DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL3B and TTLL5

DIOPT Version :9

Sequence 1:	NP_609068.2	Gene:	TTLL3B / 33946	FlyBaseID:	FBgn0031853	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_055887.3	Gene:	TTLL5 / 23093	HGNCID:	19963	Length:	1281	Species:	Homo sapiens

Alignment Length:	365	Identity:	88/365 - (24%)
Similarity:	144/365 - (39%)	Gaps:	89/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 KKMVRHAEHYSLDDARIKPPTPAEIVENQTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQ 386
            |.::|....:......|.|         |||::.                  ||||.....|
Human   136 KNIIRMQHTHGFKAFHILP---------QTFLLP------------------AEYAEFCNSY--- 170

  Fly   387 IESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNNQN-----KKYIVQKYIERP 446
                      ...|..||:||...|||.|:           :..||.|     :..:|.:||..|
Human   171 ----------SKDRGPWIVKPVASSRGRGV-----------YLINNPNQISLEENILVSRYINNP 214

  Fly   447 LLIYRTKFDIRQYMLLTITDTKVSIWTYRDCYLRFSSQEFTM--DDLR-ESIHLTNNSVQKRYKN 508
            |||...|||:|.|:|:|..|..| |:.|.:...||::..:..  .::| :.:||||.||.|:..:
Human   215 LLIDDFKFDVRLYVLVTSYDPLV-IYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGD 278

  Fly   509 KTNRDSRLPK----NNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELL--- 566
            ..:.|.  |:    .|.||:.....||:..|       :.......::..:::.::...||.
Human   279 YVSCDD--PEVEDYGNKWSMSAMLRYLKQEG-------RDTTALMAHVEDLIIKTIISAELAIAT 334

  Fly   567 ---------QNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLP 622
                     .:.|||||.|.::|....|.|:|:|.:|.|:....:..:|...::.|...||..:.
Human   335 ACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVC 399

  Fly   623 KNPT--AATGLFELAFEVN--YSINKGADGKPLELNGKQM 658
            ::|.  |:|......||.:  ....|....:||..:..:|
Human   400 QDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEM 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL3B	NP_609068.2	TTL	325..626	CDD:281171	78/324 (24%)
TTLL5	NP_055887.3	TTL	117..395	CDD:281171	77/319 (24%)
		c-MTBD region. /evidence=ECO:0000269\|PubMed:25959773	378..488		13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1199..1281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840