQQADILE 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:281171	90/357 (25%)
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	87/321 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450539
Domainoid	1	1.000	68	1.000	Domainoid score	I2322
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840